ID   Q960B3_DROME            Unreviewed;       592 AA.
AC   Q960B3;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 114.
DE   SubName: Full=SD09786p {ECO:0000313|EMBL:AAK93564.1};
GN   Name=CG15612 {ECO:0000313|EMBL:AAK93564.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAK93564.1};
RN   [1] {ECO:0000313|EMBL:AAK93564.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA   Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M.,
RA   Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.,
RA   Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E.,
RA   Rubin G.M., Celniker S.;
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AY052140; AAK93564.1; -; mRNA.
DR   AlphaFoldDB; Q960B3; -.
DR   UCSC; CG30456-RB; d. melanogaster.
DR   VEuPathDB; VectorBase:FBgn0287631; -.
DR   HOGENOM; CLU_013335_0_0_1; -.
DR   ChiTaRS; CG30456; fly.
DR   ExpressionAtlas; Q960B3; baseline and differential.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:FlyBase.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
DR   GO; GO:0035025; P:positive regulation of Rho protein signal transduction; ISS:FlyBase.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR22826:SF209; DH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          232..414
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          64..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..80
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   592 AA;  69460 MW;  CC5FD772459F2A83 CRC64;
     MHEAESVGGL GTESTPESPM SPQTPDPALL DVRQKVHRFE AFRTNICFIK QERHSLKLLE
     NRRHPSFEDQ SDDHHTPPAT PPRRIRLPGL GSRGSSRSSS IPSFQAGIHE VRSEDEVDQI
     SDFETDSHTA AEEYLVVDTT SEVVPSEEVA DSKVDQQQVQ RSISADQSKE ALTLPLKMRN
     DFPRNYRSTP RRKTEIIGTT NEHLVGKFHS VYQPKDEEEE VVIELRDKSD KCVHPILEEL
     IKTEEAYVNN LFTGIENYGN IFQRKDLPLG LRGKKYDLFG NIEQIAEFHR DEFLPMLQRN
     RRDLKRLFDE FLQFLDQHCF YGYVIFTMNK QKSLKLCDLY KNYFTSIRLE RDDKLGINSF
     LVQPIQRMAR YPLLLTQFIN TFFKNRDIVM KPLIESCCRL EKRLRALLTT TNESEIINDI
     VDCHEFNVYY QGKFRKVNEF QVLDHKLKRS YRSKVFIFDK CIIYTEIKGK NLLFHGRYPC
     EHIGISAKTK SFTLYYERRK QQECEFTADP VQIAIWLDLI RDMINNYANE ERQKLQERYS
     RENDHLHRKA PSFSLYRDSN RFSSDSGIGN IWIMPKADED TISNRTTWYA AT
//