ID Q8XMT9_CLOPE Unreviewed; 706 AA.
AC Q8XMT9;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=CPE0599 {ECO:0000313|EMBL:BAB80305.1};
OS Clostridium perfringens (strain 13 / Type A).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=195102 {ECO:0000313|EMBL:BAB80305.1, ECO:0000313|Proteomes:UP000000818};
RN [1] {ECO:0000313|EMBL:BAB80305.1, ECO:0000313|Proteomes:UP000000818}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13 / Type A {ECO:0000313|Proteomes:UP000000818};
RX PubMed=11792842; DOI=10.1073/pnas.022493799;
RA Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT eater.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; BA000016; BAB80305.1; -; Genomic_DNA.
DR RefSeq; WP_011009920.1; NC_003366.1.
DR AlphaFoldDB; Q8XMT9; -.
DR STRING; 195102.gene:10489860; -.
DR KEGG; cpe:CPE0599; -.
DR HOGENOM; CLU_010312_4_0_9; -.
DR Proteomes; UP000000818; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF17; DNA HELICASE IV; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000000818}.
FT DOMAIN 204..563
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 225..232
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 706 AA; 82992 MW; 85B3A4E1B3B5478A CRC64;
MTDKKDIEFL VEEKKLEEVS NILNEEMLSY INKRKFVTQY ILDYRKNAVE EYKDDEDKLI
EYFDHERYVK EQAFTTIDKK LKELTILKES PYFGRVTFND LEFDQKDTLY VGRFGVTPEG
SYEPVIVDWR APVASLFYHG SLGEASYTSP DGPIKCDIEG RRQIIVKKGE LKGVFDSAID
VKDDILQMVL SNNSSDKLKD VIMTIQQEQD EIIRKERTSN IVVNGVAGSG KTTIALHRVA
YLLYNYRKEL EDKVIILGPN GIFMEYISQV LPSLGEVGVK QETFASFALK EMDSELYIMS
FDKYLEKILS EDIEFIEDAK YKNSYEIIED LDNLVKEMDK DYFHVEDVKY FGDLVISKEE
IEEMFNKHYE YMPLFRRSEK IKRIILSKIK DKRDEKVWEL NEELRKEKEK LTPEELLIEE
NNLEFRRKLR IREIVKEVMD SRAKLDRWIS REDVLDIYDR FNGNKKEYTI NDLAPILYLA
IKLEGKKATK DYRHVVIDEA QDYSPLQFKV VRELTGTKYF TVVGDVNQRL IKYSDLAPMM
ELGKIFDDVN PEIYNLNKSY RSTYEIMEYA NKYLDEDRII PIVRHGKPVE EIEFHNDEEL
SESIIESLKE FSNEGLESIA IITRDKEELE KVYNLISNKV HLVKFDNEDV LYKGGNVIIP
SYFAKGLEFD GVIIVDNGSS KDENEDLIKY IMSTRALHRL KEIQFK
//
