ID Q8WLP3_SALSA Unreviewed; 235 AA.
AC Q8WLP3;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=MHC class II alpha {ECO:0000313|EMBL:AAL40122.1};
DE Flags: Precursor;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:AAL40122.1};
RN [1] {ECO:0000313|EMBL:AAL40122.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Head kidney {ECO:0000313|EMBL:AAL40122.1};
RA Grimholt U., Arnet E.F., Lie O.;
RT "The major histocompatibility complex class II alpha chain in atlantic
RT salmon (Salmo salar).";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; L77086; AAL40122.1; -; mRNA.
DR AlphaFoldDB; Q8WLP3; -.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF86; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW MHC II {ECO:0000256|ARBA:ARBA00023182}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..235
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004316000"
FT DOMAIN 97..192
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 235 AA; 25904 MW; 12F642024C7558BE CRC64;
MKTSVIVLIL CWQVYAEHKV LHIDLVITGC SDSDGLDMYG LDGEEMWYAD FNKQEGVVAL
PPFADPFTFP GFYEQAVGNQ GVCKGNLAKC IKAYKNPEEK IDPPHSSIYP RDDVDLGVEN
TLICHVSGFF PAPVRVRWTR NNQNLTEGVR LSTPYPNADF TLNQFSSLPF TPEEGDIYGC
TVEHKGLAEP LTRIWEPEVI QPSVGPDVFC GVGLTLGLLG VAAGTFFLIK GNQCN
//
