ID Q8RJT9_STREE Unreviewed; 316 AA.
AC Q8RJT9;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=N-acetylmuramoyl-L-alanine amidase {ECO:0000313|EMBL:CAD12114.1};
DE EC=3.5.1.28 {ECO:0000313|EMBL:CAD12114.1};
GN Name=lytA {ECO:0000313|EMBL:CAD12114.1};
OS Streptococcus pneumoniae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1313 {ECO:0000313|EMBL:CAD12114.1};
RN [1] {ECO:0000313|EMBL:CAD12114.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1078/1997 {ECO:0000313|EMBL:CAD12114.1};
RX PubMed=12089276; DOI=10.1128/JCM.40.7.2545-2554.2002;
RA Obregon V., Garcia P., Garcia E., Fenoll A., Lopez R., Garcia J.L.;
RT "Molecular peculiarities of the lytA gene isolated from clinical
RT pneumococcal strains that are bile insoluble.";
RL J. Clin. Microbiol. 40:2545-2554(2002).
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DR EMBL; AJ419981; CAD12114.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8RJT9; -.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:UniProtKB-EC.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd06583; PGRP; 1.
DR Gene3D; 2.10.270.10; Cholin Binding; 1.
DR Gene3D; 3.40.80.10; Peptidoglycan recognition protein-like; 1.
DR InterPro; IPR036505; Amidase/PGRP_sf.
DR InterPro; IPR002502; Amidase_domain.
DR InterPro; IPR018337; Cell_wall/Cho-bd_repeat.
DR Pfam; PF01510; Amidase_2; 1.
DR Pfam; PF01473; Choline_bind_1; 2.
DR Pfam; PF19127; Choline_bind_3; 1.
DR SMART; SM00644; Ami_2; 1.
DR SUPFAM; SSF69360; Cell wall binding repeat; 1.
DR PROSITE; PS51170; CW; 3.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CAD12114.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 10..151
FT /note="N-acetylmuramoyl-L-alanine amidase"
FT /evidence="ECO:0000259|SMART:SM00644"
FT REPEAT 196..215
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT REPEAT 217..237
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT REPEAT 238..257
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
SQ SEQUENCE 316 AA; 36625 MW; 17EE5EA76759D168 CRC64;
MEIDVSKLRT DLPQVGVQPY RQVHAHSTGN RNSTVQNEAD YHYRKDPELG FFSHVVGNGR
VMQVGPVDNG AWDVGGGWNA EGYAQVELIE SHESKEEFLI DYRLYIELLR NLSDEAGIPK
TLDTDDLAGI KTHEYCTNNQ PDNNSDHIDP YPYLAKWGIS REQFKQDIEN GLTIEAGWQQ
NDTGTWYVHS DGSYPKDKFE KVNGTWYYFD GSGYMLADRW KKHIDGNWYW FDQSGEMATG
WKKIAEKWYY FDREGAMKTG WIKYKETWYY LDSQNGDMVS NAFVKSNDGW YYLKEDGTIA
DRPEFTVEPE GLITVK
//
