ID   Q8Q9S2_9HIV1            Unreviewed;       197 AA.
AC   Q8Q9S2;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAL71404.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AAL71404.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAL71404.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAL71404.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12719565; DOI=10.1128/JVI.77.10.5721-5730.2003;
RA   Frenkel L.M., Wang Y., Learn G.H., McKernan J.L., Ellis G.M., Mohan K.M.,
RA   Holte S.E., De Vange S.M., Pawluk D.M., Melvin A.J., Lewis P.F.,
RA   Heath L.M., Beck I.A., Mahalanabis M., Naugler W.E., Tobin N.H.,
RA   Mullins J.I.;
RT   "Multiple viral genetic analyses detect low-level human immunodeficiency
RT   virus type 1 replication during effective highly active antiretroviral
RT   therapy.";
RL   J. Virol. 77:5721-5730(2003).
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DR   EMBL; AY077006; AAL71404.1; -; Genomic_DNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:AAL71404.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW   Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT   DOMAIN          21..197
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAL71404.1"
FT   NON_TER         197
FT                   /evidence="ECO:0000313|EMBL:AAL71404.1"
SQ   SEQUENCE   197 AA;  22969 MW;  E02AE1999586CB7A CRC64;
     WPLTEEKIKA LIEICTEMEK EGKISKIGPE NPYNTPVFAI KKKDSTKWRK VVDFRELNKR
     TQDFWEVQLG IPHPAGLKKK KSVTVLDVGD AYFSVPLDKD FRKYTAFTIP SINNETPGIR
     YQYNVLPQGW KGSPAIFQSS MTKILEPFRK QNPDMVIYQY MDDLYVGSDL EIGQHRTKIE
     ELREHLLKWG FTTPDKK
//