ID Q8RIK5_FUSNN Unreviewed; 264 AA.
AC Q8RIK5;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN OrderedLocusNames=FN1584 {ECO:0000313|EMBL:AAL93699.1};
OS Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Fusobacterium.
OX NCBI_TaxID=190304 {ECO:0000313|EMBL:AAL93699.1, ECO:0000313|Proteomes:UP000002521};
RN [1] {ECO:0000313|EMBL:AAL93699.1, ECO:0000313|Proteomes:UP000002521}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 /
RC KCTC 2640 / LMG 13131 / VPI 4355 {ECO:0000313|Proteomes:UP000002521};
RX PubMed=11889109; DOI=10.1128/JB.184.7.2005-2018.2002;
RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N., Overbeek R.;
RT "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT strain ATCC 25586.";
RL J. Bacteriol. 184:2005-2018(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
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DR EMBL; AE009951; AAL93699.1; -; Genomic_DNA.
DR RefSeq; NP_602400.1; NC_003454.1.
DR RefSeq; WP_011015684.1; NZ_CP028101.1.
DR AlphaFoldDB; Q8RIK5; -.
DR STRING; 190304.FN1584; -.
DR PaxDb; 190304-FN1584; -.
DR EnsemblBacteria; AAL93699; AAL93699; FN1584.
DR GeneID; 79782525; -.
DR KEGG; fnu:FN1584; -.
DR PATRIC; fig|190304.8.peg.76; -.
DR eggNOG; COG2367; Bacteria.
DR HOGENOM; CLU_031960_9_2_0; -.
DR InParanoid; Q8RIK5; -.
DR BioCyc; FNUC190304:G1FZS-88-MONOMER; -.
DR Proteomes; UP000002521; Chromosome.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Hydrolase {ECO:0000313|EMBL:AAL93699.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002521}.
FT DOMAIN 25..236
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 264 AA; 30104 MW; A97B5383E6B2555F CRC64;
MEKYTEWKKE IEKIISQVDG KICINFYDLD KKNGFSINGN EKVLSASMIK LLILAELMKK
VSENKFSLSD TITITNFMKT GGDGVLKELN AGHHFTLKEL ATLMIIVSDN QATNILIDFL
GMENINFLGK ELGLRETFLE RRMMDAEASK NGYDNYTSAD DISLLLKLIY QEKLINKETS
QLMLDILLRQ QQGERLQRYL PPDIKIAHKC GDLDNLENDG GIIWLGNKIY ILVVLTSGMS
NLQCRQTIGK ISKFVYDKME ESLE
//
