ID Q8Z3F8_SALTI Unreviewed; 778 AA.
AC Q8Z3F8; A0A0C9CTS6; Q7C6Z4;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 180.
DE RecName: Full=Aerobic respiration control sensor protein {ECO:0000256|PIRNR:PIRNR003182};
DE EC=2.7.13.3 {ECO:0000256|PIRNR:PIRNR003182};
GN Name=arcB {ECO:0000313|EMBL:CAD07845.1};
GN OrderedLocusNames=STY3507 {ECO:0000313|EMBL:CAD07845.1}, t3245
GN {ECO:0000313|EMBL:AAO70781.1};
GN ORFNames=CAJ76_05460 {ECO:0000313|EMBL:EDG8856366.1}, CAJ80_02330
GN {ECO:0000313|EMBL:EDG8900342.1}, CAJ85_03530
GN {ECO:0000313|EMBL:EDG8891569.1}, CAL67_04090
GN {ECO:0000313|EMBL:EDG8931912.1}, CB224_03965
GN {ECO:0000313|EMBL:EDH5799881.1}, CC884_03620
GN {ECO:0000313|EMBL:EDI0956936.1}, CC907_02160
GN {ECO:0000313|EMBL:EDI0992500.1}, CC972_06525
GN {ECO:0000313|EMBL:EDI1138354.1}, D4Z37_01215
GN {ECO:0000313|EMBL:EBS6524599.1}, D6Q30_09455
GN {ECO:0000313|EMBL:EBS1098554.1}, DKA88_03900
GN {ECO:0000313|EMBL:EBW2551750.1}, DNM71_04885
GN {ECO:0000313|EMBL:EBV0719666.1}, DNV09_16520
GN {ECO:0000313|EMBL:EBV1034227.1}, DS261_04365
GN {ECO:0000313|EMBL:EBX7032780.1}, DUQ91_04370
GN {ECO:0000313|EMBL:EBS0136169.1}, DUV11_03185
GN {ECO:0000313|EMBL:EBS5363135.1}, DVG36_03715
GN {ECO:0000313|EMBL:EBY2832849.1}, EBC38_04245
GN {ECO:0000313|EMBL:EBZ4081117.1}, EID90_02375
GN {ECO:0000313|EMBL:EBZ9853814.1}, ELQ62_02235
GN {ECO:0000313|EMBL:ECA4922854.1}, EU445_04255
GN {ECO:0000313|EMBL:ECB1383814.1}, EVI00_05590
GN {ECO:0000313|EMBL:ECB2192265.1}, F9R11_05715
GN {ECO:0000313|EMBL:EDB3135097.1}, F9Y21_05480
GN {ECO:0000313|EMBL:EDB3625675.1}, FI137_01160
GN {ECO:0000313|EMBL:EBG5392552.1}, G2227_06670
GN {ECO:0000313|EMBL:HAE0480578.1}, G2244_04240
GN {ECO:0000313|EMBL:HAE0415859.1}, G3982_000375
GN {ECO:0000313|EMBL:HAE3626881.1}, G3V49_000740
GN {ECO:0000313|EMBL:HAE1995866.1}, G4I71_001345
GN {ECO:0000313|EMBL:HAE6054159.1}, G4L28_000219
GN {ECO:0000313|EMBL:HAE6905730.1}, G4P30_000574
GN {ECO:0000313|EMBL:HAE7597293.1}, G4Y41_000398
GN {ECO:0000313|EMBL:HAE9013872.1}, G4Y55_001320
GN {ECO:0000313|EMBL:HAE9578599.1}, G9264_000908
GN {ECO:0000313|EMBL:HAF7397545.1}, G9C68_000953
GN {ECO:0000313|EMBL:HAF0685471.1}, G9X37_000238
GN {ECO:0000313|EMBL:HAF7359780.1}, GDI29_05520
GN {ECO:0000313|EMBL:EDH3994561.1}, GND71_000847
GN {ECO:0000313|EMBL:HAE7809098.1}, K3U68_16350
GN {ECO:0000313|EMBL:QZA28454.1}, ZZ17_02380
GN {ECO:0000313|EMBL:ECV8214620.1};
OS Salmonella typhi.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370 {ECO:0000313|EMBL:CAD07845.1, ECO:0000313|Proteomes:UP000000541};
RN [1] {ECO:0000313|EMBL:CAD07845.1, ECO:0000313|Proteomes:UP000000541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18 {ECO:0000313|EMBL:CAD07845.1,
RC ECO:0000313|Proteomes:UP000000541};
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.,
RA Rutherford K., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2] {ECO:0000313|EMBL:AAO70781.1, ECO:0000313|Proteomes:UP000002670}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2 {ECO:0000313|Proteomes:UP000002670}, and Ty2
RC {ECO:0000313|EMBL:AAO70781.1};
RX PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA Deng W., Liou S.R., Plunkett G.III., Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
RN [3] {ECO:0000313|EMBL:HAE0415859.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09-1703 {ECO:0000313|EMBL:HAE3626881.1}, 09-1978
