ID Q98143_HHV8 Unreviewed; 580 AA.
AC Q98143; Q2HRB1;
DT 01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT 01-FEB-1997, sequence version 1.
DT 27-MAR-2024, entry version 149.
DE SubName: Full=Core gene UL23 family protein {ECO:0000313|EMBL:ADQ57902.1};
DE SubName: Full=ORF 21 {ECO:0000313|EMBL:AAB62622.1};
DE SubName: Full=ORF21 {ECO:0000313|EMBL:ACY00419.1};
DE SubName: Full=Thymidine kinase {ECO:0000313|EMBL:AAB08396.1};
GN Name=ORF21 {ECO:0000313|EMBL:ADQ57902.1};
OS Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Gammaherpesvirinae; Rhadinovirus;
OC Rhadinovirus humangamma8.
OX NCBI_TaxID=37296 {ECO:0000313|EMBL:AAB08396.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAB08396.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8523568;
RA Moore P.S., Gao S.J., Dominguez G., Cesarman E., Lungu O., Knowles D.M.,
RA Garber R., Pellett P.E., McGeoch D.J., Chang Y.;
RT "Primary characterization of a herpesvirus agent associated with Kaposi's
RT sarcomae.";
RL J. Virol. 70:549-558(1996).
RN [2] {ECO:0000313|EMBL:AAB62622.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9151804;
RA Neipel F., Albrecht J.C., Fleckenstein B.;
RT "Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus
RT human herpesvirus 8: determinants of its pathogenicity?";
RL J. Virol. 71:4187-4192(1997).
RN [3] {ECO:0000313|EMBL:AAB62622.1}
RP NUCLEOTIDE SEQUENCE.
RA Neipel F., Albrecht J.-C., Ensser A., Huang Y.-Q., Li J.J.,
RA Friedman-Kien A.E., Fleckenstein B.;
RT "The genome of human herpesvirus 8 cloned from Kaposi's sarcoma.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ACY00419.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JSC-1 {ECO:0000313|EMBL:ACY00419.1};
RA Brulois K., Lee A., Chang H.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:ADQ57902.1, ECO:0000313|Proteomes:UP000146550}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSHV-BAC36 {ECO:0000313|EMBL:ADQ57902.1};
RX PubMed=21307197; DOI=10.1128/JVI.02068-10;
RA Yakushko Y., Hackmann C., Gunther T., Ruckert J., Henke M., Koste L.,
RA Alkharsah K., Bohne J., Grundhoff A., Schulz T.F., Henke-Gendo C.;
RT "Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome
RT contains a duplication of a long unique-region fragment within the terminal
RT repeat region.";
RL J. Virol. 85:4612-4617(2011).
RN [6] {ECO:0000313|EMBL:ACY00419.1, ECO:0000313|Proteomes:UP000141755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JSC-1 {ECO:0000313|EMBL:ACY00419.1};
RX PubMed=22740391; DOI=10.1128/JVI.01019-12;
RA Brulois K.F., Chang H., Lee A.S., Ensser A., Wong L.Y., Toth Z., Lee S.H.,
RA Lee H.R., Myoung J., Ganem D., Oh T.K., Kim J.F., Gao S.J., Jung J.U.;
RT "Construction and Manipulation of a New Kaposi's Sarcoma-Associated
RT Herpesvirus Bacterial Artificial Chromosome Clone.";
RL J. Virol. 86:9708-9720(2012).
RN [7] {ECO:0000313|EMBL:AFQ99151.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KSHV-BAC36-deltaK15 {ECO:0000313|EMBL:AFQ99151.1};
RX PubMed=23028325; DOI=10.1371/journal.ppat.1002927;
RA Bala K., Bosco R., Gramolelli S., Haas D.A., Kati S., Pietrek M.,
RA Havemeier A., Yakushko Y., Singh V.V., Dittrich-Breiholz O., Kracht M.,
RA Schulz T.F.;
RT "Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced
RT angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1
RT expression.";
RL PLoS Pathog. 8:E1002927-E1002927(2012).
