ID Q8RKD8_ECOLX Unreviewed; 432 AA.
AC Q8RKD8;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Periplasmic phosphoanhydride phosphohydrolase {ECO:0000313|EMBL:AAA00004.1};
GN Name=appA {ECO:0000313|EMBL:AAA00004.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AAA00004.1};
RN [1] {ECO:0000313|EMBL:AAA00004.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2168385;
RA Dassa J., Marck C., Boquet P.L.;
RT "The complete nucleotide sequence of the Escherichia coli gene appA reveals
RT significant homology between pH 2.5 acid phosphatase and glucose-1-
RT phosphatase.";
RL J. Bacteriol. 172:5497-5500(1990).
RN [2] {ECO:0000313|EMBL:AAA00004.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1429631;
RA Ostanin K., Harms E.H., Stevis P.E., Kuciel R., Zhou M.-M., van Etten R.L.;
RT "Overexpression, site-directed mutagenesis, and mechanism of Escherichia
RT coli acid phosphatase.";
RL J. Biol. Chem. 267:22830-22836(1992).
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; L03372; AAA00004.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8RKD8; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 2.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF110; ACID PHOSPHATASE 1, ISOFORM B; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AAA00004.1}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..432
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004314191"
SQ SEQUENCE 432 AA; 46972 MW; 9A85536B57FCCFB5 CRC64;
MKAILIPFLS LLIPLTPQSA FAQSEPELKL ESVVIVSRHG VAAPTKATQL MQDVTPDAWP
TWPVKLGWLT PRGGELIAYL GHYQRQRLVA DGLLAKKGCP QSGQVAIIAD VDERTRKTGE
AFAAGLAPDC AITVHTQADT SSPDPLFNPL KTGVCQLDNA NVTDAILSRA GGSIADFTGH
RQTAFRELER VLNFPQSNLC LKREKQDESC SLTQALPSEL KVSADNVSLT GAVSLASMLT
EIFLLQQAQG MPEPGWGRIT DSHQWNTLLS LHNAQFYLLQ RTPEVARSRA TPLLDLIKTA
LTPHPPQKQA YGVTLPTSVL FIAGHDTNLA NLGGALELNW TLPGQPDNTP PGGELVFERW
RRLSDNSQWI QVSLVFQTLQ QMRDKTPLSL NTPPGEVKLT LAGCEERNAQ GMCSLAGFTQ
IVNEARIPAC SL
//