ID Q8MI04_SHEEP Unreviewed; 367 AA.
AC Q8MI04; A0A6P9FN98;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Somatostatin receptor subtype 5 {ECO:0000313|EMBL:CAD29615.1};
GN Name=sst5 {ECO:0000313|EMBL:CAD29615.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|EMBL:CAD29615.1};
RN [1] {ECO:0000313|EMBL:CAD29615.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pituitary gland {ECO:0000313|EMBL:CAD29615.1};
RA Debus N.;
RT "Regulation of GH secretion in sheep: Role of somatostatin and its
RT receptors.";
RL Thesis (1999), Department of Intercellular communications in Endocrinology,
RL University of Aix-Marseilles II, Marseilles, France.
RN [2] {ECO:0000313|EMBL:CAD29615.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pituitary gland {ECO:0000313|EMBL:CAD29615.1};
RX PubMed=12206873; DOI=10.1016/S0739-7240(02)00177-7;
RA Debus N., Dutour A., Boudouresque F., Vuaroqueaux V., Oliver C., Ouafik L.;
RT "Molecular cloning and tissue distribution of the ovine somatostatin
RT receptor subtype 5: osst5.";
RL Domest. Anim. Endocrinol. 23:397-410(2002).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AJ441116; CAD29615.1; -; mRNA.
DR RefSeq; NP_001009265.1; NM_001009265.1.
DR AlphaFoldDB; Q8MI04; -.
DR SMR; Q8MI04; -.
DR GeneID; 443210; -.
DR KEGG; oas:443210; -.
DR CTD; 6755; -.
DR OrthoDB; 5393360at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004994; F:somatostatin receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000586; Somatstn_rcpt.
DR InterPro; IPR001184; Somatstn_rcpt_5.
DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1.
DR PANTHER; PTHR24229:SF20; SOMATOSTATIN RECEPTOR TYPE 5; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00246; SOMATOSTATNR.
DR PRINTS; PR00591; SOMATOSTTN5R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 57..305
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 367 AA; 40269 MW; FA9CAB7AA8BBD764 CRC64;
MEPLFLASPL TVWNTSSAVP SGRPMRMGRW RAGALPGARA VVVPVLYLLV CAVGLGGNAL
VIYVVLRHAK MKTVTNIYIL NLAVADVLLM LGLPFVATQN AISYWPFGPV LCRLVMTLDG
INQFTSIFCL TVMSVDRYLA VVHPIRSARW RRPRVAKLAS AAVWAFSLVM SLPLVVFADI
QEGWNTCNLT WPEPVGLWGA VFIIYTSVLG FFGPLLVICL CYVLIVVKLK ASGVRVGSTR
RRSERKVTRM VVVVVLVFAG CWLPFFIVNI VNLAFALPEE PASAGLYFFV VVLSYANSCA
NPCLYGFLSD NLRQSFRKVL CLRKGYGAGA EDADATEPRP DPSSRLQEAT MPIRSCKANG
LMQTSKL
//
