ID Q8WMN2_SHEEP Unreviewed; 221 AA.
AC Q8WMN2;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Hepatocyte nuclear factor 1-beta {ECO:0000256|ARBA:ARBA00039291};
DE AltName: Full=Transcription factor 2 {ECO:0000256|ARBA:ARBA00041233};
DE Flags: Fragment;
GN Name=vHNF1 {ECO:0000313|EMBL:CAC84557.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|EMBL:CAC84557.1};
RN [1] {ECO:0000313|EMBL:CAC84557.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Small intestine {ECO:0000313|EMBL:CAC84557.1};
RX PubMed=11606209; DOI=10.1046/j.0014-2956.2001.02488.x;
RA Vayro S., Wood I.S., Dyer J., Shirazi-Beechey S.P.;
RT "Transcriptional regulation of the ovine intestinal Na+/glucose co-
RT transporter SGLT1 gene.";
RL Eur. J. Biochem. 268:5460-5470(2001).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR EMBL; AJ311788; CAC84557.1; -; mRNA.
DR AlphaFoldDB; Q8WMN2; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR11568; HEPATOCYTE NUCLEAR FACTOR 1; 1.
DR PANTHER; PTHR11568:SF2; HEPATOCYTE NUCLEAR FACTOR 1-BETA; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
FT DOMAIN 4..85
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 6..86
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 99..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAC84557.1"
FT NON_TER 221
FT /evidence="ECO:0000313|EMBL:CAC84557.1"
SQ SEQUENCE 221 AA; 24210 MW; 4A25712F6EA510E1 CRC64;
PTNKKMRRNR FKWGPASQQI LYQAYDRQKN PSKEEREALV EECNRAECLQ RGVSPSKAHG
LGSNLVTEVR VYNWFANRRK EEAFRQKLAM DAYSSSQTHG LNTLLSHGSP HHQPSTSPPN
KLPGVRYSQQ GSNEVTSSST ISHHGNSAMV TSQSVLQQVS PASLDPGHNL LSPDGKMISV
SGGGLPPVST LTNIHSLSHH NPQQSQNLIM TPLSGVMAIA Q
//
