ID   Q8YFI8_BRUME            Unreviewed;       362 AA.
AC   Q8YFI8;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   SubName: Full=Farnesyl pyrophosphate synthetase / geranyltranstransferase {ECO:0000313|EMBL:AAL52713.1};
DE            EC=2.5.1.1 {ECO:0000313|EMBL:AAL52713.1};
DE            EC=2.5.1.10 {ECO:0000313|EMBL:AAL52713.1};
GN   OrderedLocusNames=BMEI1532 {ECO:0000313|EMBL:AAL52713.1};
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914 {ECO:0000313|EMBL:AAL52713.1, ECO:0000313|Proteomes:UP000000419};
RN   [1] {ECO:0000313|EMBL:AAL52713.1, ECO:0000313|Proteomes:UP000000419}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094
RC   {ECO:0000313|Proteomes:UP000000419};
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.J.,
RA   Haselkorn R., Kyrpides N., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC       {ECO:0000256|ARBA:ARBA00006706, ECO:0000256|RuleBase:RU004466}.
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DR   EMBL; AE008917; AAL52713.1; -; Genomic_DNA.
DR   PIR; AF3443; AF3443.
DR   AlphaFoldDB; Q8YFI8; -.
DR   KEGG; bme:BMEI1532; -.
DR   eggNOG; COG0142; Bacteria.
DR   Proteomes; UP000000419; Chromosome I.
DR   GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004337; F:geranyltranstransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd00685; Trans_IPPS_HT; 1.
DR   Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR033749; Polyprenyl_synt_CS.
DR   PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR   PANTHER; PTHR12001:SF87; OCTAPRENYL DIPHOSPHATE SYNTHASE; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR   SUPFAM; SSF48576; Terpenoid synthases; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
PE   3: Inferred from homology;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Transferase {ECO:0000256|RuleBase:RU004466, ECO:0000313|EMBL:AAL52713.1}.
SQ   SEQUENCE   362 AA;  38738 MW;  3C103467A056CF6A CRC64;
     MWSKRKVGAL ARPDRAHAAP GEMALGVVLN LDGKMKQEGS VQPLVDLTRA DMARVNELIL
     SRAGSDVEMI PEVANHLISS GGKRLRPMMT LASARMFGYE GDGHVRLATS VEFMHTATLL
     HDDVVDESDL RRGKSTARTI WGNQASVLVG DFLLGQAFKM MVDVGSLDAL DVLATSASII
     AEGEVMQLAA AKNMETTEDE YLAVIKAKTA ALFSAAAEVG PIIAGAQRSD RAALRDYGLN
     LGLAFQLVDD ALDYGGSAAD LGKNTGDDFR EGKITLPVIL SYRRGTDEER AFWKGAIEGG
     ASDDASLQKA IGLMMKHGAI ADTVQRARHF GEIARDALAP LKASPQKDAL IEVVDFCISR
     VN
//