RC {ECO:0000313|EMBL:HAE6054159.1}, 09-1979
RC {ECO:0000313|EMBL:HAE7597293.1}, 10-1436
RC {ECO:0000313|EMBL:HAE1995866.1}, 11-2088
RC {ECO:0000313|EMBL:HAE6905730.1}, 12-0098
RC {ECO:0000313|EMBL:HAF7397545.1}, 12-0437
RC {ECO:0000313|EMBL:HAF7359780.1}, 12-2005
RC {ECO:0000313|EMBL:HAE9013872.1}, 13-0747
RC {ECO:0000313|EMBL:HAF0685471.1}, 13-7562
RC {ECO:0000313|EMBL:HAE9578599.1}, IP E.88.374
RC {ECO:0000313|EMBL:HAE7809098.1},
RC Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC {ECO:0000313|EMBL:HAE0415859.1}, and
RC Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC {ECO:0000313|EMBL:HAE0480578.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [4] {ECO:0000313|EMBL:EBS0136169.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=116585 {ECO:0000313|EMBL:EDG8931912.1}, 132015
RC {ECO:0000313|EMBL:EDG8900342.1}, 14549
RC {ECO:0000313|EMBL:ECV8214620.1}, 186520
RC {ECO:0000313|EMBL:EDG8891569.1}, 189261
RC {ECO:0000313|EMBL:EDG8856366.1}, 257355
RC {ECO:0000313|EMBL:EBW2551750.1}, 338438
RC {ECO:0000313|EMBL:EDI1138354.1}, 339489
RC {ECO:0000313|EMBL:EDI0956936.1}, 348081
RC {ECO:0000313|EMBL:EDI0992500.1}, 365365
RC {ECO:0000313|EMBL:EDH5799881.1}, 524805
RC {ECO:0000313|EMBL:EBY2832849.1}, 531284
RC {ECO:0000313|EMBL:EBV1034227.1}, 539099
RC {ECO:0000313|EMBL:EBV0719666.1}, 550116
RC {ECO:0000313|EMBL:EBX7032780.1}, 550675
RC {ECO:0000313|EMBL:ECB1383814.1}, 550679
RC {ECO:0000313|EMBL:EBS5363135.1}, 568336
RC {ECO:0000313|EMBL:EBS0136169.1}, 588927
RC {ECO:0000313|EMBL:EBS6524599.1}, 606246
RC {ECO:0000313|EMBL:EBS1098554.1}, 619925
RC {ECO:0000313|EMBL:EBZ4081117.1}, 643219
RC {ECO:0000313|EMBL:EBZ9853814.1}, 656788
RC {ECO:0000313|EMBL:ECA4922854.1}, 673629
RC {ECO:0000313|EMBL:ECB2192265.1}, 731618
RC {ECO:0000313|EMBL:EBG5392552.1}, 814947
RC {ECO:0000313|EMBL:EDB3135097.1}, 815592
RC {ECO:0000313|EMBL:EDB3625675.1}, and 824494
RC {ECO:0000313|EMBL:EDH3994561.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:HAE1995866.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09-1703 {ECO:0000313|EMBL:HAE3626881.1}, 09-1978
RC {ECO:0000313|EMBL:HAE6054159.1}, 09-1979
RC {ECO:0000313|EMBL:HAE7597293.1}, 10-1436
RC {ECO:0000313|EMBL:HAE1995866.1}, 11-2088
RC {ECO:0000313|EMBL:HAE6905730.1}, 12-0098
RC {ECO:0000313|EMBL:HAF7397545.1}, 12-0437
RC {ECO:0000313|EMBL:HAF7359780.1}, 12-2005
RC {ECO:0000313|EMBL:HAE9013872.1}, 13-0747
RC {ECO:0000313|EMBL:HAF0685471.1}, 13-7562
RC {ECO:0000313|EMBL:HAE9578599.1}, IP E.88.374
RC {ECO:0000313|EMBL:HAE7809098.1},
RC Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC {ECO:0000313|EMBL:HAE0415859.1}, and
RC Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC {ECO:0000313|EMBL:HAE0480578.1};
RG NCBI Pathogen Detection Project;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QZA28454.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ISP2825 {ECO:0000313|EMBL:QZA28454.1};
RA Lee G.Y., Song J.;
RT "Complete Genome Sequence of Salmonella enterica Serovar Typhi Strain
RT ISP2825.";
RL Submitted (AUG-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085,
CC ECO:0000256|PIRNR:PIRNR003182};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|PIRNR:PIRNR003182}; Multi-pass membrane protein
CC {ECO:0000256|PIRNR:PIRNR003182}.
