ID Q8Z2E4_SALTI Unreviewed; 258 AA.
AC Q8Z2E4; A0A0C9DVK6; Q7C660;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 153.
DE SubName: Full=L-lactate dehydrogenase operon regulator {ECO:0000313|EMBL:CAD03301.1};
DE SubName: Full=Transcriptional regulator LldR {ECO:0000313|EMBL:EBG5395715.1};
GN Name=lctR {ECO:0000313|EMBL:CAD03301.1};
GN Synonyms=lldR {ECO:0000313|EMBL:CAD03301.1};
GN OrderedLocusNames=STY4103 {ECO:0000313|EMBL:CAD03301.1}, t3826
GN {ECO:0000313|EMBL:AAO71307.1};
GN ORFNames=CAJ76_00620 {ECO:0000313|EMBL:EDG8855469.1}, CAJ80_00140
GN {ECO:0000313|EMBL:EDG8899931.1}, CAJ85_14325
GN {ECO:0000313|EMBL:EDG8893568.1}, CAL67_17045
GN {ECO:0000313|EMBL:EDG8934335.1}, CB224_00350
GN {ECO:0000313|EMBL:EDH5799205.1}, CC884_15720
GN {ECO:0000313|EMBL:EDI0959192.1}, CC907_13360
GN {ECO:0000313|EMBL:EDI0994583.1}, CC972_01020
GN {ECO:0000313|EMBL:EDI1137330.1}, D4Z37_15585
GN {ECO:0000313|EMBL:EBS6527242.1}, D6Q30_19760
GN {ECO:0000313|EMBL:EBS1100464.1}, DKA88_14975
GN {ECO:0000313|EMBL:EBW2553788.1}, DNM71_00640
GN {ECO:0000313|EMBL:EBV0718888.1}, DNV09_09420
GN {ECO:0000313|EMBL:EBV1032905.1}, DS261_00640
GN {ECO:0000313|EMBL:EBX7032092.1}, DUQ91_00640
GN {ECO:0000313|EMBL:EBS0135480.1}, DUV11_00640
GN {ECO:0000313|EMBL:EBS5362664.1}, DVG36_13645
GN {ECO:0000313|EMBL:EBY2834666.1}, EBC38_00665
GN {ECO:0000313|EMBL:EBZ4080450.1}, EID90_15440
GN {ECO:0000313|EMBL:EBZ9856232.1}, ELQ62_12465
GN {ECO:0000313|EMBL:ECA4924735.1}, EU445_00625
GN {ECO:0000313|EMBL:ECB1383137.1}, EVI00_03210
GN {ECO:0000313|EMBL:ECB2191822.1}, F9R11_03165
GN {ECO:0000313|EMBL:EDB3134619.1}, F9Y21_03125
GN {ECO:0000313|EMBL:EDB3625236.1}, FI137_18175
GN {ECO:0000313|EMBL:EBG5395715.1}, G2227_03070
GN {ECO:0000313|EMBL:HAE0479917.1}, G2244_00625
GN {ECO:0000313|EMBL:HAE0415184.1}, G3982_004369
GN {ECO:0000313|EMBL:HAE3630611.1}, G3V49_003649
GN {ECO:0000313|EMBL:HAE1998563.1}, G4I71_000152
GN {ECO:0000313|EMBL:HAE6053060.1}, G4L28_004356
GN {ECO:0000313|EMBL:HAE6909592.1}, G4P30_000125
GN {ECO:0000313|EMBL:HAE7596874.1}, G4Y41_000022
GN {ECO:0000313|EMBL:HAE9013515.1}, G4Y55_000610
GN {ECO:0000313|EMBL:HAE9577943.1}, G9264_003955
GN {ECO:0000313|EMBL:HAF7400374.1}, G9C68_003138
GN {ECO:0000313|EMBL:HAF0687496.1}, G9X37_002780
GN {ECO:0000313|EMBL:HAF7362161.1}, GDI29_03165
GN {ECO:0000313|EMBL:EDH3994122.1}, GND71_000125
GN {ECO:0000313|EMBL:HAE7808428.1}, K3U68_18615
GN {ECO:0000313|EMBL:QZA28838.1}, ZZ17_00025
GN {ECO:0000313|EMBL:ECV8214181.1};
OS Salmonella typhi.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370 {ECO:0000313|EMBL:CAD03301.1, ECO:0000313|Proteomes:UP000000541};
RN [1] {ECO:0000313|EMBL:CAD03301.1, ECO:0000313|Proteomes:UP000000541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18 {ECO:0000313|EMBL:CAD03301.1,
RC ECO:0000313|Proteomes:UP000000541};
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.,
RA Rutherford K., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2] {ECO:0000313|EMBL:AAO71307.1, ECO:0000313|Proteomes:UP000002670}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2 {ECO:0000313|Proteomes:UP000002670}, and Ty2
RC {ECO:0000313|EMBL:AAO71307.1};
RX PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA Deng W., Liou S.R., Plunkett G.III., Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
RN [3] {ECO:0000313|EMBL:HAE0415184.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09-1703 {ECO:0000313|EMBL:HAE3630611.1}, 09-1978
RC {ECO:0000313|EMBL:HAE6053060.1}, 09-1979
