ID Q924B0_MOUSE Unreviewed; 277 AA.
AC Q924B0;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 168.
DE RecName: Full=Inositol-1-monophosphatase {ECO:0000256|RuleBase:RU364068};
DE EC=3.1.3.25 {ECO:0000256|RuleBase:RU364068};
GN Name=Impa1 {ECO:0000313|EMBL:AAK39515.1,
GN ECO:0000313|Ensembl:ENSMUSP00000068174.9,
GN ECO:0000313|MGI:MGI:1933158};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAK39515.1};
RN [1] {ECO:0000313|EMBL:BAC37259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37259.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31486.1}, Heart
RC {ECO:0000313|EMBL:BAE40356.1}, Hippocampus
RC {ECO:0000313|EMBL:BAC38823.1}, Small intestine
RC {ECO:0000313|EMBL:BAE35806.1}, Whole body
RC {ECO:0000313|EMBL:BAE35691.1}, and Wolffian duct includes surrounding
RC region {ECO:0000313|EMBL:BAC37259.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAC37259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37259.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31486.1}, Heart
RC {ECO:0000313|EMBL:BAE40356.1}, Hippocampus
RC {ECO:0000313|EMBL:BAC38823.1}, Small intestine
RC {ECO:0000313|EMBL:BAE35806.1}, Whole body
RC {ECO:0000313|EMBL:BAE35691.1}, and Wolffian duct includes surrounding
RC region {ECO:0000313|EMBL:BAC37259.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAC37259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37259.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31486.1}, Heart
RC {ECO:0000313|EMBL:BAE40356.1}, Hippocampus
RC {ECO:0000313|EMBL:BAC38823.1}, Small intestine
RC {ECO:0000313|EMBL:BAE35806.1}, Whole body
RC {ECO:0000313|EMBL:BAE35691.1}, and Wolffian duct includes surrounding
RC region {ECO:0000313|EMBL:BAC37259.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:AAK39515.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/J {ECO:0000313|EMBL:AAK39515.1};
RX PubMed=11418250; DOI=10.1016/S0378-1119(01)00502-9;
RA Shamir A., Sjoeholt G., Ebstein R.P., Agam G., Steen V.M.;
RT "Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol
RT monophosphatases.";
RL Gene 271:285-291(2001).
RN [5] {ECO:0000313|EMBL:BAC37259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37259.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31486.1}, Heart
RC {ECO:0000313|EMBL:BAE40356.1}, Hippocampus
RC {ECO:0000313|EMBL:BAC38823.1}, Small intestine
RC {ECO:0000313|EMBL:BAE35806.1}, Whole body
RC {ECO:0000313|EMBL:BAE35691.1}, and Wolffian duct includes surrounding
RC region {ECO:0000313|EMBL:BAC37259.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [6] {ECO:0000313|EMBL:BAC37259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37259.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31486.1}, Heart
RC {ECO:0000313|EMBL:BAE40356.1}, Hippocampus
RC {ECO:0000313|EMBL:BAC38823.1}, Small intestine
RC {ECO:0000313|EMBL:BAE35806.1}, Whole body
RC {ECO:0000313|EMBL:BAE35691.1}, and Wolffian duct includes surrounding
RC region {ECO:0000313|EMBL:BAC37259.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [7] {ECO:0000313|EMBL:BAC37259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37259.1};
RC TISSUE=Hippocampus {ECO:0000313|EMBL:BAC38823.1}, and Wolffian duct
RC includes surrounding region {ECO:0000313|EMBL:BAC37259.1};
RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA Hayashizaki Y.;
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AAH55722.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH55722.1};
RC TISSUE=Brain {ECO:0000313|EMBL:AAH55722.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9] {ECO:0000313|EMBL:BAE26456.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE26456.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31486.1}, Heart
RC {ECO:0000313|EMBL:BAE40356.1}, Small intestine
RC {ECO:0000313|EMBL:BAE35806.1}, and Whole body
RC {ECO:0000313|EMBL:BAE35691.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:BAC37259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37259.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31486.1}, Heart
RC {ECO:0000313|EMBL:BAE40356.1}, Hippocampus
RC {ECO:0000313|EMBL:BAC38823.1}, Small intestine
RC {ECO:0000313|EMBL:BAE35806.1}, Whole body
RC {ECO:0000313|EMBL:BAE35691.1}, and Wolffian duct includes surrounding
RC region {ECO:0000313|EMBL:BAC37259.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [11] {ECO:0000313|EMBL:BAC37259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37259.1};
RC TISSUE=Bone marrow {ECO:0000313|EMBL:BAE31486.1}, Heart
RC {ECO:0000313|EMBL:BAE40356.1}, Hippocampus
RC {ECO:0000313|EMBL:BAC38823.1}, Small intestine
RC {ECO:0000313|EMBL:BAE35806.1}, Whole body
RC {ECO:0000313|EMBL:BAE35691.1}, and Wolffian duct includes surrounding
RC region {ECO:0000313|EMBL:BAC37259.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [12] {ECO:0000313|Ensembl:ENSMUSP00000068174.9, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000068174.9,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [13] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [14] {ECO:0000313|Ensembl:ENSMUSP00000068174.9}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000068174.9};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate;
CC Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25;
CC Evidence={ECO:0000256|ARBA:ARBA00001033,
CC ECO:0000256|RuleBase:RU364068};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate;
CC Xref=Rhea:RHEA:29315, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58336; EC=3.1.3.94;
CC Evidence={ECO:0000256|ARBA:ARBA00035990};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946,
CC ECO:0000256|RuleBase:RU364068};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 2/2. {ECO:0000256|ARBA:ARBA00005152,
CC ECO:0000256|RuleBase:RU364068}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily.
