ID Q8MVW6_NAEGR Unreviewed; 1952 AA.
AC Q8MVW6;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Basal body protein NBP-2 {ECO:0000313|EMBL:AAM90827.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|EMBL:AAM90827.1};
RN [1] {ECO:0000313|EMBL:AAM90827.1}
RP NUCLEOTIDE SEQUENCE.
RA Suh M.R., Lee J.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF463419; AAM90827.1; -; Genomic_DNA.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_52311; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.90.10.10; Bulb-type lectin domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR036426; Bulb-type_lectin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF235; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00181; EGF; 9.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1933..1951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 297..331
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 464..496
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 678..717
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 896..935
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1090..1856
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT REGION 347..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 321..330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 486..495
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 707..716
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 925..934
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1952 AA; 199357 MW; E9A4722546AD27BF CRC64;
MSIDTSKAQL WKTATIGIVL LTIFLSSLNG LVNANGTGPD YCSGRGFCSA TGDSCLCTTT
LTFNSSENAN TLKAGSNHTY YMLGSAGNEP AYYTNGGVNY FSRATYSNGQ LVITVNGETV
FSNDAHGFNN LVLQTDGSIA MCNSTFTDCT PLVSNVTATA STACNGTSPY YAFFRKDGLL
TVYDSIGKQC WSSESHASSV NYQDFNGTTC ENPWYYCNNT VSTSASVCSG HGSCTGGGCS
CHSGYNGTYC TNEATCGGIA QSSNSTCSGH GVCSFSGCTC NAPYYGSDCS LKYFICNGTH
STEPSVCNSH GQCTADNVCV CNAGYQGSYC QSVNGTTVDS SNGTISSNGT VSNNGTISSN
GTISNNGTSN NGTISNNGTI PSNGTISNNG TIPSNGTISN NGTISNNGTI SSNGTIPSNG
TISNNGTIPS NGTISNNGTI PSNGTIPNNG TSNNNGTSNN NGTVIDKCKQ ITCLNGGTCS
EGLCKCKPGY SGPFCDDKDP CLNVACNNGT CSGGKCTCFS GYTGAYCDQL IPTYSVNPAC
VNVMSSSATP FCAGAGVILP LYNVNLMSGA KNSSDASALL ASNLAKLDAQ ANSTYQVGSA
YNPKCVTADC LIHVKRYACY STFYSCLNTT ATATQWCRGA CEIMYDTVST IANMSYPKNS
TCNSFPQSNC YYGVYLPDTT TCFGKAIKAA DVCSGKGSCI AQDTCTCASG YSGSNCEKSV
CYSKVSSDSS VCSGKGSCVA PDTCTCKTGV TGAQCEIGTC NGKSEILGGC SFRGSCNATD
SCVCKGNFDA VSYCSKCKTG YVGSNSHVPV CYNTAATDST VCGGKGTCTA PNTCSCSSGY
SGTACQTFSC WGISRTDSSV CGGSARGKGI GPNKCECVSN WNNLNNTCTS CSPAYKGDTC
ATAVCTAADT CNSHGTCDAN FKCVCSGNFD GEFCSVCKSG YVGSSCDIVC SAASTCNSHG
SCTNTGSCTC SGNFDSSSNC ASGKCINGFK GDACNYKVDS SSFKFNANGD RITATIYNGI
KKQVPCSQII SNLDKLGSGP LCNLDGKSTL EIVLGSGATI VTGDSLTVYA LLGDSSSTVS
AVVAAGDFVA LAPTASLSAD KSLVSQVDIL SLNAFDSVSL DRRPLSFAWI CTAGPSSDDQ
TKLTTLISSS TLSGLRINMG TAGLSAGTYT VQVTVTSAFS LTSTKTVSFT VISQAAPTLS
IKEGLSTKFL IGSTGLITPV ISFPSCYSGS GTTTYSFALD GSVSKVSSLS VVTKDNLMVL
GSGYTNINQE GDYYFIITAS AASAQAVSVT VKVTAVAQPI SVSFSVPDMT QSKDDPVAFS
IIVKDPSSTS DSVTLSTTCT DSFGASCSTN PGSSASFSSS ITAGTYIFTT NATKGSRTAS
STLKVTVTDT SKDKIVRVSI TSNVDLSTVD PTRDLYLTYN SLDALSSPTF TWTSESGDTS
SSSLLVISKS NLVPGASYAV SLSVVDGVKS GSASVSFTVN APPTKGTFEA YPTSGVALSD
LFDLKCGNGW SDPQTPLKFQ FFFYDSANVK WNPLTEKTEQ QSTKVLLPQP ASGSVLMVKA
VVYDSLGAST ETQTNITITK PSAAAATSAL SAIASGKDTV TLAAASSAMS VIGVVDNPTP
EQKAAIQQAA ASIADAFLSQ QAKTEAVTSV SAASAENSLS FTASVSASVA KGLVSDSTTS
KVIESLANTT SAVTKSSGFS LSDSAVDGTT STANNFLTYI NSKGVSKRAF SNSDISNLNK
VFASVASIKT KDAVPDAPAA TVTANGVTTT SRKVNLATLN NLTQAMTGKN QIKIKSGISS
NAAFANSKSV SLTVKTTAST ATNSVTKAME FSLADGTTSL SVSSDSAIAD LVFETTKSLS
RSIQATTVLC KKVDSTGALT DASGCTVVIG TDGTATASVK STGIYLLVQQ TTASSSGGKV
VPDKSSKISA ASGIAWSVLC MMIVAIVLAI VQ
//