RC {ECO:0000313|EMBL:HAE7596874.1}, 10-1436
RC {ECO:0000313|EMBL:HAE1998563.1}, 11-2088
RC {ECO:0000313|EMBL:HAE6909592.1}, 12-0098
RC {ECO:0000313|EMBL:HAF7400374.1}, 12-0437
RC {ECO:0000313|EMBL:HAF7362161.1}, 12-2005
RC {ECO:0000313|EMBL:HAE9013515.1}, 13-0747
RC {ECO:0000313|EMBL:HAF0687496.1}, 13-7562
RC {ECO:0000313|EMBL:HAE9577943.1}, IP E.88.374
RC {ECO:0000313|EMBL:HAE7808428.1},
RC Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC {ECO:0000313|EMBL:HAE0415184.1}, and
RC Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC {ECO:0000313|EMBL:HAE0479917.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [4] {ECO:0000313|EMBL:HAE1998563.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09-1703 {ECO:0000313|EMBL:HAE3630611.1}, 09-1978
RC {ECO:0000313|EMBL:HAE6053060.1}, 09-1979
RC {ECO:0000313|EMBL:HAE7596874.1}, 10-1436
RC {ECO:0000313|EMBL:HAE1998563.1}, 11-2088
RC {ECO:0000313|EMBL:HAE6909592.1}, 12-0098
RC {ECO:0000313|EMBL:HAF7400374.1}, 12-0437
RC {ECO:0000313|EMBL:HAF7362161.1}, 12-2005
RC {ECO:0000313|EMBL:HAE9013515.1}, 13-0747
RC {ECO:0000313|EMBL:HAF0687496.1}, 13-7562
RC {ECO:0000313|EMBL:HAE9577943.1}, IP E.88.374
RC {ECO:0000313|EMBL:HAE7808428.1},
RC Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC {ECO:0000313|EMBL:HAE0415184.1}, and
RC Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC {ECO:0000313|EMBL:HAE0479917.1};
RG NCBI Pathogen Detection Project;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:EBS0135480.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=116585 {ECO:0000313|EMBL:EDG8934335.1}, 132015
RC {ECO:0000313|EMBL:EDG8899931.1}, 14549
RC {ECO:0000313|EMBL:ECV8214181.1}, 186520
RC {ECO:0000313|EMBL:EDG8893568.1}, 189261
RC {ECO:0000313|EMBL:EDG8855469.1}, 257355
RC {ECO:0000313|EMBL:EBW2553788.1}, 338438
RC {ECO:0000313|EMBL:EDI1137330.1}, 339489
RC {ECO:0000313|EMBL:EDI0959192.1}, 348081
RC {ECO:0000313|EMBL:EDI0994583.1}, 365365
RC {ECO:0000313|EMBL:EDH5799205.1}, 524805
RC {ECO:0000313|EMBL:EBY2834666.1}, 531284
RC {ECO:0000313|EMBL:EBV1032905.1}, 539099
RC {ECO:0000313|EMBL:EBV0718888.1}, 550116
RC {ECO:0000313|EMBL:EBX7032092.1}, 550675
RC {ECO:0000313|EMBL:ECB1383137.1}, 550679
RC {ECO:0000313|EMBL:EBS5362664.1}, 568336
RC {ECO:0000313|EMBL:EBS0135480.1}, 588927
RC {ECO:0000313|EMBL:EBS6527242.1}, 606246
RC {ECO:0000313|EMBL:EBS1100464.1}, 619925
RC {ECO:0000313|EMBL:EBZ4080450.1}, 643219
RC {ECO:0000313|EMBL:EBZ9856232.1}, 656788
RC {ECO:0000313|EMBL:ECA4924735.1}, 673629
RC {ECO:0000313|EMBL:ECB2191822.1}, 731618
RC {ECO:0000313|EMBL:EBG5395715.1}, 814947
RC {ECO:0000313|EMBL:EDB3134619.1}, 815592
RC {ECO:0000313|EMBL:EDB3625236.1}, and 824494
RC {ECO:0000313|EMBL:EDH3994122.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QZA28838.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ISP2825 {ECO:0000313|EMBL:QZA28838.1};
RA Lee G.Y., Song J.;
RT "Complete Genome Sequence of Salmonella enterica Serovar Typhi Strain
RT ISP2825.";
RL Submitted (AUG-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AE014613; AAO71307.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD03301.1; -; Genomic_DNA.
DR EMBL; AAFJDY010000034; EBG5395715.1; -; Genomic_DNA.
DR EMBL; AAGUIA010000001; EBS0135480.1; -; Genomic_DNA.
DR EMBL; AAGULE010000049; EBS1100464.1; -; Genomic_DNA.
DR EMBL; AAGVVD010000001; EBS5362664.1; -; Genomic_DNA.
DR EMBL; AAGWES010000017; EBS6527242.1; -; Genomic_DNA.
DR EMBL; AAHEBT010000001; EBV0718888.1; -; Genomic_DNA.