RN [8] {ECO:0000313|EMBL:AFU08288.1, ECO:0000313|Proteomes:UP000097197}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG1 {ECO:0000313|EMBL:AFU08288.1};
RX PubMed=22925337; DOI=10.1016/j.virol.2012.08.014;
RA Tamburro K.M., Yang D., Poisson J., Fedoriw Y., Roy D., Lucas A., Sin S.H.,
RA Malouf N., Moylan V., Damania B., Moll S., van der Horst C., Dittmer D.P.;
RT "Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine
RT syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and
RT human herpesvirus 6A.";
RL Virology 433:220-225(2012).
RN [9] {ECO:0000313|EMBL:AKE33057.1, ECO:0000313|Proteomes:UP000155579}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=25736227; DOI=10.1016/j.jviromet.2015.02.022;
RA Kati S., Hage E., Mynarek M., Ganzenmueller T., Indenbirken D.,
RA Grundhoff A., Schulz T.F.;
RT "Generation of high-titre virus stocks using BrK.219, a B-cell line
RT infected stably with recombinant Kaposi's sarcoma-associated herpesvirus.";
RL J. Virol. Methods 217:79-86(2015).
RN [10] {ECO:0000313|EMBL:QKE51342.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P044_PEL {ECO:0000313|EMBL:QKE51342.1}, P100_PEL
RC {ECO:0000313|EMBL:QKE51690.1}, and P133_MCD
RC {ECO:0000313|EMBL:QKE51777.1};
RA Jary A., Leducq V., Desire N., Palich R., Joly V., Canestri A.,
RA Gothland A., Lambert-Niclot S., Surgers L., Amiel C., Descamps D.,
RA Spano J.-P., Katlama C., Calvez V., Marcelin A.-G.;
RT "Spread of a new Kaposi's sarcoma-associated herpesvirus variant driving
RT severe pathologies in men who have sex with men.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:QLF96513.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FNL002 {ECO:0000313|EMBL:QLF96513.1}, FNL003
RC {ECO:0000313|EMBL:QLF96597.1}, FNL004 {ECO:0000313|EMBL:QLF96681.1},
RC FNL005 {ECO:0000313|EMBL:QLF96765.1}, FNL006
RC {ECO:0000313|EMBL:QLF96849.1}, FNL007 {ECO:0000313|EMBL:QLF96934.1},
RC FNL009 {ECO:0000313|EMBL:QLF97019.1}, and FNL011
RC {ECO:0000313|EMBL:QLF97104.1};
RA Cornejo Castro E.M., Marshall V., Lack J., Lurain K., Immonen T., Labo N.,
RA Fisher N.C., Ramaswami R., Wyvill K.M., Aleman K., Polizzotto M.N., Cam M.,
RA Keele B.F., Yarchoan R., Uldrick T.S., Whitby D.;
RT "Dual infection and recombination of Kaposi sarcoma herpesvirus revealed by
RT whole-genome sequence analysis of effusion samples.";
RL Virus Evol. 0:0-0(2020).
RN [12] {ECO:0000313|EMBL:QQL05608.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCBL1 {ECO:0000313|EMBL:QQL05608.1};
RA Santiago J.C.A.;
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:QQL05608.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCBL1 {ECO:0000313|EMBL:QQL05608.1};
RA Goldman J.D., Zhao H., Pankow A.P., Okuku F., Schmitt M.W., Chen L.H.,
RA Hill C.A., Casper C., Phipps W.T., Mullins J.I.;
RT "Tumor-specific changes in Kaposi sarcoma-associated herpesvirus genomes in
RT Ugandan adults with Kaposi sarcoma.";
RL Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q98143; Q77UV9: KIE-2; NbExp=2; IntAct=EBI-2608563, EBI-2608731;
CC Q98143; Q76RG4: ORF53; NbExp=2; IntAct=EBI-2608563, EBI-2608592;
CC Q98143; Q76RF6: ORF62; NbExp=2; IntAct=EBI-2608563, EBI-2608615;
CC Q98143; O40942; NbExp=4; IntAct=EBI-2608563, EBI-2608626;
CC Q98143; Q9Y5X1: SNX9; Xeno; NbExp=2; IntAct=EBI-2608563, EBI-77848;
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DR EMBL; U40377; AAB08396.1; -; Genomic_DNA.
