ID Q99QN4_STRCO Unreviewed; 296 AA.
AC Q99QN4;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=Aminoglycoside phosphotransferase domain-containing protein {ECO:0000259|Pfam:PF01636};
GN OrderedLocusNames=SCP1.305 {ECO:0000313|EMBL:CAC36830.1}, SCP1.49c
GN {ECO:0000313|EMBL:CAC36571.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OG Plasmid SCP1 {ECO:0000313|Proteomes:UP000001973}.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAC36830.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAC36830.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A3 {ECO:0000313|EMBL:CAC36830.1};
RC PLASMID=SCP1 {ECO:0000313|Proteomes:UP000001973};
RX PubMed=9573173;
RA Redenbach M., Ikeda K., Yamasaki M., Kinashi H.;
RT "Cloning and physical mapping of the EcoRI fragments of the giant linear
RT plasmid SCP1.";
RL J. Bacteriol. 180:2796-2799(1998).
RN [2] {ECO:0000313|EMBL:CAC36830.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A3 {ECO:0000313|EMBL:CAC36830.1};
RC PLASMID=SCP1 {ECO:0000313|Proteomes:UP000001973};
RA Bentley S.D., Parkhill J., Barrell B.G., Rajandream M.A.;
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RC PLASMID=SCP1 {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
RN [4] {ECO:0000313|EMBL:CAC36830.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A3 {ECO:0000313|EMBL:CAC36830.1};
RC PLASMID=SCP1 {ECO:0000313|Proteomes:UP000001973};
RX PubMed=18988741; DOI=10.1073/pnas.0805530105;
RA Corre C., Song L., O'Rourke S., Chater K.F., Challis G.L.;
RT "2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production
RT inducers discovered by Streptomyces coelicolor genome mining.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:17510-17515(2008).
RN [5] {ECO:0000313|EMBL:CAC36830.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A3 {ECO:0000313|EMBL:CAC36830.1};
RC PLASMID=SCP1 {ECO:0000313|Proteomes:UP000001973};
RX PubMed=19054329; DOI=10.1111/j.1365-2958.2008.06560.x;
RA O'Rourke S., Wietzorrek A., Fowler K., Corre C., Challis G.L., Chater K.F.;
RT "Extracellular signalling, translational control, two repressors and an
RT activator all contribute to the regulation of methylenomycin production in
RT Streptomyces coelicolor.";
RL Mol. Microbiol. 71:763-778(2009).
RN [6] {ECO:0000313|EMBL:CAC36830.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A3 {ECO:0000313|EMBL:CAC36830.1};
RC PLASMID=SCP1 {ECO:0000313|Proteomes:UP000001973};
RA Brown S.P., Murphy L.D., Harris D.;
RT ".";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AL589148; CAC36571.1; -; Genomic_DNA.
DR EMBL; AL589148; CAC36830.1; -; Genomic_DNA.
DR RefSeq; NP_639624.1; NC_003903.1.
DR RefSeq; NP_639914.1; NC_003903.1.
DR AlphaFoldDB; Q99QN4; -.
DR STRING; 100226.gene:17765555; -.
DR PATRIC; fig|100226.15.peg.7997; -.
DR HOGENOM; CLU_029616_0_0_11; -.
DR InParanoid; Q99QN4; -.
DR OrthoDB; 21342at2; -.
DR Proteomes; UP000001973; Plasmid SCP1.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT DOMAIN 34..252
FT /note="Aminoglycoside phosphotransferase"
FT /evidence="ECO:0000259|Pfam:PF01636"
SQ SEQUENCE 296 AA; 33124 MW; 12C6491F9E656436 CRC64;
MNHPAPIPND LWAWALDHLP DARTATDVSW ARGDSRVWRI DTTTASAFVK ISPSVRDYTR
ETDAYVYAAR ALAPHQAPRL IASDHHLLAL LTTPQPGKIV RGLPLEEDQE LRVHEEAGRL
LRRWHDHSAP ATADEQTAIR DAITGQTDEA AACLQATRHR LAPDEQKLVE EVAHDLPHLA
DELPLVYRHG DYATRNWLWD PAQHGFGVID FAMAAPGIAV EEYVWLHSAL WTPRPSLRDA
FFTGYGRTLA AVERQALTLF AARLGVSYLH AGLTKQDPVL TERGHLVLHR MTADQN
//
