ID Q8TGC9_LACKL Unreviewed; 553 AA.
AC Q8TGC9;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00019988};
DE EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
DE AltName: Full=Glucosylceramide synthase {ECO:0000256|ARBA:ARBA00031543};
DE AltName: Full=UDP-glucose ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00032575};
DE AltName: Full=UDP-glucose:N-acylsphingosine D-glucosyltransferase {ECO:0000256|ARBA:ARBA00031017};
OS Lachancea kluyveri (Yeast) (Saccharomyces kluyveri).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=4934 {ECO:0000313|EMBL:BAB85841.1};
RN [1] {ECO:0000313|EMBL:BAB85841.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IFO 1685 {ECO:0000313|EMBL:BAB85841.1};
RX PubMed=12702269; DOI=10.1016/S1567-1356(02)00127-7;
RA Takakuwa N., Kinoshita M., Oda Y., Ohnishi M.;
RT "Existence of cerebroside in Saccharomyces kluyveri and its related
RT species.";
RL FEMS Yeast Res. 2:533-538(2002).
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR EMBL; AB080772; BAB85841.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TGC9; -.
DR CAZy; GT21; Glycosyltransferase Family 21.
DR UniPathway; UPA00222; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAB85841.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..553
FT /note="Ceramide glucosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004315187"
FT TRANSMEM 56..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 553 AA; 62693 MW; 457216C0A54FC3ED CRC64;
MMTLPTASII GMSTLSLLIL ALFIAPSQEG LIPPAATSVT SDKKDAHPTT TQSGSLQWYL
GLIGVIWYLI VLLLGYTGWV EVMRKFSQKK KLPKPNSKRE PVSIIRPCKG IDTEMLQRLE
SCILQEYPKD KFEVLFCVEN ATDLCIPIIK QLIEKYPDYD LKLLISSAVD EKPIDYFGPN
PKINNLAKAY RHAAYDIVWV LDSNVWVSPG TLARSVRSLE ESLDNGLPTH GRPVVLTHHV
PLAISISDRK SLSPSARLDE MFLFSSHAKF YVAFNKASIA PCINGKSNLY RRSSLDKAVA
LIGTGKKSTD LFRDKEIQSE ARIIELKNQN RVPHEHASFL EVTSSDGQLQ ERTIECTRHF
HGIEFFSTYI GEDNMIGTAL WDMLGGRTGM TGDVVVQPLK FGTRDDGLRN YINRRVRWLR
VRKYMVLAAT LLEPTTESIV IGLMGSFGIS ALIGGRMSIV FSCHMILWCL TDWLQYKVLM
DNLYQDECLH DLPQFLKEHG HRRPLCDWLK IWLLRELCAL PIWVEAMCGS VIYWRNKPFK
IKRDLTAEAL NVM
//
