ID Q91403_CHICK Unreviewed; 313 AA.
AC Q91403;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=Bone morphogenetic protein-7 {ECO:0000313|EMBL:AAB33846.1};
DE Flags: Fragment;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAB33846.1};
RN [1] {ECO:0000313|EMBL:AAB33846.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7893347;
RA Houston B., Thorp B.H., Burt D.W.;
RT "Molecular cloning and expression of bone morphogenetic protein-7 in the
RT chick epiphyseal growth plate.";
RL J. Mol. Endocrinol. 13:289-301(1994).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; S77477; AAB33846.1; -; mRNA.
DR PIR; I51284; I51284.
DR AlphaFoldDB; Q91403; -.
DR VEuPathDB; HostDB:geneid_395494; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19397; TGF_beta_BMP7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF135; BONE MORPHOGENETIC PROTEIN 7; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 185..313
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 173..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 313
FT /evidence="ECO:0000313|EMBL:AAB33846.1"
SQ SEQUENCE 313 AA; 35816 MW; C0A3739197DBAC8F CRC64;
ASLQDSNFLT EADMVMSFVN LVEHDREFHH QRCHYREFRF DLSRIPEGEA VTAAEFRIYK
DYIRERFDNE TFQISVYQVL QEHPGRDSDL FLLDSRTIWA AEEGWLVFDI TATSNHWVVN
PQHNLGLQLS VESIDGQSIN PKLAGLIGKH GPQNKQPFTV AFFKATEVHL RSIRSTGGKQ
RSQNRSKTPK NQEAFGMSNI AENSSSDQRQ ACKKHELYVS FRDLGWQDWI IAPEGYAAYY
CEGECAFPLN SYMNATNHAI VQTLVHFINP ETVPKPCCAP TQLNAISVLY FDDSSNVILK
KYRNMVVRAC GCH
//
