ID Q8ZM59_SALTY Unreviewed; 338 AA.
AC Q8ZM59;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=Zinc-binding dehydrogenase {ECO:0000313|EMBL:AAL21957.1};
GN OrderedLocusNames=STM3082 {ECO:0000313|EMBL:AAL21957.1};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL21957.1, ECO:0000313|Proteomes:UP000001014};
RN [1] {ECO:0000313|EMBL:AAL21957.1, ECO:0000313|Proteomes:UP000001014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720
RC {ECO:0000313|Proteomes:UP000001014};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; AE006468; AAL21957.1; -; Genomic_DNA.
DR RefSeq; NP_461998.1; NC_003197.2.
DR RefSeq; WP_000853913.1; NC_003197.2.
DR AlphaFoldDB; Q8ZM59; -.
DR STRING; 99287.STM3082; -.
DR PaxDb; 99287-STM3082; -.
DR GeneID; 1254605; -.
DR KEGG; stm:STM3082; -.
DR PATRIC; fig|99287.12.peg.3265; -.
DR HOGENOM; CLU_026673_11_0_6; -.
DR OMA; DLHFWKT; -.
DR PhylomeDB; Q8ZM59; -.
DR BioCyc; SENT99287:STM3082-MONOMER; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd08261; Zn_ADH7; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43401:SF3; L-GALACTONATE-5-DEHYDROGENASE; 1.
DR PANTHER; PTHR43401; L-THREONINE 3-DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001014};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 7..302
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 338 AA; 36498 MW; DBCF9C3FA35119A3 CRC64;
MKTLICNNPG NIEYIERDIP HLKDDEVLLK IKAVGICGTD IHAFAGRQPF FAYPRVLGHE
ICGVAEMLGK SCSTAKVGQR YSVIPCIPCG ACAACREGKT NCCENVSLYG VHQDGGFSEY
LAVREQNLVE LSDNLTDSAG ALVECFAISA HAVRRADVKP QQNIVVVGAG PIGLAAAAIA
KAKGARVAVA DIDAERRRLV AEKVGVATLD PSSDDYIDAL KACFSGELAG TVLDATGNKS
SMSRAVDLIR HGGKIVFIGL YIGELVIDDP TFHKKETTLL SSRNATREDF ECVIELMAQG
AISETMMKNQ EFDFYTFGNQ YQKNVVENKK LVKGVIKF
//
