ID   Q8TYP8_METKA            Unreviewed;       420 AA.
AC   Q8TYP8;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase fused to uncharacterized archaeal protein {ECO:0000313|EMBL:AAM01462.1};
GN   Name=cysH {ECO:0000313|EMBL:AAM01462.1};
GN   OrderedLocusNames=MK0245 {ECO:0000313|EMBL:AAM01462.1};
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanomada group; Methanopyri; Methanopyrales;
OC   Methanopyraceae; Methanopyrus.
OX   NCBI_TaxID=190192 {ECO:0000313|EMBL:AAM01462.1, ECO:0000313|Proteomes:UP000001826};
RN   [1] {ECO:0000313|EMBL:AAM01462.1, ECO:0000313|Proteomes:UP000001826}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938
RC   {ECO:0000313|Proteomes:UP000001826};
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
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DR   EMBL; AE009439; AAM01462.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TYP8; -.
DR   STRING; 190192.MK0245; -.
DR   PaxDb; 190192-MK0245; -.
DR   EnsemblBacteria; AAM01462; AAM01462; MK0245.
DR   KEGG; mka:MK0245; -.
DR   HOGENOM; CLU_632571_0_0_2; -.
DR   InParanoid; Q8TYP8; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01713; PAPS_reductase; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR002500; PAPS_reduct.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43196; SULFATE ADENYLYLTRANSFERASE SUBUNIT 2; 1.
DR   PANTHER; PTHR43196:SF1; SULFATE ADENYLYLTRANSFERASE SUBUNIT 2; 1.
DR   Pfam; PF01507; PAPS_reduct; 1.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001826}.
FT   DOMAIN          237..407
FT                   /note="Phosphoadenosine phosphosulphate reductase"
FT                   /evidence="ECO:0000259|Pfam:PF01507"
SQ   SEQUENCE   420 AA;  46847 MW;  4793B42D9798DD31 CRC64;
     MHLHVLVRAR KDASAVESAL ERYYPDWEWK VETLGGERDP SWIVGLARER FEGSDALWKV
     LLLGRRSYPG RGRVVWMEGW SAVNVGKAEV RNARLTEIVD GIELGRAAPR LSVAFRRVPE
     LRRGRLLTEN QDADTMLRWG KFTETIAELA GEELPPGAYF SLRKPGNPPE EVLYDASGKP
     ILRIITPDEG EPSVSVLGDG EPFDSRAFVR ENRETLENLF EDAVDFLGGV AEEFDVLFVP
     VSGGKDSTCC LAIAVETTDR LGIDVEAVYV DTGYDLGRDV VEDVGAALGV DIKHVDVSDA
     FERGLRERKP THENRWCTGV KLSGIKKVLK DLEGDVLLVV GDRDAESRRR RLRPPVHRNR
     LLDVPEVNPV KGWGGAEVLG TLFRLGLPVS ELYEIGFYRL GCSVCPSLTA WERALMELSR
//