CC -!- PTM: Activation requires a sequential transfer of a phosphate group
CC from a His in the primary transmitter domain, to an Asp in the receiver
CC domain and to a His in the secondary transmitter domain.
CC {ECO:0000256|PIRSR:PIRSR003182-50}.
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DR EMBL; AE014613; AAO70781.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD07845.1; -; Genomic_DNA.
DR EMBL; AAFJDY010000001; EBG5392552.1; -; Genomic_DNA.
DR EMBL; AAGUIA010000003; EBS0136169.1; -; Genomic_DNA.
DR EMBL; AAGULE010000014; EBS1098554.1; -; Genomic_DNA.
DR EMBL; AAGVVD010000002; EBS5363135.1; -; Genomic_DNA.
DR EMBL; AAGWES010000001; EBS6524599.1; -; Genomic_DNA.
DR EMBL; AAHEBT010000003; EBV0719666.1; -; Genomic_DNA.
DR EMBL; AAHEEH010000027; EBV1034227.1; -; Genomic_DNA.
DR EMBL; AAHHUX010000003; EBW2551750.1; -; Genomic_DNA.
DR EMBL; AAHLZU010000003; EBX7032780.1; -; Genomic_DNA.
DR EMBL; AAHNRO010000003; EBY2832849.1; -; Genomic_DNA.
DR EMBL; AAHRAJ010000003; EBZ4081117.1; -; Genomic_DNA.
DR EMBL; AAHSWZ010000002; EBZ9853814.1; -; Genomic_DNA.
DR EMBL; AAHUNO010000002; ECA4922854.1; -; Genomic_DNA.
DR EMBL; AAHWPO010000003; ECB1383814.1; -; Genomic_DNA.
DR EMBL; AAHWWI010000003; ECB2192265.1; -; Genomic_DNA.
DR EMBL; AAKUKE010000002; ECV8214620.1; -; Genomic_DNA.
DR EMBL; AALNBT010000003; EDB3135097.1; -; Genomic_DNA.
DR EMBL; AALNGB010000003; EDB3625675.1; -; Genomic_DNA.
DR EMBL; AAMFQS010000004; EDG8856366.1; -; Genomic_DNA.
DR EMBL; AAMFQZ010000003; EDG8891569.1; -; Genomic_DNA.
DR EMBL; AAMFRD010000002; EDG8900342.1; -; Genomic_DNA.
DR EMBL; AAMFRJ010000006; EDG8931912.1; -; Genomic_DNA.
DR EMBL; AAMHNJ010000003; EDH3994561.1; -; Genomic_DNA.
DR EMBL; AAMICL010000003; EDH5799881.1; -; Genomic_DNA.
DR EMBL; AAMJUX010000003; EDI0956936.1; -; Genomic_DNA.
DR EMBL; AAMJVG010000002; EDI0992500.1; -; Genomic_DNA.
DR EMBL; AAMJWL010000004; EDI1138354.1; -; Genomic_DNA.
DR EMBL; DAAQQG010000003; HAE0415859.1; -; Genomic_DNA.
DR EMBL; DAAQQU010000004; HAE0480578.1; -; Genomic_DNA.
DR EMBL; DAARDQ010000006; HAE1995866.1; -; Genomic_DNA.
DR EMBL; DAARRK010000002; HAE3626881.1; -; Genomic_DNA.
DR EMBL; DAASLV010000010; HAE6054159.1; -; Genomic_DNA.
DR EMBL; DAASSY010000001; HAE6905730.1; -; Genomic_DNA.
DR EMBL; DAASYX010000002; HAE7597293.1; -; Genomic_DNA.
DR EMBL; DAATAS010000003; HAE7809098.1; -; Genomic_DNA.
DR EMBL; DAATOU010000003; HAE9013872.1; -; Genomic_DNA.
DR EMBL; DAATPQ010000004; HAE9578599.1; -; Genomic_DNA.
DR EMBL; DAATYW010000003; HAF0685471.1; -; Genomic_DNA.
DR EMBL; DAAWCE010000003; HAF7359780.1; -; Genomic_DNA.
DR EMBL; DAAWDS010000006; HAF7397545.1; -; Genomic_DNA.
DR EMBL; CP080960; QZA28454.1; -; Genomic_DNA.
DR RefSeq; NP_457707.1; NC_003198.1.
