ID Q8TUI8_METAC Unreviewed; 845 AA.
AC Q8TUI8;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=HTH arsR-type domain-containing protein {ECO:0000259|PROSITE:PS50987};
GN OrderedLocusNames=MA_0079 {ECO:0000313|EMBL:AAM03533.1};
OS Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS C2A).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM03533.1, ECO:0000313|Proteomes:UP000002487};
RN [1] {ECO:0000313|EMBL:AAM03533.1, ECO:0000313|Proteomes:UP000002487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC {ECO:0000313|Proteomes:UP000002487};
RX PubMed=11932238; DOI=10.1101/gr.223902;
RA Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA Lander E., Metcalf W.W., Birren B.;
RT "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT physiological diversity.";
RL Genome Res. 12:532-542(2002).
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DR EMBL; AE010299; AAM03533.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TUI8; -.
DR STRING; 188937.MA_0079; -.
DR EnsemblBacteria; AAM03533; AAM03533; MA_0079.
DR KEGG; mac:MA_0079; -.
DR HOGENOM; CLU_009017_1_0_2; -.
DR InParanoid; Q8TUI8; -.
DR Proteomes; UP000002487; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR44943; CELLULOSE SYNTHASE OPERON PROTEIN C; 1.
DR PANTHER; PTHR44943:SF4; TPR REPEAT-CONTAINING PROTEIN MJ0263; 1.
DR Pfam; PF12895; ANAPC3; 1.
DR SMART; SM00418; HTH_ARSR; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50987; HTH_ARSR_2; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002487};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT DOMAIN 329..423
FT /note="HTH arsR-type"
FT /evidence="ECO:0000259|PROSITE:PS50987"
FT REPEAT 577..610
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 611..644
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 845 AA; 98060 MW; D623865B08C9FB6F CRC64;
MKMISTSKSI MENLIFTPRC SKIGGGFSME RSKGTMSDCI NCNSSIAVST SISVSSNNPK
GITLYRYSPE NVPPEILKNI FVGRDDLFEK TFKDLETAGK NKTPRFYLIV GSRGIGKSHF
LIMLYYRIKQ ELSSLYIPIK FAEEEYSVYR ASDFFLRVLQ ERNEDISGIL SLTDEDEILG
ASLDRLKEIA KKENKTYLIF VENLHEVFRQ FDAKEVQKLR SIFQKYDFFS VIASSPIIFP
GVAESEEPFY NFFRIQHLRE LTIDEIKILL KKIAEIEGNI EFLENFKKCE PRIEGISHLT
GGSPRLIIFF YELITRDNFD DMERVFFKIL DEHTPYYQEI FQLLTGQRRL IFDAVISSES
PITPKQISEK TRVDASVVIT QLRRLEKDGY VLSRPSGRET YYEVRERLFR LWRDMRQPLG
RNRISVFLDF LKLWYTSEEQ KELFEKKFYL LGSGNKEVLK DLCYYVEVLP DEYKTKALLN
LIPKIIKFEE WEEADHDIQK LKESASKSTD SDLKAKSLIL ESLSNYKHDK TALETFKKTL
NFDTKDYSDL LDSGNVTIYK KLLKAFDKIL DLNPEDEYAL SRKGNALIIL ERYEEATEVL
DSILDLNPED EYALLRKGYV LNHLERYEEA VEVFTKLLNL NPENEYALSG KGHTLFSLER
YEEAIEMFVK VKNITSNESF KFESTLELIE AYLSLDQVAG AIAEIESIKS KISDQTPNLI
EKFLDVCWEI VFKELRTGNL GSGRKYINAI FDLEHLLTKE IFEASMINFF KTAIDSGELE
ILKISIGEIS ELKVDDYLGL LKPIIKAVEI IETKDVQKYY KLQVEEKEIV ADLVRKISKS
EDLLP
//
