ID Q93LM2_NOSP7 Unreviewed; 288 AA.
AC Q93LM2;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=dmtB {ECO:0000313|EMBL:AAK68644.1};
GN OrderedLocusNames=Npun_R1196 {ECO:0000313|EMBL:ACC79921.1};
OS Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=63737 {ECO:0000313|EMBL:AAK68644.1};
RN [1] {ECO:0000313|EMBL:AAK68644.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 29133 {ECO:0000313|EMBL:AAK68644.1};
RA Predki P.F.;
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102 {ECO:0000313|Proteomes:UP000001191};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ACC79921.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 29133 {ECO:0000313|EMBL:ACC79921.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ACC79921.1, ECO:0000313|Proteomes:UP000001191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 {ECO:0000313|EMBL:ACC79921.1}, and ATCC 29133 / PCC
RC 73102 {ECO:0000313|Proteomes:UP000001191};
RX PubMed=23463784; DOI=10.1104/pp.112.213116;
RA Ekman M., Picossi S., Campbell E.L., Meeks J.C., Flores E.;
RT "A Nostoc punctiforme Sugar Transporter Necessary to Establish a
RT Cyanobacterium-Plant Symbiosis.";
RL Plant Physiol. 161:1984-1992(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; AY037294; AAK68644.1; -; Genomic_DNA.
DR EMBL; CP001037; ACC79921.1; -; Genomic_DNA.
DR AlphaFoldDB; Q93LM2; -.
DR STRING; 63737.Npun_R1196; -.
DR REBASE; 18115; M.NpuORF1196P.
DR EnsemblBacteria; ACC79921; ACC79921; Npun_R1196.
DR KEGG; npu:Npun_R1196; -.
DR eggNOG; COG0338; Bacteria.
DR HOGENOM; CLU_063430_6_0_3; -.
DR Proteomes; UP000001191; Chromosome.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.1020.10; Adenine-specific Methyltransferase, Domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR023095; Ade_MeTrfase_dom_2.
DR InterPro; IPR012263; M_m6A_EcoRV.
DR InterPro; IPR012327; MeTrfase_D12.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR30481; DNA ADENINE METHYLASE; 1.
DR PANTHER; PTHR30481:SF2; MODIFICATION METHYLASE; 1.
DR Pfam; PF02086; MethyltransfD12; 1.
DR PIRSF; PIRSF000398; M_m6A_EcoRV; 1.
DR PRINTS; PR00505; D12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AAK68644.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001191};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAK68644.1}.
SQ SEQUENCE 288 AA; 33650 MW; 36E85EB91099C294 CRC64;
MIIKSPLRYP GGKSKAINQI AEYLPDNFSE FREPFVGGGS VFIYLRQKFP HIKIWINDLN
RELFLFWKFA QCDLAHLVQE IRHIKVKYRD GKLLFTELAS VDVNSLSDLE RAVRFFVLNR
ITFSGTVESG GFSQEAFHKR FTNSSIDRLE KLEGILSENV QITNLDYSHL LKSPGENIFL
FLDPPYFSAT KSKLYGKDGD LHTFFEHKRF AELLQQCHHR WLITYDDSSQ IRENFQWANI
SAWELQYGMN NYKQSVAAKG KELFITNYEI KLYLDKKAKN QKLVNPAL
//
