ID Q8I569_PLAF7 Unreviewed; 1662 AA.
AC Q8I569;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 144.
DE SubName: Full=CCR4-NOT transcription complex subunit 4, putative {ECO:0000313|EMBL:CZT99512.1};
GN ORFNames=PF3D7_1235300 {ECO:0000313|EMBL:CZT99512.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT99512.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT99512.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
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DR EMBL; LN999947; CZT99512.1; -; Genomic_DNA.
DR RefSeq; XP_001350747.1; XM_001350711.1.
DR AlphaFoldDB; Q8I569; -.
DR SMR; Q8I569; -.
DR IntAct; Q8I569; 12.
DR STRING; 36329.Q8I569; -.
DR PaxDb; 5833-PFL1705w; -.
DR EnsemblProtists; CZT99512; CZT99512; PF3D7_1235300.
DR GeneID; 811393; -.
DR KEGG; pfa:PF3D7_1235300; -.
DR VEuPathDB; PlasmoDB:PF3D7_1235300; -.
DR HOGENOM; CLU_242124_0_0_1; -.
DR InParanoid; Q8I569; -.
DR OMA; NIYNIHE; -.
DR OrthoDB; 1748at2759; -.
DR Proteomes; UP000001450; Chromosome 12.
DR GO; GO:0030014; C:CCR4-NOT complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd16618; mRING-HC-C4C4_CNOT4; 1.
DR CDD; cd12438; RRM_CNOT4; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034261; CNOT4_RRM.
DR InterPro; IPR039780; Mot2.
DR InterPro; IPR039515; NOT4_mRING-HC-C4C4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12603; CCR4-NOT TRANSCRIPTION COMPLEX RELATED; 1.
DR PANTHER; PTHR12603:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF14570; zf-RING_4; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 125..168
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 341..426
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 24..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1481..1539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..620
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1253
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1277
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1331
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1662 AA; 194674 MW; D96A5716F10A282E CRC64;
MRRGLGNEKR FLRRSFNRSY YYKKNEKEKI EEMNSRKNNN YEKEEEEDDE EDIDGVDEDI
KEKCSKAVCD MNSSDIEERN EKKKKNEKFI VKEKKELSVN DESFLIKNME QNNNDKGQDK
NNVICPLCVE VLDETDRNFF PCDCGYQICL WCLYYIRDHM NNTCPACRRS YEEKNFIYNK
ETHEKLIKKQ KSNKNKSDNN NNNNNNNNNI NRGDNNYMNN INLTNMNEMN NINDMNNINN
NNNDDNNNNN DNNNNDNNND NDNNNDNNNN NNNNNNNNNN NNNNNNNNYY YYISNNYNNN
YSSSGSLLYR SDTYKHPNIY NIHEYDNLLE IIKSIRVVQR NLVFVIGITA TYAKKTVLKK
NEHFGKYGKI LNIIINKSQA YNPQYNGPSF SAYITYSNEK EAINAIYFID GMTLDNKILK
ASFGTTKYCS SFLKNASCGN EECFYLHELG NVIDSFSKDD IHGPKHIYHD LLYLYFKKLP
DKKNDGTYDS LSNSITIKNF KLNEEDVSSL VKIEKTETKK KLENNIEDTN VNDDIKKNNN
INYTEFKYFN EWKNKNLNLE KIKQDQNKNA PPQNNKQSKW IMEDKILQIK KSATHDNIPI
QSNDQENYDI DDDIHDNDIN DMDDVDDKKS NNNNKIKAKK KKKSKSEDVL PLDMLKNNSY
IATNKNNIPT NDKKGKNYLN SVQNTSTSLI FNSYSDDKDH ISKNKNNNTS KNNNNNNNNN
NVMNDTDYLN ELSENYPSIN EALLDKDKKK KAKKKAEKNK AEKNKAEKNK AEKNKAEKNK
AEKNKAEKNK AEINKTDTNK ENTNNEDKNN EDKNNEDKNN EDKNNEEDRN KIITKNESEE
QKKENDSTDT KKNKKKNQNN QLIENKKKEQ DNINKNNITN NKQESNNINE KSTDDSKKFT
SLISNYFSEL LDKKKKKDTS KNETQEKNEE INKENVIDKK KNKNTQPQHV IIFNNNNDNY
NNNNNNNNNS NIIIGFREGQ VELARRKEFI FTDDGKIKKI VEEKDKLEGK SKEDKKGDQQ
SDVHQIIDKK QGGIENQSLE ESKRKAKNIQ QKDNTKNAEL LKCDEKKTEG NLSNTLTHYV
TNQQDNFDQD IENNIHNQNE ENNLNKNTSK GKKKIENNNK VVDTKILNIE DIIKMKSINN
NDNIKLPEEI KEYIKKMKSG GIKENVEYDI YHKFINNYFN VKEYVDGIIV VEEKEVKAMK
GNDNNVKDQK KGKHEEDNKK KVLISKTEEG DTSKRKQKNM SDKKNKKEKR KKKKDKKNDN
DNEEENDNEE DQEEDEKQDI INKDGILQKE NKKIKNKNKT KKKNDQEEKE EEDEDDEDEE
DDDEEEEEEI QKDNVTLIKK KKKKKEKKNI SNKKNVMYHK EMEGYIMDTI MGIILNELKG
KNNVKQININ KNNYDDEKNV LLKDVEIFIK NLCVAKCKSI ENNKNKENIL YIIEEGNDEN
NTSKKKEAKK KAKRNDYIIY SNDEHTFLKS HKGIMQYILK NGNTSSNKNN KIKNVDDKNN
NVDDKNNNVD DKNNNVDDKN KNVGDKNKNG DDKNKNVGDS NKAKIKISEY LNDKNTFDFF
KDLIISNNQD TIHTPDHIIF DKIFNEQINF VQQLCETDFK INSRNVISTN KKTDRHLYQS
NQNVHNKLKK NTQGGGNISN IWVNFDNTVQ NKELNEKLNL SA
//
