UniProt: Q8Z7R7

Database: UniProt
Entry: Q8Z7R7_SALTI

LinkDB:  Q8Z7R7_SALTI 
Original site:  Q8Z7R7_SALTI

All links

Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (2)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (42)   
   EMBL (42)   
Protein domain (9)   
   InterPro (5)   
   Pfam (3)   
   PROSITE (1)   
Literature (3)   
   PubMed (3)   
All databases (63)   

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ID   Q8Z7R7_SALTI            Unreviewed;       684 AA.
AC   Q8Z7R7; A0A0C8TTT6; A0A0C9G8X0; Q7C965;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 150.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=helD {ECO:0000313|EMBL:CAD08201.1};
GN   OrderedLocusNames=STY1097 {ECO:0000313|EMBL:CAD08201.1}, t1845
GN   {ECO:0000313|EMBL:AAO69463.1};
GN   ORFNames=CAJ76_12090 {ECO:0000313|EMBL:EDG8857591.1}, CAJ80_12245
GN   {ECO:0000313|EMBL:EDG8902188.1}, CAJ85_18535
GN   {ECO:0000313|EMBL:EDG8894366.1}, CAL67_17450
GN   {ECO:0000313|EMBL:EDG8934413.1}, CB224_13075
GN   {ECO:0000313|EMBL:EDH5801561.1}, CC884_11485
GN   {ECO:0000313|EMBL:EDI0958393.1}, CC907_20535
GN   {ECO:0000313|EMBL:EDI0995936.1}, CC972_14500
GN   {ECO:0000313|EMBL:EDI1139827.1}, D4Z37_16250
GN   {ECO:0000313|EMBL:EBS6527368.1}, D6Q30_01125
GN   {ECO:0000313|EMBL:EBS1097018.1}, DKA88_15025
GN   {ECO:0000313|EMBL:EBW2553797.1}, DNM71_14415
GN   {ECO:0000313|EMBL:EBV0721419.1}, DNV09_09470
GN   {ECO:0000313|EMBL:EBV1032914.1}, DS261_15405
GN   {ECO:0000313|EMBL:EBX7034806.1}, DUQ91_06935
GN   {ECO:0000313|EMBL:EBS0136645.1}, DUV11_15290
GN   {ECO:0000313|EMBL:EBS5365361.1}, DVG36_13695
GN   {ECO:0000313|EMBL:EBY2834675.1}, EBC38_13860
GN   {ECO:0000313|EMBL:EBZ4082888.1}, EID90_12205
GN   {ECO:0000313|EMBL:EBZ9855625.1}, ELQ62_03420
GN   {ECO:0000313|EMBL:ECA4923082.1}, EU445_15120
GN   {ECO:0000313|EMBL:ECB1385807.1}, EVI00_06785
GN   {ECO:0000313|EMBL:ECB2192495.1}, F9R11_06900
GN   {ECO:0000313|EMBL:EDB3135325.1}, F9Y21_14970
GN   {ECO:0000313|EMBL:EDB3627430.1}, FI137_11045
GN   {ECO:0000313|EMBL:EBG5394390.1}, G2244_14075
GN   {ECO:0000313|EMBL:HAE0417662.1}, G3982_001253
GN   {ECO:0000313|EMBL:HAE3627704.1}, G3V49_003637
GN   {ECO:0000313|EMBL:HAE1998554.1}, G4I71_002685
GN   {ECO:0000313|EMBL:HAE6055400.1}, G4L28_004344
GN   {ECO:0000313|EMBL:HAE6909583.1}, G4P30_003183
GN   {ECO:0000313|EMBL:HAE7599720.1}, G4Y41_003157
GN   {ECO:0000313|EMBL:HAE9016447.1}, G4Y55_004071
GN   {ECO:0000313|EMBL:HAE9581168.1}, G9264_003872
GN   {ECO:0000313|EMBL:HAF7400298.1}, G9C68_004006
GN   {ECO:0000313|EMBL:HAF0688312.1}, G9X37_002684
GN   {ECO:0000313|EMBL:HAF7362072.1}, GDI29_15215
GN   {ECO:0000313|EMBL:EDH3996357.1}, GND71_001086
GN   {ECO:0000313|EMBL:HAE7809329.1}, K3U68_09325
GN   {ECO:0000313|EMBL:QZA31324.1}, ZZ17_10170
