ID Q8I1S9_PLAF7 Unreviewed; 875 AA.
AC Q8I1S9;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=RING zinc finger protein, putative {ECO:0000313|EMBL:CAD49195.1};
GN ORFNames=PF3D7_0415800 {ECO:0000313|EMBL:CAD49195.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD49195.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|EMBL:CAD49195.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL844503; CAD49195.1; -; Genomic_DNA.
DR RefSeq; XP_001351466.1; XM_001351430.1.
DR AlphaFoldDB; Q8I1S9; -.
DR SMR; Q8I1S9; -.
DR IntAct; Q8I1S9; 1.
DR STRING; 36329.Q8I1S9; -.
DR PaxDb; 5833-PFD0765w; -.
DR EnsemblProtists; CAD49195; CAD49195; PF3D7_0415800.
DR GeneID; 812545; -.
DR KEGG; pfa:PF3D7_0415800; -.
DR VEuPathDB; PlasmoDB:PF3D7_0415800; -.
DR HOGENOM; CLU_379715_0_0_1; -.
DR InParanoid; Q8I1S9; -.
DR OMA; YDNFRCP; -.
DR OrthoDB; 230204at2759; -.
DR PhylomeDB; Q8I1S9; -.
DR Reactome; R-PFA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000001450; Chromosome 4.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; ISS:GeneDB.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23327; RING FINGER PROTEIN 127; 1.
DR PANTHER; PTHR23327:SF50; TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 79..117
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 560..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 106504 MW; 4859E9F16DDBABA3 CRC64;
MAGYFFGNVQ NNLNRARHSL TNTLSDMRLD ESYLKSIRMN IKKRFDKLMN KIIPFETIDE
NKRFVVIIEK KKNYENFRCP ICMLILFKPV KTKCGHIFCR ECIEKVLLKF DYCPLCRNFI
KDKKLENVEN STLGSEYENI KIRCYKCKEI TNIKNYEKHI INHIMNIHKS FDNIKNYSTS
EEGDNYNFLS IQKKKKNSNY IYSISNNNYI HNIYHHINPY NFDSYFNKKF QIIYMKEFFN
LLKEHNINTH IDNFYLLYAQ NVLYDFKHIN VEVQDIMCDV FLIIKIRKKR KNYHQNNLNL
LYLDNSKYKS EQINNIITSK DDINMNVNMN IHTNIHMNIH TNIHTNIHTN IHTNIHANDG
FISSEGEKKK DIKQNNFITN DLKKQKSIIF SSYKKKLYTN DTFEMYQKKL LIHNKKTPNK
YIYILFEYNT KNIFFTLLQN IPVFKNMNII KLVKYKNKKM NSIGHTTNIS EQLIRLFSIL
NEKRILRTYH KYFYNSIHLF HELIYSLLFS KHQKEKNENI ENIDVAYMQD IYEMERSYQM
EEKQLNDVNY HIYQKCDHYE NNQNGQNEQN DQNEEPYQHY NDQNEEPYQH YNDQNEQPYQ
HYNDHNEEPS EHYNDNYYNF VEKNEHNFKN IFLKDYELMF ILFYLKYEYR LPLKCEYLYL
YSENFIAKIL RDQEREQDIF ISNVYSYHNL DILQNKINGE NILPLSNNEF VKNDKGIIII
LQVQRGKLKN EYKSDINIID NKNNCNDILN NNQYINQTEE NINNSEYTNK KDFYKKYVQK
KSNKTNTHTK NINQYYDIHN VCYLIISYSS KGFQWYLNNS LNFLNKKQIE YKSQEVFFLI
DKLILFFFNI RNKKYSSVFW NSTHLFQCML NFCCE
//
