ID Q8X216_NEUCS Unreviewed; 462 AA.
AC Q8X216;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Mitochondrial export translocase Oxa1 {ECO:0000313|EMBL:AAL30813.1};
GN Name=oxa1 {ECO:0000313|EMBL:AAL30813.1};
OS Neurospora crassa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=5141 {ECO:0000313|EMBL:AAL30813.1};
RN [1] {ECO:0000313|EMBL:AAL30813.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11823466; DOI=10.1074/jbc.M112099200;
RA Nargang F.E., Preuss M., Neupert W., Herrmann J.M.;
RT "The Oxa1 protein forms a homooligomeric complex and is an essential part
RT of the mitochondrial export translocase in Neurospora crassa.";
RL J. Biol. Chem. 277:12846-12853(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003945}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003945}.
CC Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family.
CC {ECO:0000256|ARBA:ARBA00009877, ECO:0000256|RuleBase:RU003945}.
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DR EMBL; AF435863; AAL30813.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8X216; -.
DR VEuPathDB; FungiDB:NCU01102; -.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR CDD; cd20069; 5TM_Oxa1-like; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR PANTHER; PTHR12428:SF66; MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003945};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 142..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..343
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
SQ SEQUENCE 462 AA; 50323 MW; 48E6E88B36E9E5F0 CRC64;
MLPSRGLLRS TPALGLARAS FKAPSSRQFG TALRSSFPQG SRRIGGPLGT TATAAASHQL
LSSLRQVRYA STGPDAAVAA DAAAAAAAAP SSSPVDAVAA TPVELTGSDL LNLPEQIGFL
KTLGLDYGWG VTSMMQWLTE HVYVYSGLPW WATLAAVAAI VRVAIFKPSL GASQESQKMQ
DLNKNPKYAA IMAKVKEASF DTTKQNDLVK YRQEMALMTK NAGINYFKVF IPFIQVPIGF
GMFRLIRGMA ALPVESLETG GTLWFPDLTV ADPYFALPIA SACLFVASMR KPIPYMAPQQ
ARMMKSMGLV LVPVSIFATA WLPAALQWYF LVSAIGQYFQ ASIFHLPAFR RWVGLPELVP
GGMRGPSPFA KAAAPSSTIQ YVAPRTMDTT ATPVDSGSIL GDIKDSSNFV KEKLEDWKKK
NDNTNIHSRA KEYEERRALE EHEAYLARLE LKKQKQKGRK NH
//
