ID Q8RKD5_ECOLX Unreviewed; 432 AA.
AC Q8RKD5;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Periplasmic phosphoanhydride phosphohydrolase {ECO:0000313|EMBL:AAA00007.1};
GN Name=appA {ECO:0000313|EMBL:AAA00007.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AAA00007.1};
RN [1] {ECO:0000313|EMBL:AAA00007.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2168385;
RA Dassa J., Marck C., Boquet P.L.;
RT "The complete nucleotide sequence of the Escherichia coli gene appA reveals
RT significant homology between pH 2.5 acid phosphatase and glucose-1-
RT phosphatase.";
RL J. Bacteriol. 172:5497-5500(1990).
RN [2] {ECO:0000313|EMBL:AAA00007.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1429631;
RA Ostanin K., Harms E.H., Stevis P.E., Kuciel R., Zhou M.-M., van Etten R.L.;
RT "Overexpression, site-directed mutagenesis, and mechanism of Escherichia
RT coli acid phosphatase.";
RL J. Biol. Chem. 267:22830-22836(1992).
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; L03375; AAA00007.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8RKD5; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 2.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF110; ACID PHOSPHATASE 1, ISOFORM B; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AAA00007.1}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..432
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004312900"
SQ SEQUENCE 432 AA; 46991 MW; 951F393EA9A1A47C CRC64;
MKAILIPFLS LLIPLTPQSA FAQSEPELKL ESVVIVSRHG VRAPTKATQL MQDVTPDAWP
TWPVKLGWLT PRGGELIAYL GHYQRQRLVA DGLLAKKGCP QSGQVAIIAD VDERTRKTGE
AFAAGLAPDC AITVHTQADT SSPDPLFNPL KTGVCQLDNA NVTDAILSRA GGSIADFTGH
RQTAFRELER VLNFPQSNLC LKREKQDESC SLTQALPSEL KVSADNVSLT GAVSLASMLT
EIFLLQQAQG MPEPGWGRIT DSHQWNTLLS LHNAQFYLLQ RTPEVARSRA TPLLDLIKTA
LTPHPPQKQA YGVTLPTSVL FIAGADTNLA NLGGALELNW TLPGQPDNTP PGGELVFERW
RRLSDNSQWI QVSLVFQTLQ QMRDKTPLSL NTPPGEVKLT LAGCEERNAQ GMCSLAGFTQ
IVNEARIPAC SL
//
