ID Q9BF41_PANON Unreviewed; 325 AA.
AC Q9BF41;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Sphingosine 1-phosphate receptor 1 {ECO:0000256|ARBA:ARBA00017480};
DE AltName: Full=Sphingosine 1-phosphate receptor Edg-1 {ECO:0000256|ARBA:ARBA00033312};
DE Flags: Fragment;
GN Name=EDG1 {ECO:0000313|EMBL:AAK02008.1};
OS Panthera onca (Jaguar) (Felis onca).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae;
OC Panthera.
OX NCBI_TaxID=9690 {ECO:0000313|EMBL:AAK02008.1};
RN [1] {ECO:0000313|EMBL:AAK02008.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11214319; DOI=10.1038/35054550;
RA Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A.,
RA O'Brien S.J.;
RT "Molecular phylogenetics and the origins of placental mammals.";
RL Nature 409:614-618(2001).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AY011740; AAK02008.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9BF41; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0038036; F:sphingosine-1-phosphate receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR CDD; cd15346; 7tmA_S1PR1_Edg1; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000987; EDG1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004061; S1P_rcpt.
DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22750:SF16; SPHINGOSINE 1-PHOSPHATE RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00642; EDG1RECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01523; S1PRECEPTOR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR604061-50};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 39..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..270
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DISULFID 143..150
FT /evidence="ECO:0000256|PIRSR:PIRSR604061-50"
FT DISULFID 241..246
FT /evidence="ECO:0000256|PIRSR:PIRSR604061-50"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAK02008.1"
FT NON_TER 325
FT /evidence="ECO:0000313|EMBL:AAK02008.1"
SQ SEQUENCE 325 AA; 36558 MW; C1345A96E90BDA2F CRC64;
ENGIKLSSVV FILICCFIIL ENIFVLLTIW KTKKFHRPMY YFIGNLALSD LLAGVAYTAN
LLLSGATTYK LTPAQWFLRE GSMFVALSAS VFSLLAIAIE RYITMLKMKL HNGSNSFRSF
LLISACWVIS LILGGFPIMG WNCINMLASC STVLPLYHKH YILFCTTVFT LLLLAIVILY
CRIYSLVRTR SRRLTFRKNI SKASRSSEKS LALLKTVIIV LSVFIACWAP LFILLLLDVG
CKVKTCDILF RAEYFLVLAV LNSGTNPIIY TLTNKEMRRA FIRILSCCKC PSGDSAGKFK
RPIIAGMEFS RSKSDNSSHP QKDDG
//
