ID Q8SDF8_BPDPK Unreviewed; 173 AA.
AC Q8SDF8;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
OS Pseudomonas phage phiKZ.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Phikzvirus; Phikzvirus phiKZ.
OX NCBI_TaxID=2905945 {ECO:0000313|EMBL:AAL82905.1, ECO:0000313|Proteomes:UP000002098};
OH NCBI_TaxID=287; Pseudomonas aeruginosa.
RN [1] {ECO:0000313|EMBL:AAL82905.1, ECO:0000313|Proteomes:UP000002098}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11916376; DOI=10.1006/jmbi.2001.5396;
RA Mesyanzhinov V.V., Robben J., Grymonprez B., Kostyuchenko V.A.,
RA Bourkaltseva M.V., Sykilinda N.N., Krylov V.N., Volckaert G.;
RT "The genome of bacteriophage phiKZ of Pseudomonas aeruginosa.";
RL J. Mol. Biol. 317:1-19(2002).
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|RuleBase:RU004474}.
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DR EMBL; AF399011; AAL82905.1; -; Genomic_DNA.
DR RefSeq; NP_803570.1; NC_004629.1.
DR GeneID; 1258469; -.
DR KEGG; vg:1258469; -.
DR OrthoDB; 9577at10239; -.
DR Proteomes; UP000002098; Genome.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AAL82905.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002098}.
FT DOMAIN 2..173
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 173 AA; 19699 MW; 12C17109A9D7B953 CRC64;
MAIKLIVAHD LNGVIGYNNL LPWHIPEDLA FFKEMTTGCC VIMGKNTFLS LGSKPLPNRN
NIVVSSSLYR NGNYPVAYDN KLGVLPNLSA AIVYATHFNK ETGKDVWIIG GSQLYKEVIE
KDILDEMYIT TVKMEIDNSS CVYFPKEIIK WDKWKSTIIK ETDLCTYTHW IKT
//