DR EMBL; U93872; AAB62622.1; -; Genomic_DNA.
DR EMBL; GQ994935; ACY00419.1; -; Genomic_DNA.
DR EMBL; HQ404500; ADQ57902.1; -; Genomic_DNA.
DR EMBL; JX228174; AFQ99151.1; -; Genomic_DNA.
DR EMBL; JQ619843; AFU08288.1; -; Genomic_DNA.
DR EMBL; KF588566; AKE33057.1; -; Genomic_DNA.
DR EMBL; MK876733; QKE51342.1; -; Genomic_DNA.
DR EMBL; MK876737; QKE51690.1; -; Genomic_DNA.
DR EMBL; MK876738; QKE51777.1; -; Genomic_DNA.
DR EMBL; MN419219; QLF96513.1; -; Genomic_DNA.
DR EMBL; MN419220; QLF96597.1; -; Genomic_DNA.
DR EMBL; MN419221; QLF96681.1; -; Genomic_DNA.
DR EMBL; MN419222; QLF96765.1; -; Genomic_DNA.
DR EMBL; MN419223; QLF96849.1; -; Genomic_DNA.
DR EMBL; MN419224; QLF96934.1; -; Genomic_DNA.
DR EMBL; MN419225; QLF97019.1; -; Genomic_DNA.
DR EMBL; MN419226; QLF97104.1; -; Genomic_DNA.
DR EMBL; MT936340; QQL05608.1; -; Genomic_DNA.
DR RefSeq; YP_001129374.1; NC_009333.1.
DR IntAct; Q98143; 50.
DR DNASU; 4961484; -.
DR GeneID; 4961484; -.
DR KEGG; vg:4961484; -.
DR OrthoDB; 7738at10239; -.
DR Proteomes; UP000097197; Genome.
DR Proteomes; UP000141755; Genome.
DR Proteomes; UP000146550; Genome.
DR Proteomes; UP000155579; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006230; P:TMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04029; HSV_KITH; 1.
DR InterPro; IPR001889; Herpes_TK.
DR InterPro; IPR013672; Herpes_TK_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00693; Herpes_TK; 1.
DR Pfam; PF08465; Herpes_TK_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAB08396.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAB08396.1}.
FT DOMAIN 532..564
FT /note="Herpesvirus thymidine kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08465"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..149
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 64537 MW; C34E41D6B181DAFB CRC64;
MAEGGFGADS VGRGGEKASV TRGGRWDLGS SDDESSTSTT STDMDDLPEE RKPLTGKSVK
TSYIYDVPTV PTSKPWHLMH DNSLYATPRF PPRPLIRHPS EKGSIFASRL SATDDDSGDY
APMDRFAFQS PRVCGRPPLP PPNHPPPATR PADASMGDVG WADLQGLKRT PKGFLKTSTK
GGSLKARGRD VGDRLRDGGF AFSPRGVKSA IGQNIKSWLG IGESSATAVP VTTQLMVPVH
LIRTPVTVDY RNVYLLYLEG VMGVGKSTLV NAVCGILPQE RVTSFPEPMV YWTRAFTDCY
KEISHLMKSG KAGDPLTSAK IYSCQNKFSL PFRTNATAIL RMMQPWNVGG GSGRGTHWCV
FDRHLLSPAV VFPLMHLKHG RLSFDHFFQL LSIFRATEGD VVAILTLSSA ESLRRVRARG
RKNDGTVEQN YIRELAWAYH AVYCSWIMLQ YITVEQMVQL CVQTTNIPEI CFRSVRLAHK
EETLKNLHEQ SMLPMITGVL DPVRHHPVVI ELCFCFFTEL RKLQFIVADA DKFHDDVCGL
WTEIYRQILS NPAIKPRAIN WPALESQSKA VNHLEETCRV
//
