ID Q8ZK53_SALTY Unreviewed; 645 AA.
AC Q8ZK53;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 2.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Sugar kinase {ECO:0000313|EMBL:AAL23250.2};
GN OrderedLocusNames=STM4430 {ECO:0000313|EMBL:AAL23250.2};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL23250.2, ECO:0000313|Proteomes:UP000001014};
RN [1] {ECO:0000313|EMBL:AAL23250.2, ECO:0000313|Proteomes:UP000001014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720
RC {ECO:0000313|Proteomes:UP000001014};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC {ECO:0000256|ARBA:ARBA00010688}.
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DR EMBL; AE006468; AAL23250.2; -; Genomic_DNA.
DR RefSeq; NP_453701.1; NC_003197.2.
DR RefSeq; WP_014343940.1; NC_003197.2.
DR AlphaFoldDB; Q8ZK53; -.
DR STRING; 99287.STM4430; -.
DR PaxDb; 99287-STM4430; -.
DR GeneID; 1255956; -.
DR KEGG; stm:STM4430; -.
DR BioCyc; SENT99287:STM4430-MONOMER; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01166; KdgK; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 2.20.150.10; putative 5-dehydro-2- deoxygluconokinase; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR018659; DUF2090.
DR InterPro; IPR030830; Myo_inos_IolC.
DR InterPro; IPR023314; Myo_inos_IolC-like_sf.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR NCBIfam; TIGR04382; myo_inos_iolC_N; 1.
DR PANTHER; PTHR43085:SF49; 5-DEHYDRO-2-DEOXYGLUCONOKINASE; 1.
DR PANTHER; PTHR43085; HEXOKINASE FAMILY MEMBER; 1.
DR Pfam; PF09863; DUF2090; 1.
DR Pfam; PF00294; PfkB; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:AAL23250.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001014};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 15..330
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
FT DOMAIN 333..641
FT /note="DUF2090"
FT /evidence="ECO:0000259|Pfam:PF09863"
SQ SEQUENCE 645 AA; 72160 MW; 3B5050F31AE7ED11 CRC64;
MSMNKAVSSE QKPLDVICLG RVAVDLYGQQ IGSRLEDMTT FAKYLGGSSG NVAYGTAIQG
LRSAMLARVG DEHMGRFVRE ELNRVGVDTQ CLLSDRDRLT ALVILGIKDQ DTFPLIFYRD
NCADMALTPE DIREDYIASS RALAVTGTHL SHPNTRAAVL KALEYAQKHG LRRALDIDYR
PVLWGLTSLG DGETRFIASS QVTEQLQQVL RHFDLIVGTE EEFHIAGGST DTLTALRRVR
QLTQAVLVCK RGALGCSVFE GNIADDWSQV KIHSGVRVDV LNVLGAGDAF MSGLLRGYLN
DESWEQACRY ANACGALVVS RHGCAPAMPT KKELDDYLAR EQSITRPDKD PRLNHLHRVT
TRKQHWPELC VFAFDHRKQL VDIANEVGAS ESAIPPLKML LLEGARQAAL EAGLQNNSGI
LADTTFGQQA LNDVTGQGWW IGRPVEMPGS YPLKLEHGDI GSQLVSWPQE HVVKCLVFYH
PLDAESVRLE QEALIDEVYR ACCQSGHDLL LEVILPRDAA DQNEQYYPQI VERFYQLGIL
PDWWKLPPLS PDRWREISQH IEHYDPECRG ILILGLDAPE SELKSGFAAA ADMPWVKGFA
VGRTIFGEPS RQWLGGQLND EQLIATVKQK YRMLIDYWRE YRPAR
//
