ID Q8IL88_PLAF7 Unreviewed; 424 AA.
AC Q8IL88;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 147.
DE SubName: Full=HSP40, subfamily A {ECO:0000313|EMBL:CZU00077.1};
GN ORFNames=PF3D7_1437900 {ECO:0000313|EMBL:CZU00077.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZU00077.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZU00077.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
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DR EMBL; LN999946; CZU00077.1; -; Genomic_DNA.
DR RefSeq; XP_001348533.1; XM_001348497.1.
DR AlphaFoldDB; Q8IL88; -.
DR SASBDB; Q8IL88; -.
DR SMR; Q8IL88; -.
DR IntAct; Q8IL88; 3.
DR STRING; 36329.Q8IL88; -.
DR ChEMBL; CHEMBL1795092; -.
DR DrugBank; DB11638; Artenimol.
DR SwissPalm; Q8IL88; -.
DR PaxDb; 5833-PF14_0359; -.
DR EnsemblProtists; CZU00077; CZU00077; PF3D7_1437900.
DR GeneID; 811941; -.
DR KEGG; pfa:PF3D7_1437900; -.
DR VEuPathDB; PlasmoDB:PF3D7_1437900; -.
DR HOGENOM; CLU_017633_10_2_1; -.
DR InParanoid; Q8IL88; -.
DR OMA; SSKYVYH; -.
DR OrthoDB; 2785358at2759; -.
DR PhylomeDB; Q8IL88; -.
DR Reactome; R-PFA-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR Proteomes; UP000001450; Chromosome 14.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030544; F:Hsp70 protein binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051087; F:protein-folding chaperone binding; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd10747; DnaJ_C; 1.
DR CDD; cd10719; DnaJ_zf; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 2.10.230.10; Heat shock protein DnaJ, cysteine-rich domain; 1.
DR Gene3D; 2.60.260.20; Urease metallochaperone UreE, N-terminal domain; 2.
DR InterPro; IPR002939; DnaJ_C.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR044713; DNJA1/2-like.
DR InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR InterPro; IPR001305; HSP_DnaJ_Cys-rich_dom.
DR InterPro; IPR036410; HSP_DnaJ_Cys-rich_dom_sf.
DR InterPro; IPR036869; J_dom_sf.
DR PANTHER; PTHR43888:SF10; DNAJ-LIKE-2, ISOFORM A; 1.
DR PANTHER; PTHR43888; DNAJ-LIKE-2, ISOFORM A-RELATED; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF01556; DnaJ_C; 1.
DR Pfam; PF00684; DnaJ_CXXCXGXG; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF57938; DnaJ/Hsp40 cysteine-rich domain; 1.
DR SUPFAM; SSF49493; HSP40/DnaJ peptide-binding domain; 2.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51188; ZF_CR; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00546}; Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00546};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00546}.
FT DOMAIN 27..88
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT DOMAIN 136..219
FT /note="CR-type"
FT /evidence="ECO:0000259|PROSITE:PS51188"
FT ZN_FING 136..219
FT /note="CR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00546"
FT REGION 398..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 424 AA; 48469 MW; 82AC28664A6DF57F CRC64;
MFFSSGFPFD SMGGQQARRK REVNNNKFYE VLNLKKNCTT DEVKKAYRKL AIIHHPDKGG
DPEKFKEISR AYEVLSDEEK RKLYDEYGEE GLENGEQPAD ATDLFDFILN AGKGKKKRGE
DIVSEVKVTL EQLYNGATKK LAISKDIICT NCEGHGGPKD AKVDCKQCNG RGTKTYMRYH
SSVLHQTEVT CNTCRGKGKI FNEKDKCANC KGMCVLKTRK IIEVYIPKGA PNKHKIVFNG
EADEKPNVIT GNLVVILNEK QHPVFRREGI DLFMNYKISL YESLTGFVAE VTHLDERKIL
VNCTNSGFIR HGDIREVLDE GMPTYKDPFK KGNLYITFEV EYPMDLIITN ENKEVLKILK
KQNEVEKKYD LENSELEVVS CSPVDKEYIK VRVTKQQQQQ QQEAYDDEDH QPEMEGGRVA
CAQQ
//
