ID Q8VF81_MOUSE Unreviewed; 310 AA.
AC Q8VF81;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 163.
DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
GN Name=Or2q1 {ECO:0000313|Ensembl:ENSMUSP00000068823.4,
GN ECO:0000313|MGI:MGI:3030284};
GN Synonyms=Olfr450 {ECO:0000313|EMBL:AAP70960.1,
GN ECO:0000313|MGI:MGI:3030284};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAL61316.1};
RN [1] {ECO:0000313|EMBL:AAL61316.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [2] {ECO:0000313|EMBL:AAL61316.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3] {ECO:0000313|EMBL:AAL61316.1}
RP NUCLEOTIDE SEQUENCE.
RA Adams M.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAP70960.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [5] {ECO:0000313|EMBL:AAP70960.1}
RP NUCLEOTIDE SEQUENCE.
RA Sanders K.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|Ensembl:ENSMUSP00000068823.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000068823.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [7] {ECO:0000313|EMBL:ALI87933.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6 {ECO:0000313|EMBL:ALI87933.1};
RA Mainland J.D., Li Y.R., Zhou T., Liu W.L.L., Matsunami H.;
RT "Human Olfactory Receptor Responses to Odorants.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Ensembl:ENSMUSP00000068823.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000068823.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AY073653; AAL61316.1; -; Genomic_DNA.
DR EMBL; AY317557; AAP70960.1; -; Genomic_DNA.
DR EMBL; KP290776; ALI87933.1; -; Genomic_DNA.
DR RefSeq; NP_666656.1; NM_146445.1.
DR STRING; 10090.ENSMUSP00000151908; -.
DR PaxDb; 10090-ENSMUSP00000068823; -.
DR DNASU; 258437; -.
DR Ensembl; ENSMUST00000067503.4; ENSMUSP00000068823.4; ENSMUSG00000054431.5.
DR Ensembl; ENSMUST00000218832.2; ENSMUSP00000151908.2; ENSMUSG00000054431.5.
DR GeneID; 258437; -.
DR KEGG; mmu:258437; -.
DR UCSC; uc009bry.1; mouse.
DR AGR; MGI:3030284; -.
DR CTD; 258437; -.
DR MGI; MGI:3030284; Or2q1.
DR VEuPathDB; HostDB:ENSMUSG00000054431; -.
DR eggNOG; ENOG502TAH2; Eukaryota.
DR GeneTree; ENSGT01090000260044; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR OMA; QKSIPFY; -.
DR OrthoDB; 5259681at2759; -.
DR TreeFam; TF337251; -.
DR BioGRID-ORCS; 258437; 2 hits in 71 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 6.
DR GO; GO:0016020; C:membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26453:SF219; OLFACTORY RECEPTOR; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU363047};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363047};
KW Olfaction {ECO:0000256|ARBA:ARBA00022725, ECO:0000256|RuleBase:RU363047};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU363047};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363047}.
FT TRANSMEM 27..50
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 62..80
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 132..156
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 198..217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 238..262
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 274..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT DOMAIN 43..291
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 310 AA; 34473 MW; ECC4D82E3EFD8CF3 CRC64;
MGQEFINQTW VNEFILLGLS SDRNTQVFLF VLVLAMYVVT VVGNTLILFL IRLDIRLHTP
MYFFLSVLSI VDLCYGNSIA PQMLAHLVSA QKLIPFHSCV FQLYISLALG GSEFFLLGAM
SYDRYVAVCH PLHYTVIMDG GVCLGLAASC LMAGFFNSLM ETVITFRLPL CHNVINHFAC
ETLAVLRLAC VDISFNKVMV AISGFLVIML PCCLVLFSYT RIVIAILRIR STQGRHKAFG
TCASHLTVVC MCFGATIFTY LGPRSASSED KEKMVALFYA VVAPTLNPVI YSLRNKEVMA
ALTKLVEKLR
//
