ID HM08_CAEEL Reviewed; 276 AA.
AC Q94398;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 3.
DT 27-MAR-2024, entry version 148.
DE RecName: Full=Homeobox protein ceh-8;
GN Name=ceh-8 {ECO:0000312|WormBase:ZK265.4a};
GN ORFNames=ZK265.4 {ECO:0000312|WormBase:ZK265.4a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND MUTAGENESIS OF 49-ARG--CYS-276.
RX PubMed=32814896; DOI=10.1038/s41586-020-2618-9;
RA Reilly M.B., Cros C., Varol E., Yemini E., Hobert O.;
RT "Unique homeobox codes delineate all the neuron classes of C. elegans.";
RL Nature 584:595-601(2020).
CC -!- FUNCTION: Required for cell specification of the RIA interneurons.
CC {ECO:0000269|PubMed:32814896}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR EMBL; BX284601; CAB03519.2; -; Genomic_DNA.
DR PIR; T27812; T27812.
DR RefSeq; NP_492246.2; NM_059845.2.
DR AlphaFoldDB; Q94398; -.
DR SMR; Q94398; -.
DR BioGRID; 56119; 10.
DR IntAct; Q94398; 2.
DR STRING; 6239.ZK265.4a.1; -.
DR EPD; Q94398; -.
DR PaxDb; 6239-ZK265-4; -.
DR EnsemblMetazoa; ZK265.4a.1; ZK265.4a.1; WBGene00000433.
DR GeneID; 191617; -.
DR KEGG; cel:CELE_ZK265.4; -.
DR UCSC; ZK265.4; c. elegans.
DR AGR; WB:WBGene00000433; -.
DR WormBase; ZK265.4a; CE38130; WBGene00000433; ceh-8.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000167708; -.
DR HOGENOM; CLU_963860_0_0_1; -.
DR InParanoid; Q94398; -.
DR OMA; PYPIHFE; -.
DR OrthoDB; 2880524at2759; -.
DR PhylomeDB; Q94398; -.
DR SignaLink; Q94398; -.
DR PRO; PR:Q94398; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000433; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; Q94398; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISS:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007389; P:pattern specification process; TAS:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR24329:SF543; FI01017P-RELATED; 1.
DR PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..276
FT /note="Homeobox protein ceh-8"
FT /id="PRO_0000048984"
FT DNA_BIND 60..119
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 28..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 49..276
FT /note="Missing: In gk116531; RIA interneurons fail to
FT acquire a number of features of RIA identity, including
FT expression of eat-4, glr-3 and dop-2."
FT /evidence="ECO:0000269|PubMed:32814896"
SQ SEQUENCE 276 AA; 31582 MW; 52A435990CEB2D25 CRC64;
MSNPTDNNSA TSSITPNFSA FSSFTTYKPS DSFSSFESDS SPSKSSSSRK NRDKIADKKQ
RRNRTTFTTF QLHALEAAFD KTHYPDVYAR ETLAAKVQLP EVRVQVWFQN RRAKFRRQEK
QDCQGEEKHS LKDTMPSWSW MSENKTDTPP MLPPANTLSS THNNGISDEF FKTSEGKEVY
GFPFAEYGTP ADNTHVSKTG NVFHLNFEDS DKKSMKKESP QTPSTSSPFI SEYHPPFIPY
YIPNQSFSNA FNQYPMPFPY PIHFEPPQLT HSQENC
//
