ID Q93TI2_STRAG Unreviewed; 339 AA.
AC Q93TI2;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=N-acetylneuraminate synthase {ECO:0000313|EMBL:OCM72736.1};
DE SubName: Full=Putative N-acetyl neuramic acid synthetase NeuB {ECO:0000313|EMBL:AAK43615.1};
GN Name=neuB {ECO:0000313|EMBL:AAK43615.1};
GN ORFNames=AX245_01515 {ECO:0000313|EMBL:OCM72736.1};
OS Streptococcus agalactiae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1311 {ECO:0000313|EMBL:AAK43615.1};
RN [1] {ECO:0000313|EMBL:AAK43615.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNTC 1/82 {ECO:0000313|EMBL:AAK43615.1};
RX PubMed=12100552; DOI=10.1046/j.1365-2958.2002.02988.x;
RA Chaffin D.O., McKinnon K., Rubens C.E.;
RT "CpsK of Streptococcus agalactiae exhibits alpha2,3-sialyltransferase
RT activity in Haemophilus ducreyi.";
RL Mol. Microbiol. 45:109-122(2002).
RN [2] {ECO:0000313|EMBL:CCG97599.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCH09361 {ECO:0000313|EMBL:CCG97599.1}, and CCH10418
RC {ECO:0000313|EMBL:CCG97681.1};
RX PubMed=23002446; DOI=10.1093/infdis/jis605;
RA Bellais S., Six A., Fouet A., Longo M., Dmytruk N., Glaser P.,
RA Trieu-Cuot P., Poyart C.;
RT "Capsular switching in group B Streptococcus CC17 hypervirulent clone: a
RT future challenge for polysaccharide vaccine development.";
RL J. Infect. Dis. 206:1745-1752(2012).
RN [3] {ECO:0000313|EMBL:CCG97599.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCH09361 {ECO:0000313|EMBL:CCG97599.1}, and CCH10418
RC {ECO:0000313|EMBL:CCG97681.1};
RA TRIEU-CUOT P.;
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OCM72736.1, ECO:0000313|Proteomes:UP000093122}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CZ-PW-140 {ECO:0000313|EMBL:OCM72736.1,
RC ECO:0000313|Proteomes:UP000093122};
RX PubMed=27411639; DOI=10.1038/srep29799;
RA Campisi E., Rinaudo C.D., Donati C., Barucco M., Torricelli G.,
RA Edwards M.S., Baker C.J., Margarit I., Rosini R.;
RT "Serotype IV Streptococcus agalactiae ST-452 has arisen from large genomic
RT recombination events between CC23 and the hypervirulent CC17 lineages.";
RL Sci. Rep. 6:29799-29799(2016).
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DR EMBL; AF355776; AAK43615.1; -; Genomic_DNA.
DR EMBL; HE795400; CCG97599.1; -; Genomic_DNA.
DR EMBL; HE795401; CCG97681.1; -; Genomic_DNA.
DR EMBL; MAWT01000002; OCM72736.1; -; Genomic_DNA.
DR RefSeq; WP_000262515.1; NZ_VSKR01000007.1.
DR AlphaFoldDB; Q93TI2; -.
DR KEGG; sage:EN72_06455; -.
DR KEGG; sagg:EN73_05990; -.
DR PATRIC; fig|1311.132.peg.1119; -.
DR Proteomes; UP000093122; Unassembled WGS sequence.
DR GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR CDD; cd11615; SAF_NeuB_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1210.10; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain; 1.
DR InterPro; IPR006190; AFP_Neu5c_C.
DR InterPro; IPR036732; AFP_Neu5c_C_sf.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR020007; N-AcNeuraminate_synthase.
DR InterPro; IPR013132; Neu5Ac_N.
DR InterPro; IPR013974; SAF.
DR NCBIfam; TIGR03569; NeuB_NnaB; 1.
DR PANTHER; PTHR42966; N-ACETYLNEURAMINATE SYNTHASE; 1.
DR PANTHER; PTHR42966:SF1; SIALIC ACID SYNTHASE; 1.
DR Pfam; PF03102; NeuB; 1.
DR Pfam; PF08666; SAF; 1.
DR SMART; SM00858; SAF; 1.
DR SUPFAM; SSF51269; AFP III-like domain; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50844; AFP_LIKE; 1.
PE 4: Predicted;
FT DOMAIN 279..337
FT /note="AFP-like"
FT /evidence="ECO:0000259|PROSITE:PS50844"
SQ SEQUENCE 339 AA; 37791 MW; 156C2B2BF31457C7 CRC64;
MVYIIAEIGC NHNGDINLAK KMVDVAVSCG VDAVKFQTFK AEKLISKFAP KAEYQKATTG
TADSQLEMTK RLELSFEEYL EMRDYAISKG VETFSTPFDE ESLEFLISTD MPIYKIPSGE
ITNLPYLEKI GKQQKKVILS TGMAVMEEIH QAVNILRQNG TTDISILHCT TEYPTPYPSL
NLNVIHTLKD EFKDLTIGYS DHSIGSEVPI AAAAMGAEVI EKHFTLDTNM EGPDHKASAT
PDILAALVKG VRIVEQALGR FEKIPDPVEE KNKIVARKSV VALKPIKKGD IYSIENITVK
RPGNGISPMN WYDILGQEAQ DDFEEDEVIR DSRFENQLP
//
