ID Q95M14_HORSE Unreviewed; 317 AA.
AC Q95M14;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Tenomodulin {ECO:0000313|EMBL:BAB69482.2, ECO:0000313|Ensembl:ENSECAP00000016647.1};
GN Name=TNMD {ECO:0000313|EMBL:BAB69482.2,
GN ECO:0000313|Ensembl:ENSECAP00000016647.1,
GN ECO:0000313|VGNC:VGNC:24386};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|EMBL:BAB69482.2};
RN [1] {ECO:0000313|EMBL:BAB69482.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Thoroughbred {ECO:0000313|EMBL:BAB69482.2};
RC TISSUE=Tendon {ECO:0000313|EMBL:BAB69482.2};
RA Hasegawa T.;
RT "Molecular cloning and characrerization of mRNA for equine tenomodulin.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016647.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016647.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [3] {ECO:0000313|Ensembl:ENSECAP00000016647.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016647.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the chondromodulin-1 family.
CC {ECO:0000256|ARBA:ARBA00009898}.
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DR EMBL; AB059407; BAB69482.2; -; mRNA.
DR RefSeq; NP_001075291.1; NM_001081822.1.
DR STRING; 9796.ENSECAP00000016647; -.
DR PaxDb; 9796-ENSECAP00000016647; -.
DR Ensembl; ENSECAT00000020288.2; ENSECAP00000016647.1; ENSECAG00000018944.3.
DR GeneID; 100033840; -.
DR KEGG; ecb:100033840; -.
DR CTD; 64102; -.
DR VGNC; VGNC:24386; TNMD.
DR GeneTree; ENSGT00480000042679; -.
DR HOGENOM; CLU_071852_1_0_1; -.
DR OMA; TIYWIHP; -.
DR OrthoDB; 5342368at2759; -.
DR TreeFam; TF329712; -.
DR Proteomes; UP000002281; Chromosome X.
DR Bgee; ENSECAG00000018944; Expressed in synovial membrane of synovial joint and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0001886; P:endothelial cell morphogenesis; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IBA:GO_Central.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IBA:GO_Central.
DR InterPro; IPR007084; BRICHOS_dom.
DR InterPro; IPR043405; Chondromodulin/Tenomodulin.
DR PANTHER; PTHR14064; CHONDROMODULIN-RELATED; 1.
DR PANTHER; PTHR14064:SF3; TENOMODULIN; 1.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
DR PROSITE; PS50869; BRICHOS; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..186
FT /note="BRICHOS"
FT /evidence="ECO:0000259|PROSITE:PS50869"
SQ SEQUENCE 317 AA; 37165 MW; 0B7CA9D0FE12DA86 CRC64;
MAKNPPENCE DCHILNAEAF KSKKICKSLK ICGLVFGILA LTLIVLFWGG KHFWPETPKK
TYDMEHTFYS NGEKRKIYME IDPVTRTEIF RSGNGTDETL EVHDFKNGYT GIYFVGLQKC
FIKTQIKVIP EFSEPEEEID ENEEITTTFF EQSVIWVPAE KPIENRDFLK NSKILEICDN
VTMYWINPTL IAVSELQDFE EDGEDLHFPT NDKKGIEQNE QWVVPQVKVE KTRRARQASE
EELPINDYTE NGIEFDPMLD ERGYCCIYCR RGNRYCRRVC EPLLGYYPYP YCYQGGRVIC
RVIMPCNWWV ARMLGRV
//
