ID Q97HL1_CLOAB Unreviewed; 192 AA.
AC Q97HL1;
DT 01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=Indolepyruvate oxidoreductase subunit IorB {ECO:0000256|ARBA:ARBA00017709};
DE EC=1.2.7.8 {ECO:0000256|ARBA:ARBA00012812};
DE AltName: Full=Indolepyruvate ferredoxin oxidoreductase subunit beta {ECO:0000256|ARBA:ARBA00033011};
GN Name=iorB {ECO:0000313|EMBL:AAK79959.1};
GN OrderedLocusNames=CA_C2000 {ECO:0000313|EMBL:AAK79959.1};
OS Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS / VKM B-1787).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=272562 {ECO:0000313|EMBL:AAK79959.1, ECO:0000313|Proteomes:UP000000814};
RN [1] {ECO:0000313|EMBL:AAK79959.1, ECO:0000313|Proteomes:UP000000814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787
RC {ECO:0000313|Proteomes:UP000000814};
RX PubMed=11466286; DOI=10.1128/JB.183.16.4823-4838.2001;
RA Nolling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA Doucette-Stamm L., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
CC -!- FUNCTION: Catalyzes the ferredoxin-dependent oxidative decarboxylation
CC of arylpyruvates. {ECO:0000256|ARBA:ARBA00002995}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] =
CC (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-
CC [ferredoxin]; Xref=Rhea:RHEA:12645, Rhea:RHEA-COMP:10000, Rhea:RHEA-
CC COMP:10001, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17640,
CC ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57271,
CC ChEBI:CHEBI:57287; EC=1.2.7.8;
CC Evidence={ECO:0000256|ARBA:ARBA00033657};
CC -!- SUBUNIT: Heterodimer of the IorA and IorB subunits.
CC {ECO:0000256|ARBA:ARBA00011238}.
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DR EMBL; AE001437; AAK79959.1; -; Genomic_DNA.
DR PIR; D97146; D97146.
DR RefSeq; NP_348619.1; NC_003030.1.
DR RefSeq; WP_010965300.1; NC_003030.1.
DR AlphaFoldDB; Q97HL1; -.
DR STRING; 272562.CA_C2000; -.
DR GeneID; 44998487; -.
DR KEGG; cac:CA_C2000; -.
DR PATRIC; fig|272562.8.peg.2207; -.
DR eggNOG; COG1014; Bacteria.
DR HOGENOM; CLU_087284_1_1_9; -.
DR OrthoDB; 9789125at2; -.
DR Proteomes; UP000000814; Chromosome.
DR GO; GO:0043805; F:indolepyruvate ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR InterPro; IPR017719; Indolepyruvate_Fd_OxRdtase_bsu.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR NCBIfam; TIGR03334; IOR_beta; 1.
DR PANTHER; PTHR43854; INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORB; 1.
DR PANTHER; PTHR43854:SF1; INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORB; 1.
DR Pfam; PF01558; POR; 1.
DR SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000814}.
FT DOMAIN 12..188
FT /note="Pyruvate/ketoisovalerate oxidoreductase catalytic"
FT /evidence="ECO:0000259|Pfam:PF01558"
SQ SEQUENCE 192 AA; 21732 MW; ACEE9B42453ED167 CRC64;
MRNINIIIVG VGGQGALLAS KILGRVGMKK NYDVKVSEVH GMSQRGGSVV TYVRFGEKLH
SPIVEKGQAD IILAFEELEA LRWIEYLNEK GIVIVNTEKI YPLPVIIGKE KYPDNIIDSI
KSVCKNTISL DCLKICKKYK NMKISNMVIL GAFSRVMDIE KELWIQSIKE TVPQRFLDIN
MKAFEEGRME NL
//
