ID   Q95ZH2_CUPSA            Unreviewed;       626 AA.
AC   Q95ZH2;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Hemocyanin subunit 6'' {ECO:0000313|EMBL:CAC44757.1};
GN   Name=hc-6'' {ECO:0000313|EMBL:CAC44757.1};
OS   Cupiennius salei (American wandering spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Cupiennius.
OX   NCBI_TaxID=6928 {ECO:0000313|EMBL:CAC44757.1};
RN   [1] {ECO:0000313|EMBL:CAC44757.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11842087; DOI=10.1074/jbc.M111368200;
RA   Ballweber P., Markl J., Burmester T.;
RT   "Complete hemocyanin subunit sequences of the hunting spider Cupiennius
RT   salei: recent hemocyanin remodeling in entelegyne spiders.";
RL   J. Biol. Chem. 277:14451-14457(2002).
CC   -!- FUNCTION: Hemocyanins are copper-containing oxygen carriers occurring
CC       freely dissolved in the hemolymph of many mollusks and arthropods.
CC       {ECO:0000256|ARBA:ARBA00002958}.
CC   -!- SUBUNIT: Tarantula hemocyanin is a 24-chain polymer with seven
CC       different chains identified. {ECO:0000256|ARBA:ARBA00011753}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
CC   -!- SIMILARITY: Belongs to the tyrosinase family. Hemocyanin subfamily.
CC       {ECO:0000256|ARBA:ARBA00009470}.
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DR   EMBL; AJ307911; CAC44757.1; -; mRNA.
DR   AlphaFoldDB; Q95ZH2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031404; F:chloride ion binding; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   Gene3D; 2.60.40.1520; Hemocyanin, C-terminal domain; 1.
DR   Gene3D; 1.20.1370.10; Hemocyanin, N-terminal domain; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR013788; Hemocyanin/hexamerin.
DR   InterPro; IPR000896; Hemocyanin/hexamerin_mid_dom.
DR   InterPro; IPR005203; Hemocyanin_C.
DR   InterPro; IPR037020; Hemocyanin_C_sf.
DR   InterPro; IPR005204; Hemocyanin_N.
DR   InterPro; IPR036697; Hemocyanin_N_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11511:SF5; FAT-BODY PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR11511; LARVAL STORAGE PROTEIN/PHENOLOXIDASE; 1.
DR   Pfam; PF03723; Hemocyanin_C; 1.
DR   Pfam; PF00372; Hemocyanin_M; 1.
DR   Pfam; PF03722; Hemocyanin_N; 1.
DR   PRINTS; PR00187; HAEMOCYANIN.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF48050; Hemocyanin, N-terminal domain; 1.
DR   PROSITE; PS00209; HEMOCYANIN_1; 1.
DR   PROSITE; PS00210; HEMOCYANIN_2; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   2: Evidence at transcript level;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxygen transport {ECO:0000256|ARBA:ARBA00022621};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          354..365
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   626 AA;  71708 MW;  31400413B22761B9 CRC64;
     MTIKEKEDRI LPLFENLTSL TRQQLPEDQR DPRLAHAGHL PRGTLFSCFH EKHLEEATEL
     FEILYAANDF DDFVHLASQA RDIVNEGLFV YVLSVAVAHR DDLKGVTLPP IQEVFPDRFV
     PAETINLAIK ESKNHPDQDI EVEIQQTGNI MEPEYKLAYF REDIGVNAHH WYWHVVYPAN
     WNEELTHKVK DRKGELFYYM HQQMCARYDC ERLSNGLNRM IPFHNFKEKL EGYAPHLTSL
     VSGLHYASRP TGFSLRDLPD VDVQDMERWR ERILEAIDLQ HVHAADGTEL ALDEANGANI
     LGTLIEASSS SPNKAFYGSL HNWGHVMMAR MHDPDGRFQE NPGVMSDTST SLRDPIFYRW
     HRFVDNIFQQ YKATLHPYTK EELSFEGIKV LSAQVNAKQP NVVTTYIKDD KLDLSHGINF
     GTGHRVYVKY HHLDHEPFSV IINVENNSGA AKHATLRLFL GPKYDELGNR FVPDDQRRLM
     IELDKFHKEL APGKNVITRN AAESNVTLSH TYTFDELKAG KGGAENATEY CSCGWPEHML
     LPRGTHKGME YELFVMATDY TKDNPDGANV QTICSDAVSY CGAKDQKYPD LKPMGYPFDR
     HLTARNEAEL LTDNMVMTDV VIKFLG
//