CC {ECO:0000256|ARBA:ARBA00009759, ECO:0000256|RuleBase:RU364068}.
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DR EMBL; BC055722; AAH55722.1; -; mRNA.
DR EMBL; AH010671; AAK39515.1; -; Genomic_DNA.
DR EMBL; AF353728; AAK39515.1; JOINED; Genomic_DNA.
DR EMBL; AK078406; BAC37259.1; -; mRNA.
DR EMBL; AK083238; BAC38823.1; -; mRNA.
DR EMBL; AK145472; BAE26456.1; -; mRNA.
DR EMBL; AK147778; BAE28132.1; -; mRNA.
DR EMBL; AK152774; BAE31486.1; -; mRNA.
DR EMBL; AK160203; BAE35691.1; -; mRNA.
DR EMBL; AK160467; BAE35806.1; -; mRNA.
DR EMBL; AK168457; BAE40356.1; -; mRNA.
DR RefSeq; NP_001297362.1; NM_001310433.1.
DR RefSeq; NP_061352.2; NM_018864.6.
DR ProteomicsDB; 331194; -.
DR Antibodypedia; 25334; 186 antibodies from 27 providers.
DR DNASU; 55980; -.
DR Ensembl; ENSMUST00000065938.15; ENSMUSP00000068174.9; ENSMUSG00000027531.17.
DR GeneID; 55980; -.
DR KEGG; mmu:55980; -.
DR UCSC; uc008opo.2; mouse.
DR AGR; MGI:1933158; -.
DR CTD; 3612; -.
DR MGI; MGI:1933158; Impa1.
DR VEuPathDB; HostDB:ENSMUSG00000027531; -.
DR GeneTree; ENSGT00940000154634; -.
DR HOGENOM; CLU_044118_1_0_1; -.
DR OMA; ERGLHPW; -.
DR OrthoDB; 3685586at2759; -.
DR TreeFam; TF313194; -.
DR UniPathway; UPA00823; UER00788.
DR BioGRID-ORCS; 55980; 4 hits in 82 CRISPR screens.
DR ChiTaRS; Impa1; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR Bgee; ENSMUSG00000027531; Expressed in motor neuron and 258 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008934; F:inositol monophosphate 1-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0031403; F:lithium ion binding; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0030145; F:manganese ion binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR CDD; cd01639; IMPase; 1.
DR Gene3D; 3.40.190.80; -; 1.
DR Gene3D; 3.30.540.10; Fructose-1,6-Bisphosphatase, subunit A, domain 1; 1.
DR InterPro; IPR033942; IMPase.
DR InterPro; IPR020583; Inositol_monoP_metal-BS.
DR InterPro; IPR020552; Inositol_monoPase_Li-sen.
DR InterPro; IPR000760; Inositol_monophosphatase-like.
DR InterPro; IPR020550; Inositol_monophosphatase_CS.
DR PANTHER; PTHR20854; INOSITOL MONOPHOSPHATASE; 1.
DR PANTHER; PTHR20854:SF26; INOSITOL MONOPHOSPHATASE 1; 1.
DR Pfam; PF00459; Inositol_P; 1.
DR PRINTS; PR00377; IMPHPHTASES.
DR PRINTS; PR00378; LIIMPHPHTASE.
DR SUPFAM; SSF56655; Carbohydrate phosphatase; 1.
DR PROSITE; PS00629; IMP_1; 1.
DR PROSITE; PS00630; IMP_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|RuleBase:RU364068};
KW Lithium {ECO:0000256|ARBA:ARBA00022671};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU364068};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU364068};
KW Proteomics identification {ECO:0007829|EPD:Q924B0,
KW ECO:0007829|MaxQB:Q924B0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
SQ SEQUENCE 277 AA; 30429 MW; FB6915DCD7F477F6 CRC64;
MADPWQECMD YAVILARQAG EMIREALKNE MDVMIKSSPA DLVTVTDQKV EKMLMSSIKE
KYPCHSFIGE ESVAAGEKTV FTEQPTWVID PIDGTTNFVH RFPFVAVSIG FLVNKEMEFG
IVYSCVEDKM YTGRKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRKPE TLRIVLSNME
KLCSIPIHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD MAGAGIIVTE AGGVLMDVTG
GPFDLMSRRI IAANSITLAK RIAKEIEIIP LQRDDES
//
