ID Q8IBT2_PLAF7 Unreviewed; 327 AA.
AC Q8IBT2;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 134.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000256|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000256|HAMAP-Rule:MF_03008};
GN ORFNames=PF3D7_0716800 {ECO:0000313|EMBL:CAD50916.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD50916.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the WD repeat STRAP family.
CC {ECO:0000256|ARBA:ARBA00038394}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000256|HAMAP-
CC Rule:MF_03008}.
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DR EMBL; AL844506; CAD50916.1; -; Genomic_DNA.
DR RefSeq; XP_001349071.1; XM_001349035.1.
DR AlphaFoldDB; Q8IBT2; -.
DR SMR; Q8IBT2; -.
DR IntAct; Q8IBT2; 4.
DR STRING; 36329.Q8IBT2; -.
DR SwissPalm; Q8IBT2; -.
DR PaxDb; 5833-MAL7P1-81; -.
DR EnsemblProtists; CAD50916; CAD50916; PF3D7_0716800.
DR GeneID; 2655045; -.
DR KEGG; pfa:PF3D7_0716800; -.
DR VEuPathDB; PlasmoDB:PF3D7_0716800; -.
DR HOGENOM; CLU_043845_0_1_1; -.
DR InParanoid; Q8IBT2; -.
DR OMA; VWFSHNG; -.
DR OrthoDB; 5474889at2759; -.
DR PhylomeDB; Q8IBT2; -.
DR Reactome; R-PFA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-PFA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-PFA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-PFA-72702; Ribosomal scanning and start codon recognition.
DR Proteomes; UP000001450; Chromosome 7.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:GeneDB.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:GeneDB.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:GeneDB.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19877; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I; 1.
DR PANTHER; PTHR19877:SF1; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_03008};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_03008}; Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 6..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 133..193
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 180..212
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 284..325
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 327 AA; 37284 MW; D4CE3E51312C6C38 CRC64;
MKRKYLSGHN RPLTHVNTNY DGDLLFTTGR DKKFILWRVS DGTQIGLYEC SGAVYNSDVT
YDSKRIVCSS AANKVYLFDV YTGEPLKIIE ENGPVRFVEF NKDPLNQDKI VVAHDRLKSD
HKRSIKLYDL KSDNLIWKQD HESRCIQVRW CFFDKLILSA HENGEIVVWN AEDGHLIRKF
QAHSKEVTNL SFDKDRMLML SSSLDGTAKL RDGVNFEIIN EYKTDRPLNT CDISPLFKNE
NNPKNHIILA GGQAAEHVTT TASGEGKFQT LLYDIIHSNE LGSIKGHFGP VHSIKFLPHG
DGFVSGGEDG FARIYHFDND YFIGKYD
//
