ID Q8IJ45_PLAF7 Unreviewed; 762 AA.
AC Q8IJ45;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=Duffy binding-like merozoite surface protein 2 {ECO:0000313|EMBL:CZT98618.1};
GN ORFNames=PF3D7_1036300 {ECO:0000313|EMBL:CZT98618.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT98618.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT98618.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0007829|PDB:3VUU, ECO:0007829|PDB:3VUV}
RP X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 161-460 IN COMPLEX WITH ZINC, AND
RP DISULFIDE BONDS.
RX PubMed=22843685; DOI=10.1074/jbc.M112.350504;
RA Hodder A.N., Czabotar P.E., Uboldi A.D., Clarke O.B., Lin C.S., Healer J.,
RA Smith B.J., Cowman A.F.;
RT "Insights into Duffy binding-like domains through the crystal structure and
RT function of the merozoite surface protein MSPDBL2 from Plasmodium
RT falciparum.";
RL J. Biol. Chem. 287:32922-32939(2012).
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DR EMBL; LN999944; CZT98618.1; -; Genomic_DNA.
DR RefSeq; XP_001347639.1; XM_001347603.1.
DR PDB; 3VUU; X-ray; 2.09 A; A=160-460.
DR PDB; 3VUV; X-ray; 2.11 A; A=125-460.
DR PDBsum; 3VUU; -.
DR PDBsum; 3VUV; -.
DR AlphaFoldDB; Q8IJ45; -.
DR SMR; Q8IJ45; -.
DR STRING; 36329.Q8IJ45; -.
DR PaxDb; 5833-PF10_0355; -.
DR EnsemblProtists; CZT98618; CZT98618; PF3D7_1036300.
DR GeneID; 810512; -.
DR KEGG; pfa:PF3D7_1036300; -.
DR VEuPathDB; PlasmoDB:PF3D7_1036300; -.
DR HOGENOM; CLU_366196_0_0_1; -.
DR InParanoid; Q8IJ45; -.
DR OMA; IMLANEN; -.
DR OrthoDB; 5573635at2759; -.
DR PhylomeDB; Q8IJ45; -.
DR Proteomes; UP000001450; Chromosome 10.
DR GO; GO:0009986; C:cell surface; IDA:GeneDB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046812; F:host cell surface binding; IDA:GeneDB.
DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.830; -; 1.
DR Gene3D; 1.20.1310.20; Duffy-antigen binding domain; 1.
DR InterPro; IPR042202; Duffy-ag-bd_sf.
DR InterPro; IPR008602; Duffy-antigen-binding.
DR InterPro; IPR010784; Merozoite_SPAM.
DR Pfam; PF05424; Duffy_binding; 1.
DR Pfam; PF07133; Merozoite_SPAM; 1.
DR SUPFAM; SSF140924; Duffy binding domain-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3VUU, ECO:0007829|PDB:3VUV};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:CZT98618.1};
KW Metal-binding {ECO:0007829|PDB:3VUV};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}; Zinc {ECO:0007829|PDB:3VUV}.
FT TRANSMEM 7..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..348
FT /note="Duffy-antigen binding"
FT /evidence="ECO:0000259|Pfam:PF05424"
FT REGION 469..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..669
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 249
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:3VUV"
FT BINDING 254
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:3VUV"
FT BINDING 257
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:3VUV"
FT BINDING 278
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0007829|PDB:3VUV"
FT BINDING 316
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0007829|PDB:3VUV"
FT BINDING 319
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0007829|PDB:3VUV"
FT BINDING 356
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:3VUV"
FT DISULFID 162..334
FT /evidence="ECO:0007829|PDB:3VUU, ECO:0007829|PDB:3VUV"
FT DISULFID 168..323
FT /evidence="ECO:0007829|PDB:3VUU, ECO:0007829|PDB:3VUV"
FT DISULFID 177..212
FT /evidence="ECO:0007829|PDB:3VUV"
FT DISULFID 358..446
FT /evidence="ECO:0007829|PDB:3VUU, ECO:0007829|PDB:3VUV"
FT DISULFID 372..393
FT /evidence="ECO:0007829|PDB:3VUU, ECO:0007829|PDB:3VUV"
FT DISULFID 441..444
FT /evidence="ECO:0007829|PDB:3VUU, ECO:0007829|PDB:3VUV"
SQ SEQUENCE 762 AA; 87573 MW; 64AF06E1A12257B8 CRC64;
MIYILSIVFY IFFLHIDIYV NIYSTCFVVN EGNPNLRNNI INDDELKGKA YNNTIDANNQ
NIEYNKNLKH NVNSSHISKF SDIMDQEDKG DNENSHDIKF EEKKNINKSL DAESNYGINE
ISITGNDSNS DNSNQNIFPD GSELAGGIPR SIYTINLGFN KCPTEEICKD FSNLPQCRKN
VHERNNWLGS SVKNFSSDNK GVLVPPRRQS LCLRITLQDF RTKKKKEGDF EKFIYSYASS
EARKLRTIHN NNLEKAHQAI RYSFADIGNI IRGDDMMDTP TSKETITYLE KVLKIYNENN
DKPKDAKKWW TENRHHVWEA MMCGYQSAQK DNQCTGYGNI DDIPQFLRWF REWGTYVCEE
SEKNMNTLKA VCFPKQPRTE ANPALTVHEN EMCSSTLKKY EEWYNKRKTE WTEQSIKYNN
DKINYTDIKT LSPSEYLIEK CPECKCTKKN LQDVFELTFD GKALLEKLKK EESPVSNSVN
ALPEPGQITL PDPSLKQTTQ QENQPVVETP VTTAVINEHQ GQTEPNKGDN NNERENHESN
VGSIQEVNQG SVSEESHSKT IDPSKIDDRL ELSSGSSSLE QHSKEDVKKG CALELVPLSL
SDIEQIANES EDVLEEIEEE INTDGEIEYI TEEEIKEDIE EETEEDIEEE TEEETEEETE
EEADEETVKE IEDKPEQEIK NKSLEEKQID KNTDTSEKKG FNNSEKDEKA RNLISKNYKN
YNELDKNVHT LVNSIISLLE EGNGSDSTLN SLSKDITNLF KN
//
