ID   Q96P74_HUMAN            Unreviewed;       110 AA.
AC   Q96P74;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   03-MAY-2023, entry version 80.
DE   SubName: Full=DNAation factor B truncated form I {ECO:0000313|EMBL:AAL02005.1};
GN   Name=DFFB {ECO:0000313|EMBL:AAL02005.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAL02005.1};
RN   [1] {ECO:0000313|EMBL:AAL02005.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15147901; DOI=10.1016/j.febslet.2004.04.050;
RA   Bayascas J.R., Yuste V.J., Sole C., Sanchez-Lopez I., Segura M.F.,
RA   Perera R., Comella J.X.;
RT   "Characterization of splice variants of human caspase-activated DNase with
RT   CIDE-N structure and function.";
RL   FEBS Lett. 566:234-240(2004).
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DR   EMBL; AF409060; AAL02005.1; -; mRNA.
DR   RefSeq; NP_001307061.1; NM_001320132.1.
DR   AlphaFoldDB; Q96P74; -.
DR   PeptideAtlas; Q96P74; -.
DR   DNASU; 1677; -.
DR   GeneID; 1677; -.
DR   CTD; 1677; -.
DR   OrthoDB; 5399497at2759; -.
DR   BioGRID-ORCS; 1677; 22 hits in 1157 CRISPR screens.
DR   ChiTaRS; DFFB; human.
DR   GenomeRNAi; 1677; -.
DR   GO; GO:0004520; F:DNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0006309; P:apoptotic DNA fragmentation; IEA:InterPro.
DR   Gene3D; 3.10.20.10; -; 1.
DR   InterPro; IPR003508; CIDE-N_dom.
DR   InterPro; IPR039729; DFF40.
DR   PANTHER; PTHR13067; CASPASE-ACTIVATED DNASE; 1.
DR   PANTHER; PTHR13067:SF2; CASPASE-ACTIVATED DNASE; 1.
DR   Pfam; PF02017; CIDE-N; 1.
DR   SMART; SM00266; CAD; 1.
DR   SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR   PROSITE; PS51135; CIDE_N; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis {ECO:0000256|PROSITE-ProRule:PRU00447}.
FT   DOMAIN          4..80
FT                   /note="CIDE-N"
FT                   /evidence="ECO:0000259|PROSITE:PS51135"
SQ   SEQUENCE   110 AA;  12106 MW;  34E72888A0F3B909 CRC64;
     MLQKPKSVKL RALRSPRKFG VAGRSCQEVL RKGCLRFQLP ERGSRLCLYE DGTELTEDYF
     PSVPDNAELV LLTLGQAWQG CGRCERHQAL PQCISRATGG AHPGRPAAAV
//