DR EMBL; AAHEEH010000011; EBV1032905.1; -; Genomic_DNA.
DR EMBL; AAHHUX010000016; EBW2553788.1; -; Genomic_DNA.
DR EMBL; AAHLZU010000001; EBX7032092.1; -; Genomic_DNA.
DR EMBL; AAHNRO010000015; EBY2834666.1; -; Genomic_DNA.
DR EMBL; AAHRAJ010000001; EBZ4080450.1; -; Genomic_DNA.
DR EMBL; AAHSWZ010000022; EBZ9856232.1; -; Genomic_DNA.
DR EMBL; AAHUNO010000015; ECA4924735.1; -; Genomic_DNA.
DR EMBL; AAHWPO010000001; ECB1383137.1; -; Genomic_DNA.
DR EMBL; AAHWWI010000002; ECB2191822.1; -; Genomic_DNA.
DR EMBL; AAKUKE010000001; ECV8214181.1; -; Genomic_DNA.
DR EMBL; AALNBT010000002; EDB3134619.1; -; Genomic_DNA.
DR EMBL; AALNGB010000002; EDB3625236.1; -; Genomic_DNA.
DR EMBL; AAMFQS010000001; EDG8855469.1; -; Genomic_DNA.
DR EMBL; AAMFQZ010000016; EDG8893568.1; -; Genomic_DNA.
DR EMBL; AAMFRD010000001; EDG8899931.1; -; Genomic_DNA.
DR EMBL; AAMFRJ010000055; EDG8934335.1; -; Genomic_DNA.
DR EMBL; AAMHNJ010000002; EDH3994122.1; -; Genomic_DNA.
DR EMBL; AAMICL010000001; EDH5799205.1; -; Genomic_DNA.
DR EMBL; AAMJUX010000023; EDI0959192.1; -; Genomic_DNA.
DR EMBL; AAMJVG010000019; EDI0994583.1; -; Genomic_DNA.
DR EMBL; AAMJWL010000001; EDI1137330.1; -; Genomic_DNA.
DR EMBL; DAAQQG010000001; HAE0415184.1; -; Genomic_DNA.
DR EMBL; DAAQQU010000002; HAE0479917.1; -; Genomic_DNA.
DR EMBL; DAARDQ010000061; HAE1998563.1; -; Genomic_DNA.
DR EMBL; DAARRK010000062; HAE3630611.1; -; Genomic_DNA.
DR EMBL; DAASLV010000001; HAE6053060.1; -; Genomic_DNA.
DR EMBL; DAASSY010000061; HAE6909592.1; -; Genomic_DNA.
DR EMBL; DAASYX010000001; HAE7596874.1; -; Genomic_DNA.
DR EMBL; DAATAS010000001; HAE7808428.1; -; Genomic_DNA.
DR EMBL; DAATOU010000001; HAE9013515.1; -; Genomic_DNA.
DR EMBL; DAATPQ010000002; HAE9577943.1; -; Genomic_DNA.
DR EMBL; DAATYW010000016; HAF0687496.1; -; Genomic_DNA.
DR EMBL; DAAWCE010000059; HAF7362161.1; -; Genomic_DNA.
DR EMBL; DAAWDS010000053; HAF7400374.1; -; Genomic_DNA.
DR EMBL; CP080960; QZA28838.1; -; Genomic_DNA.
DR RefSeq; NP_458233.1; NC_003198.1.
DR RefSeq; WP_000636695.1; NZ_WSUN01000004.1.
DR AlphaFoldDB; Q8Z2E4; -.
DR STRING; 220341.gene:17587945; -.
DR KEGG; stt:t3826; -.
DR KEGG; sty:STY4103; -.
DR PATRIC; fig|220341.7.peg.4189; -.
DR eggNOG; COG2186; Bacteria.
DR HOGENOM; CLU_017584_9_5_6; -.
DR OMA; SFVVDFH; -.
DR OrthoDB; 5450856at2; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.20.120.530; GntR ligand-binding domain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011711; GntR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43537:SF18; L-LACTATE DEHYDROGENASE OPERON REGULATORY PROTEIN-RELATED; 1.
DR PANTHER; PTHR43537; TRANSCRIPTIONAL REGULATOR, GNTR FAMILY; 1.
DR Pfam; PF07729; FCD; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00895; FCD; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF48008; GntR ligand-binding domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 6..74
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 258 AA; 29084 MW; 111D54550CBCD3BB CRC64;
MIVMPKRLSD EIASRVRALI EEQNLEAGMK LPAERQLALQ LGVSRNSLRE ALAKLVSEGV
LVSRRGGGTF VRWQHETWSE QNIVQPLKML MANDPDYSFD ILEARHAIEA STAWHAAMRA
TAADKEKIRL CFDATLSEDP DLASQADVRF HLAIAEASHN VVLLQTMRGF FDVLQSSVKQ
SRQRMYLVPP VFSKLTEQHQ AVLDAILDGN AEGARKAMMA HLSFVHTTIK RFDEDQARQA
RITRLPGDHN EMTRENKS
//
