ID Q8GDZ6_HELMO Unreviewed; 468 AA.
AC Q8GDZ6;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 13-SEP-2023, entry version 88.
DE RecName: Full=CTP synthase (glutamine hydrolyzing) {ECO:0000256|ARBA:ARBA00012291};
DE EC=6.3.4.2 {ECO:0000256|ARBA:ARBA00012291};
DE Flags: Fragment;
OS Heliobacterium mobile (Heliobacillus mobilis).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Heliobacteriaceae;
OC Heliobacterium.
OX NCBI_TaxID=28064 {ECO:0000313|EMBL:AAN87429.1};
RN [1] {ECO:0000313|EMBL:AAN87429.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12446909; DOI=10.1126/science.1075558;
RA Raymond J., Zhaxybayeva O., Gogarten J.P., Gerdes S.Y., Blankenship R.E.;
RT "Whole-genome analysis of photosynthetic prokaryotes.";
RL Science 298:1616-1620(2002).
RN [2] {ECO:0000313|EMBL:AAN87429.1}
RP NUCLEOTIDE SEQUENCE.
RA Liolios K.G., Chu L., Ostrovskaya O., Mendybaeva N., Koukharenko V.,
RA Gerdes S., Kyrpides N., Overbeek R.;
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-
CC glutamate + phosphate; Xref=Rhea:RHEA:26426, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000314};
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway;
CC CTP from UDP: step 2/2. {ECO:0000256|ARBA:ARBA00005171}.
CC -!- SIMILARITY: Belongs to the CTP synthase family.
CC {ECO:0000256|ARBA:ARBA00007533}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00605}.
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DR EMBL; AY142825; AAN87429.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8GDZ6; -.
DR MEROPS; C26.964; -.
DR UniPathway; UPA00159; UER00277.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003883; F:CTP synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd03113; CTPS_N; 1.
DR CDD; cd01746; GATase1_CTP_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR004468; CTP_synthase.
DR InterPro; IPR017456; CTP_synthase_N.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR033828; GATase1_CTP_Synthase.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00337; PyrG; 1.
DR PANTHER; PTHR11550; CTP SYNTHASE; 1.
DR PANTHER; PTHR11550:SF0; CTP SYNTHASE-RELATED; 1.
DR Pfam; PF06418; CTP_synth_N; 1.
DR Pfam; PF00117; GATase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AAN87429.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975}.
FT DOMAIN 2..240
FT /note="CTP synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06418"
FT DOMAIN 275..467
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT NON_TER 468
FT /evidence="ECO:0000313|EMBL:AAN87429.1"
SQ SEQUENCE 468 AA; 52318 MW; 51E548CCB7D98AA5 CRC64;
MSSRGLKVCI QKFDPYINID PGTMSPYQHG EVFVTDDGAE TDLDLGHYER FVDVNLSKAS
NVTTGKIYWS VISKERKGEY LGGTVQVIPH ITNEIKERVL RVARESSPDV VITEIGGTVG
DIESLPFLEA IRQMKSDVGR DRVIYIHVTL MPFISAAGEL KTKPTQHSVK ELRSIGIQPD
IIVCRTEKAF PQELEEKIAL FCDIDPAAVI QMVDAETIYE VPLLLKKEEL DDIVIEKLKL
TCGEPDLKDW EALVHKIKNP KQQVTIGLVG KYVALPDAYM SVAESLRHAG IHHNASVKIK
WIYSADLEGA PPEDFLSDVD GILVPGGFGD RGIEGKISAL RYARENKIPL LGICLGMQLA
VVEYGRNVLG WEDANSSEFS ETTTHPVIDL LPEQKDVEEK GGTMRLGIWA CRVNKGTKTW
DAYQDEVIYE RHRHRYEFNN NYREAIEKAG MIISGTSPDG RLVEVVEL
//
