ID Q8JFD4_TAKRU Unreviewed; 463 AA.
AC Q8JFD4; H2S749;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=Runt-related transcription factor {ECO:0000256|PIRNR:PIRNR009374};
GN Name=runx2 {ECO:0000313|EMBL:AAM74030.1,
GN ECO:0000313|Ensembl:ENSTRUP00000008221.2};
GN Synonyms=frRUNX2 {ECO:0000313|EMBL:AAU14190.1}, frRunx2
GN {ECO:0000313|EMBL:BAF36005.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|EMBL:AAM44087.1};
RN [1] {ECO:0000313|EMBL:AAM74030.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12095689; DOI=10.1016/S0378-1119(02)00592-9;
RA Eggers J.H., Stock M., Fliegauf M., Vonderstrass B., Otto F.;
RT "Genomic characterization of the RUNX2 gene of Fugu rubripes.";
RL Gene 291:159-167(2002).
RN [2] {ECO:0000313|EMBL:AAM44087.1}
RP NUCLEOTIDE SEQUENCE.
RA Laize V., Cancela M.L.;
RT "Identification of Takifugu rubripes transcription factor Cbfa1 by
RT comparative genomics.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAU14190.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15527507; DOI=10.1186/1471-2148-4-43;
RA Glusman G., Kaur A., Hood L., Rowen L.;
RT "An enigmatic fourth runt domain gene in the fugu genome: ancestral gene
RT loss versus accelerated evolution.";
RL BMC Evol. Biol. 4:43-43(2004).
RN [4] {ECO:0000313|EMBL:BAF36005.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17604919; DOI=10.1016/j.gene.2007.05.014;
RA Ng C., Osato M., Tay B., Venkatesh B., Ito Y.;
RT "cDNA cloning of Runx family genes from the pufferfish (Fugu rubripes).";
RL Gene 399:162-173(2007).
RN [5] {ECO:0000313|Ensembl:ENSTRUP00000008221.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [6] {ECO:0000313|Ensembl:ENSTRUP00000008221.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR009374}.
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DR EMBL; AY099503; AAM44087.1; -; mRNA.
DR EMBL; AH011684; AAM74030.1; -; Genomic_DNA.
DR EMBL; AF477383; AAM74030.1; JOINED; Genomic_DNA.
DR EMBL; AY739093; AAU14190.1; -; Genomic_DNA.
DR EMBL; AB280006; BAF36005.1; -; mRNA.
DR RefSeq; NP_001027815.1; NM_001032643.2.
DR STRING; 31033.ENSTRUP00000008221; -.
DR Ensembl; ENSTRUT00000008269.3; ENSTRUP00000008221.2; ENSTRUG00000003501.3.
DR GeneID; 445986; -.
DR KEGG; tru:445986; -.
DR CTD; 405788; -.
DR eggNOG; KOG3982; Eukaryota.
DR GeneTree; ENSGT00940000166083; -.
DR OMA; XTTERPN; -.
DR OrthoDB; 2881451at2759; -.
DR TreeFam; TF321496; -.
DR Proteomes; UP000005226; Chromosome 16.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt.
DR GO; GO:0051094; P:positive regulation of developmental process; IEA:UniProt.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 2.60.40.720; -; 1.
DR InterPro; IPR000040; AML1_Runt.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR InterPro; IPR013524; Runt_dom.
DR InterPro; IPR027384; Runx_central_dom_sf.
DR InterPro; IPR013711; RunxI_C_dom.
DR InterPro; IPR016554; TF_Runt-rel_RUNX.
DR PANTHER; PTHR11950; RUNT RELATED; 1.
DR PANTHER; PTHR11950:SF39; RUNT-RELATED TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00853; Runt; 1.
DR Pfam; PF08504; RunxI; 1.
DR PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 1.
DR PRINTS; PR00967; ONCOGENEAML1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS51062; RUNT; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR009374};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR009374};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR009374}.
FT DOMAIN 67..195
FT /note="Runt"
FT /evidence="ECO:0000259|PROSITE:PS51062"
FT REGION 27..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 129
FT /ligand="chloride"
FT /ligand_id="ChEBI:CHEBI:17996"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
FT BINDING 133
FT /ligand="chloride"
FT /ligand_id="ChEBI:CHEBI:17996"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
FT BINDING 156
FT /ligand="chloride"
FT /ligand_id="ChEBI:CHEBI:17996"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
FT BINDING 187
FT /ligand="chloride"
FT /ligand_id="ChEBI:CHEBI:17996"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
SQ SEQUENCE 463 AA; 50335 MW; 7415289DB82E77C2 CRC64;
MASNSLFSTV TPCQQNFFWD PSATRRFSPP SSSLQPVPGK MNDVSSPTGQ PDAAAAVPRL
RPHENRSMAE IIADHPAELV RTDSPNFLCS VLPSHWRCNK TLPVAFKVVA LGDIPDGTVV
TVMAGNDENY SAELRNASGV MKNQVARFND LRFVGRSGRG KSFTLTITVF TNPPQVATYH
RAIKVTVDGP REPRRHRQKL EDPPKAGLFS DRLSELERMR VRVAVPTQGP RPTLNTVANS
FNPQGQTQIT DPRQSQSSPP WSYDQTYQSY LSPMASPSVH STTPLSSSRG TGLPAISDVP
RRLPGSSDLS PFPGQFDRQF PGLPSITESR FSSPRMHYPA TFTYTPPVTT GMSLGSAHYH
TYLPPPYPGS TQSQSTPFQT SSTPYLYYGA SSGSYQFSMV PGGDRSPSRM IPPCTSASTG
TTLVNPNLPS QTEGAVDGDG SHSNSPTILN PGGRMDEAVW RPY
//
