ID   Q8IAH1_9MUSC            Unreviewed;       355 AA.
AC   Q8IAH1;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   RecName: Full=alpha-amylase {ECO:0000256|ARBA:ARBA00012595};
DE            EC=3.2.1.1 {ECO:0000256|ARBA:ARBA00012595};
DE   Flags: Fragment;
GN   Name=Amy {ECO:0000313|FlyBase:FBgn0044271};
OS   Drosophila lacteicornis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=67531 {ECO:0000313|EMBL:BAB39183.1};
RN   [1] {ECO:0000313|EMBL:BAB39183.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=14028-0571.0 {ECO:0000313|EMBL:BAB39183.1};
RA   Zhang Z., Inomata N., Cariou M., Yamazaki T.;
RT   "Molecular Phylogeny and Evolution of the Amylase Multigenes in the
RT   Drosophila montium Species Subgroupum.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in
CC         polysaccharides containing three or more (1->4)-alpha-linked D-
CC         glucose units.; EC=3.2.1.1; Evidence={ECO:0000256|ARBA:ARBA00000548};
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- COFACTOR:
CC       Name=chloride; Xref=ChEBI:CHEBI:17996;
CC         Evidence={ECO:0000256|ARBA:ARBA00001923};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC       {ECO:0000256|ARBA:ARBA00008061, ECO:0000256|RuleBase:RU003615}.
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DR   EMBL; AB048769; BAB39183.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8IAH1; -.
DR   CAZy; GH13; Glycoside Hydrolase Family 13.
DR   FlyBase; FBgn0044271; Dlar\Amy.
DR   GO; GO:0004556; F:alpha-amylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0043169; F:cation binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd11317; AmyAc_bac_euk_AmyA; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR006046; Alpha_amylase.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR43447; ALPHA-AMYLASE; 1.
DR   PANTHER; PTHR43447:SF49; ALPHA-AMYLASE; 1.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   PRINTS; PR00110; ALPHAAMYLASE.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|ARBA:ARBA00023214};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1..345
FT                   /note="Glycosyl hydrolase family 13 catalytic"
FT                   /evidence="ECO:0000259|SMART:SM00642"
FT   REGION          298..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAB39183.1"
FT   NON_TER         355
FT                   /evidence="ECO:0000313|EMBL:BAB39183.1"
SQ   SEQUENCE   355 AA;  38909 MW;  84003B9FCB9E77F5 CRC64;
     PNGFAGVQVS PVNENAVKDS RPWWERYQPI SYKLVTRSGN EEQFASMVRR CNAVGVRIYV
     DVLLNHMAAD GGTYGTGGST ANPSSKSYPG VPYSSLDFNP TCAISNYNDA NQVRNCELVG
     LRDLNQGGTY VRDMIVSFLD HLIDLGVAGF RVDAAKHMWP ADLGVIYGRL KNLNTDHGFS
     SGAKAYIFQE VIDMGGEAIS KDEYTGLGAI TEFRHSDSIG KAFRGKDQLR YMSNWGTAWG
     FAASDRSLIF VDNHDNQRGH GAGGADVLTY KVPKQYKMAS AFMLAHPFGT PRVMSSFSFT
     NTDQGPPTTD GQNIASPTFN SDNSCSGGWV CEHRWRQIYN MVAFRNAVGS DALQN
//