GN   {ECO:0000313|EMBL:ECV8216057.1};
OS   Salmonella typhi.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370 {ECO:0000313|EMBL:CAD08201.1, ECO:0000313|Proteomes:UP000000541};
RN   [1] {ECO:0000313|EMBL:CAD08201.1, ECO:0000313|Proteomes:UP000000541}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18 {ECO:0000313|EMBL:CAD08201.1,
RC   ECO:0000313|Proteomes:UP000000541};
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.,
RA   Rutherford K., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2] {ECO:0000313|EMBL:AAO69463.1, ECO:0000313|Proteomes:UP000002670}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2 {ECO:0000313|Proteomes:UP000002670}, and Ty2
RC   {ECO:0000313|EMBL:AAO69463.1};
RX   PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA   Deng W., Liou S.R., Plunkett G.III., Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
RN   [3] {ECO:0000313|EMBL:HAE0417662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=09-1703 {ECO:0000313|EMBL:HAE3627704.1}, 09-1978
RC   {ECO:0000313|EMBL:HAE6055400.1}, 09-1979
RC   {ECO:0000313|EMBL:HAE7599720.1}, 10-1436
RC   {ECO:0000313|EMBL:HAE1998554.1}, 11-2088
RC   {ECO:0000313|EMBL:HAE6909583.1}, 12-0098
RC   {ECO:0000313|EMBL:HAF7400298.1}, 12-0437
RC   {ECO:0000313|EMBL:HAF7362072.1}, 12-2005
RC   {ECO:0000313|EMBL:HAE9016447.1}, 13-0747
RC   {ECO:0000313|EMBL:HAF0688312.1}, 13-7562
RC   {ECO:0000313|EMBL:HAE9581168.1}, IP E.88.374
RC   {ECO:0000313|EMBL:HAE7809329.1}, and
RC   Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC   {ECO:0000313|EMBL:HAE0417662.1};
RX   PubMed=30286803;
RA   Souvorov A., Agarwala R., Lipman D.J.;
RT   "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL   Genome Biol. 19:153-153(2018).
RN   [4] {ECO:0000313|EMBL:HAE1998554.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=09-1703 {ECO:0000313|EMBL:HAE3627704.1}, 09-1978
RC   {ECO:0000313|EMBL:HAE6055400.1}, 09-1979
RC   {ECO:0000313|EMBL:HAE7599720.1}, 10-1436
RC   {ECO:0000313|EMBL:HAE1998554.1}, 11-2088
RC   {ECO:0000313|EMBL:HAE6909583.1}, 12-0098
RC   {ECO:0000313|EMBL:HAF7400298.1}, 12-0437
RC   {ECO:0000313|EMBL:HAF7362072.1}, 12-2005
RC   {ECO:0000313|EMBL:HAE9016447.1}, 13-0747
RC   {ECO:0000313|EMBL:HAF0688312.1}, 13-7562
RC   {ECO:0000313|EMBL:HAE9581168.1}, IP E.88.374
RC   {ECO:0000313|EMBL:HAE7809329.1}, and
RC   Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC   {ECO:0000313|EMBL:HAE0417662.1};
RG   NCBI Pathogen Detection Project;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:EBS0136645.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=116585 {ECO:0000313|EMBL:EDG8934413.1}, 132015
RC   {ECO:0000313|EMBL:EDG8902188.1}, 14549
RC   {ECO:0000313|EMBL:ECV8216057.1}, 186520
RC   {ECO:0000313|EMBL:EDG8894366.1}, 189261
