ID Q97CY0_CLOAB Unreviewed; 634 AA.
AC Q97CY0;
DT 01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN Name=lonB {ECO:0000313|EMBL:AAK81636.1};
GN OrderedLocusNames=CA_C3716 {ECO:0000313|EMBL:AAK81636.1};
OS Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS / VKM B-1787).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=272562 {ECO:0000313|EMBL:AAK81636.1, ECO:0000313|Proteomes:UP000000814};
RN [1] {ECO:0000313|EMBL:AAK81636.1, ECO:0000313|Proteomes:UP000000814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787
RC {ECO:0000313|Proteomes:UP000000814};
RX PubMed=11466286; DOI=10.1128/JB.183.16.4823-4838.2001;
RA Nolling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA Doucette-Stamm L., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; AE001437; AAK81636.1; -; Genomic_DNA.
DR PIR; A97356; A97356.
DR RefSeq; NP_350296.1; NC_003030.1.
DR RefSeq; WP_010966976.1; NC_003030.1.
DR AlphaFoldDB; Q97CY0; -.
DR STRING; 272562.CA_C3716; -.
DR MEROPS; S16.005; -.
DR GeneID; 45000212; -.
DR KEGG; cac:CA_C3716; -.
DR PATRIC; fig|272562.8.peg.3905; -.
DR eggNOG; COG1067; Bacteria.
DR HOGENOM; CLU_020014_0_0_9; -.
DR OrthoDB; 2318150at2; -.
DR Proteomes; UP000000814; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR014252; Spore_LonC.
DR NCBIfam; TIGR02903; spore_lon_C; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10046:SF64; LON PROTEASE; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF05362; Lon_C; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000000814};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01122}.
FT DOMAIN 180..363
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000259|PROSITE:PS50045"
FT DOMAIN 460..634
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 544
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 587
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 634 AA; 70693 MW; 21301B8909273E9F CRC64;
MKLQSDSEEI RKEDSKTIPL DVQVNALYDT VKNILDDKTI RARIIKYKLN KYLSSKDSAK
KIYAVNKIIS EGKGIAVIPT NEEETYEAVE DTTNWIVENV AKRYIQNEIE NEVEDALVKR
QNKYLEEVRL GIIRKKKGPE NKSTLKKYDK LKKLEKIKLS KSIQSLLRPQ TFSEIVGQER
AIKALVSKLA SPYPQHIILY GPPGVGKTTA ARIALEEVKK LKYTPFKKDA NFVEVDGATL
RWDPREITNP LLGSVHDPIY QGSKRDLAET GVPEPKSGLV TDAHGGVLFI DEIGELDVML
QNKLLKVLED KKVEFSSSYY DPDDENVPKY IKYFFEKGAP ADFVLIGATT KDPSEINSAL
RSRCTEVYFE PLSSSDIMDI IDNAADKLNV LLEDGVKELI SRYTIQGRRA INILADVYGY
VLYSQGLEPS DKVEIKVKDV ETIVGISRLT PYEKNIFDAE YEVGHVFGLG VSGFMGSTIE
IEAEAFEAKQ KGKGTIRFNE TAGSMAKDSV FNAASVIRKL TDKDIKDYDI HVNVIGGGKI
DGPSAGSAIT ICILSAILNK EVRQDVAMTG EISLRGKIKP VGGVFEKIYG ARRRGIKLVT
VPEDNAKDVP QGLKDIEVKS VTNIEELINI VFKK
//
