ID Q95KN3_BOVIN Unreviewed; 183 AA.
AC Q95KN3;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=unspecific monooxygenase {ECO:0000256|ARBA:ARBA00012109};
DE EC=1.14.14.1 {ECO:0000256|ARBA:ARBA00012109};
DE Flags: Fragment;
GN Name=cyp1A1 {ECO:0000313|EMBL:BAB43953.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:BAB43953.1};
RN [1] {ECO:0000313|EMBL:BAB43953.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:BAB43953.1};
RA Guruge K.S., Yamanaka N., Miyazaki S., Kubota T., Motoi Y.;
RT "Identification of CYP1A1 gene expression and ethoxyresorufin-O-deethylase
RT (EROD) activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in primary
RT cultured bovine hepatocytes.";
RL (In) Yang J.H. (eds.);
RL Organohalogen Compounds, vol. 53, pp.251-254, Catholic University of Daegu,
RL Korea, Korea (2001).
RN [2] {ECO:0000313|EMBL:BAB43953.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:BAB43953.1};
RA Yamanaka N., Guruge K.S., Kubota T.;
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004174}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
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DR EMBL; AB060696; BAB43953.1; -; mRNA.
DR AlphaFoldDB; Q95KN3; -.
DR HOGENOM; CLU_001570_22_0_1; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24289:SF18; CYTOCHROME P450 1A2; 1.
DR PANTHER; PTHR24289; STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
PE 2: Evidence at transcript level;
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAB43953.1"
FT NON_TER 183
FT /evidence="ECO:0000313|EMBL:BAB43953.1"
SQ SEQUENCE 183 AA; 20500 MW; 2A36AB7641D40D1F CRC64;
VRTWRPRVPQ GLKSPPEPWG WPLLGHMLML GKNPHVVLSQ LSQRYGDVLQ IRIGCTPVLV
LSGLDTVRQA LVRQGDDFKG RPDLYSFTLI TNGQSMTFNP DSGPVWAARR RLAQNALKSF
STASDPASSS SCYLEEHVNK EAKYLLGKFQ ELMSGPGRFD PYRYIVVSVA NVICAICFGR
RYD
//