DR RefSeq; WP_000809818.1; NZ_WSUR01000003.1.
DR AlphaFoldDB; Q8Z3F8; -.
DR SMR; Q8Z3F8; -.
DR STRING; 220341.gene:17587358; -.
DR KEGG; stt:t3245; -.
DR KEGG; sty:STY3507; -.
DR PATRIC; fig|220341.7.peg.3571; -.
DR eggNOG; COG0784; Bacteria.
DR eggNOG; COG2198; Bacteria.
DR eggNOG; COG5002; Bacteria.
DR HOGENOM; CLU_000445_114_15_6; -.
DR OMA; AMLEQYI; -.
DR OrthoDB; 9770795at2; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00088; HPT; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 1.10.287.970; His Kinase A (phosphoacceptor) domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.20.120.160; HPT domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR027460; ArcB_TM_sf.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR040642; HKR_ArcB_TM.
DR InterPro; IPR036641; HPT_dom_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR InterPro; IPR014409; Sig_transdc_His_kin_hyb_ArcB.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43719:SF27; AEROBIC RESPIRATION CONTROL SENSOR PROTEIN ARCB; 1.
DR PANTHER; PTHR43719; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF18415; HKR_ArcB_TM; 1.
DR Pfam; PF01627; Hpt; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PIRSF; PIRSF003182; ArcB; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00073; HPT; 1.
DR SMART; SM00091; PAS; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47226; Histidine-containing phosphotransfer domain, HPT domain; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50894; HPT; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR003182};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519,
KW ECO:0000256|PIRNR:PIRNR003182};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR003182}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|PIRNR:PIRNR003182, ECO:0000313|EMBL:EBG5392552.1};
KW Membrane {ECO:0000256|PIRNR:PIRNR003182, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR003182};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|PIRSR:PIRSR003182-50};
KW Transcription {ECO:0000256|PIRNR:PIRNR003182};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR003182};
KW Transferase {ECO:0000256|PIRNR:PIRNR003182, ECO:0000313|EMBL:QZA28454.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012,
KW ECO:0000256|PIRNR:PIRNR003182}.
FT TRANSMEM 20..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..223
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 226..278
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 289..507
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 527..643
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 678..771
FT /note="HPt"
FT /evidence="ECO:0000259|PROSITE:PS50894"
FT COILED 77..153
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 292
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR003182-50"
FT MOD_RES 576
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PIRSR:PIRSR003182-50,
FT ECO:0000256|PROSITE-ProRule:PRU00169"
FT MOD_RES 717
FT /note="Phosphohistidine"
FT /evidence="ECO:0000256|PIRSR:PIRSR003182-50,
FT ECO:0000256|PROSITE-ProRule:PRU00110"
SQ SEQUENCE 778 AA; 87993 MW; CB28C3070B74CBCA CRC64;
MKQIRMLAQY YVDLMMKLGL VRFSMLLALA LVVLAIVVQM AVTMVLHGQV ESIDVIRSIF
FGLLITPWAV YFLSVVVEQL EESRQRLSRL VQKLEEMRER DLKLNVQLKD NIAQLNQEIA
DREKAEAELQ ETFEQLKVEI KEREEAQIQL EQQSSFLRSF LDASPDLVFY RNEDKEFSGC
NRAMELLTGK SEKQLVHLKP EDVYSPEAAE KVIETDEKVF RHNVSLTYEQ WLDYPDGRKA
CFEIRKVPYY DRVGKRHGLM GFGRDITERK RYQDALERAS RDKTTFISTI SHELRTPLNG
IVGLSRILLD TDLTAEQEKY LKTIHVSAVT LGNIFNDIID MDKMERRKVQ LDNQPVDFTS
FMADLENLSG LQAQQKGLRF VLEPTLPLPH KVITDGTRLR QILWNLISNA VKFTQQGQVT
VRARYDEGDM LHFEVEDSGI GIPQDEQDKI FAMYYQVKDS HGGKPATGTG IGLAVSRRLA
KNMGGDITVS SLPGKGSTFT LTVHAPAVAE EVEDAFDEDD MPLPALHVLL VEDIELNVIV
ARSVLEKLGN SVDVAMTGKA ALEMFAPGEY DLVLLDIQLP DMTGLDIARE LTRRHTREDL
PPLVALTANV LKDKKEYLDA GMDDVLSKPL SVPALTAMIK KFWDATDKEE STVTPEESDK
AQALLDIPML EQYIELVGPK LITDGLAVFE KMMLGYLSVL ESNLTARDKK GVVEEGHKIK
GAAGSVGLRH LQQLGQQIQS PDLPAWEDNV VEWIEEMKQE WQHDVAVLKA WVANAEKK
//