RC   {ECO:0000313|EMBL:EDG8857591.1}, 257355
RC   {ECO:0000313|EMBL:EBW2553797.1}, 338438
RC   {ECO:0000313|EMBL:EDI1139827.1}, 339489
RC   {ECO:0000313|EMBL:EDI0958393.1}, 348081
RC   {ECO:0000313|EMBL:EDI0995936.1}, 365365
RC   {ECO:0000313|EMBL:EDH5801561.1}, 524805
RC   {ECO:0000313|EMBL:EBY2834675.1}, 531284
RC   {ECO:0000313|EMBL:EBV1032914.1}, 539099
RC   {ECO:0000313|EMBL:EBV0721419.1}, 550116
RC   {ECO:0000313|EMBL:EBX7034806.1}, 550675
RC   {ECO:0000313|EMBL:ECB1385807.1}, 550679
RC   {ECO:0000313|EMBL:EBS5365361.1}, 568336
RC   {ECO:0000313|EMBL:EBS0136645.1}, 588927
RC   {ECO:0000313|EMBL:EBS6527368.1}, 606246
RC   {ECO:0000313|EMBL:EBS1097018.1}, 619925
RC   {ECO:0000313|EMBL:EBZ4082888.1}, 643219
RC   {ECO:0000313|EMBL:EBZ9855625.1}, 656788
RC   {ECO:0000313|EMBL:ECA4923082.1}, 673629
RC   {ECO:0000313|EMBL:ECB2192495.1}, 731618
RC   {ECO:0000313|EMBL:EBG5394390.1}, 814947
RC   {ECO:0000313|EMBL:EDB3135325.1}, 815592
RC   {ECO:0000313|EMBL:EDB3627430.1}, and 824494
RC   {ECO:0000313|EMBL:EDH3996357.1};
RA   Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:QZA31324.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ISP2825 {ECO:0000313|EMBL:QZA31324.1};
RA   Lee G.Y., Song J.;
RT   "Complete Genome Sequence of Salmonella enterica Serovar Typhi Strain
RT   ISP2825.";
RL   Submitted (AUG-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; AE014613; AAO69463.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD08201.1; -; Genomic_DNA.
DR   EMBL; AAFJDY010000015; EBG5394390.1; -; Genomic_DNA.
DR   EMBL; AAGUIA010000005; EBS0136645.1; -; Genomic_DNA.
DR   EMBL; AAGULE010000001; EBS1097018.1; -; Genomic_DNA.
DR   EMBL; AAGVVD010000017; EBS5365361.1; -; Genomic_DNA.
DR   EMBL; AAGWES010000018; EBS6527368.1; -; Genomic_DNA.
DR   EMBL; AAHEBT010000016; EBV0721419.1; -; Genomic_DNA.
DR   EMBL; AAHEEH010000012; EBV1032914.1; -; Genomic_DNA.
DR   EMBL; AAHHUX010000017; EBW2553797.1; -; Genomic_DNA.
DR   EMBL; AAHLZU010000017; EBX7034806.1; -; Genomic_DNA.
DR   EMBL; AAHNRO010000016; EBY2834675.1; -; Genomic_DNA.
DR   EMBL; AAHRAJ010000016; EBZ4082888.1; -; Genomic_DNA.
DR   EMBL; AAHSWZ010000015; EBZ9855625.1; -; Genomic_DNA.
DR   EMBL; AAHUNO010000003; ECA4923082.1; -; Genomic_DNA.
DR   EMBL; AAHWPO010000017; ECB1385807.1; -; Genomic_DNA.
DR   EMBL; AAHWWI010000004; ECB2192495.1; -; Genomic_DNA.
DR   EMBL; AAKUKE010000013; ECV8216057.1; -; Genomic_DNA.
DR   EMBL; AALNBT010000004; EDB3135325.1; -; Genomic_DNA.
DR   EMBL; AALNGB010000016; EDB3627430.1; -; Genomic_DNA.
DR   EMBL; AAMFQS010000013; EDG8857591.1; -; Genomic_DNA.
DR   EMBL; AAMFQZ010000026; EDG8894366.1; -; Genomic_DNA.
DR   EMBL; AAMFRD010000019; EDG8902188.1; -; Genomic_DNA.
DR   EMBL; AAMFRJ010000057; EDG8934413.1; -; Genomic_DNA.
