ID HXA13_CHICK Reviewed; 290 AA.
AC Q90X25;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 08-NOV-2023, entry version 123.
DE RecName: Full=Homeobox protein Hox-A13;
GN Name=HOXA13;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA de Santa Barbara P., Roberts D.J.;
RT "Hoxa-13 function in the posterior gut endoderm.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific, AT-rich binding transcription factor which
CC is part of a developmental regulatory system that provides cells with
CC specific positional identities on the anterior-posterior axis.
CC {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as a homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; AY030050; AAK38163.1; -; mRNA.
DR RefSeq; NP_989470.1; NM_204139.1.
DR AlphaFoldDB; Q90X25; -.
DR BMRB; Q90X25; -.
DR SMR; Q90X25; -.
DR STRING; 9031.ENSGALP00000043198; -.
DR PaxDb; 9031-ENSGALP00000037022; -.
DR GeneID; 373934; -.
DR KEGG; gga:373934; -.
DR CTD; 3209; -.
DR VEuPathDB; HostDB:geneid_373934; -.
DR eggNOG; KOG0487; Eukaryota.
DR HOGENOM; CLU_059940_1_0_1; -.
DR InParanoid; Q90X25; -.
DR PhylomeDB; Q90X25; -.
DR PRO; PR:Q90X25; -.
DR Proteomes; UP000000539; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR022067; HoxA13_N.
DR PANTHER; PTHR45804:SF3; HOMEOBOX PROTEIN HOX-A13; 1.
DR PANTHER; PTHR45804; SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF12284; HoxA13_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..290
FT /note="Homeobox protein Hox-A13"
FT /id="PRO_0000200103"
FT DNA_BIND 224..283
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 290 AA; 31944 MW; F742BA75DF3E6E13 CRC64;
MFLYDNSLDE INKNMDGFHA GSNFAAAAAA NPCRNLMAHP APLAAPSAAA YTSSEAPAAG
MAEPAVKQCS PCSAAVQSSS GAALPYGYFG SGYYPCRMTH HNAIKSCAQP ASTFADKYMD
TSVSGEEFTS RAKEFAFYQG YAAGPYQPVP GYLDVPVVPT IGGPGEPRHD SLLPMDSYQP
WAITNGWNGQ VYCPKEQSQP PHLWKSTLPD VVSHPSDANS YRRGRKKRVP YTKVQLKELE
REYATNKFIT KDKRRRISAT TNLSERQVTI WFQNRRVKEK KVINKLKTTS
//