DR   EMBL; AAMHNJ010000016; EDH3996357.1; -; Genomic_DNA.
DR   EMBL; AAMICL010000015; EDH5801561.1; -; Genomic_DNA.
DR   EMBL; AAMJUX010000014; EDI0958393.1; -; Genomic_DNA.
DR   EMBL; AAMJVG010000047; EDI0995936.1; -; Genomic_DNA.
DR   EMBL; AAMJWL010000015; EDI1139827.1; -; Genomic_DNA.
DR   EMBL; DAAQQG010000015; HAE0417662.1; -; Genomic_DNA.
DR   EMBL; DAARDQ010000060; HAE1998554.1; -; Genomic_DNA.
DR   EMBL; DAARRK010000009; HAE3627704.1; -; Genomic_DNA.
DR   EMBL; DAASLV010000026; HAE6055400.1; -; Genomic_DNA.
DR   EMBL; DAASSY010000060; HAE6909583.1; -; Genomic_DNA.
DR   EMBL; DAASYX010000024; HAE7599720.1; -; Genomic_DNA.
DR   EMBL; DAATAS010000004; HAE7809329.1; -; Genomic_DNA.
DR   EMBL; DAATOU010000056; HAE9016447.1; -; Genomic_DNA.
DR   EMBL; DAATPQ010000025; HAE9581168.1; -; Genomic_DNA.
DR   EMBL; DAATYW010000027; HAF0688312.1; -; Genomic_DNA.
DR   EMBL; DAAWCE010000055; HAF7362072.1; -; Genomic_DNA.
DR   EMBL; DAAWDS010000050; HAF7400298.1; -; Genomic_DNA.
DR   EMBL; CP080960; QZA31324.1; -; Genomic_DNA.
DR   RefSeq; NP_455573.1; NC_003198.1.
DR   RefSeq; WP_000420526.1; NZ_WSUR01000013.1.
DR   AlphaFoldDB; Q8Z7R7; -.
DR   STRING; 220341.gene:17585079; -.
DR   KEGG; stt:t1845; -.
DR   KEGG; sty:STY1097; -.
DR   PATRIC; fig|220341.7.peg.1104; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_006494_0_1_6; -.
DR   OMA; LDFMTIH; -.
DR   OrthoDB; 5298826at2; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR022161; Helicase_IV_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12462; Helicase_IV_N; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          195..505
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         216..223
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   684 AA;  78038 MW;  5E9077CD302A198E CRC64;
     MELKATSLGK RLAQHPYDRA VILNAGVKVS GDRHEYLIPF NQLLAIHCKR GLVWGELEFV
     LPEDKVVRLH GTEWSETQQF HRYLDAHWRR WSQEMSDVAA QALQEQWARI SERTGGNQWL
     TREHVRGLEH EIRQTFAALP LPVSRLEEFA HCREIWRKCL AWLQDSEGSR QQHNQAYADA
     MLEAHADFFT QIESSPLNPS QARAVVNGES SLLVLAGAGS GKTSVLVARA GWLLARGQAD
     AGQILLLAFG RKAAEEMDER IRERLHTEEI TARTFHSLAL YIIQQGSKKA PVVSKLESDA
     TARHQLFLHT WRQQCSEKKA QAKGWRQWLE EEMQWVVPEG NFWDDETLQR RLAPRLDRWV
     SLMRMHGGAQ AEMIAGAPEE CRELFGKRIK LMAPLLKAWK SALKAENAVD FSGLIHQAMV
     ILEKGRFISP WKHILVDEFQ DISPQRAALL EALRKQNSQT TLFAVGDDWQ AIYRFSGAQL
     SLTTAFHQTF GEGEHCHLDT TYRFNSRIGD IANRFVQQNP HQLKKPLNSL TPGDKKAVTL
     LDESQLDALL DKLSGYAKED ERILVLARYH HLKPASLQKA ATRWPKLQID FMTIHASKGQ
     QADYVILVGL QEGNDGFPAP ARESIMESAL FPQVEDFPDA EERRLLYVAL TRARARVWLL
     FNKDNPSRFV EALKQLDVPV ARKP
//

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