ID Q9BFH9_OKAJO Unreviewed; 189 AA.
AC Q9BFH9;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 22-FEB-2023, entry version 59.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AAG47525.1};
OS Okapia johnstoni (Okapi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Giraffidae;
OC Okapia.
OX NCBI_TaxID=86973 {ECO:0000313|EMBL:AAG47525.1};
RN [1] {ECO:0000313|EMBL:AAG47525.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11214319; DOI=10.1038/35054550;
RA Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A.,
RA O'Brien S.J.;
RT "Molecular phylogenetics and the origins of placental mammals.";
RL Nature 409:614-618(2001).
CC -!- FUNCTION: During development, promotes the survival and differentiation
CC of selected neuronal populations of the peripheral and central nervous
CC systems. Participates in axonal growth, pathfinding and in the
CC modulation of dendritic growth and morphology. Major regulator of
CC synaptic transmission and plasticity at adult synapses in many regions
CC of the CNS. {ECO:0000256|RuleBase:RU364086}.
CC -!- FUNCTION: Important signaling molecule that activates signaling
CC cascades downstream of NTRK2 (By similarity). During development,
CC promotes the survival and differentiation of selected neuronal
CC populations of the peripheral and central nervous systems. Participates
CC in axonal growth, pathfinding and in the modulation of dendritic growth
CC and morphology. Major regulator of synaptic transmission and plasticity
CC at adult synapses in many regions of the CNS. The versatility of BDNF
CC is emphasized by its contribution to a range of adaptive neuronal
CC responses including long-term potentiation (LTP), long-term depression
CC (LTD), certain forms of short-term synaptic plasticity, as well as
CC homeostatic regulation of intrinsic neuronal excitability.
CC {ECO:0000256|ARBA:ARBA00025383}.
CC -!- SUBUNIT: Monomers and homodimers (By similarity). Binds to NTRK2/TRKB.
CC Can form heterodimers with other neurotrophin family members, such as
CC NTF3 and NTF4 (in vitro), but the physiological relevance of this is
CC not clear (By similarity). BDNF precursor form: interacts with the
CC heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower
CC affinity for the heterodimer formed by NGFR and SORCS2.
CC {ECO:0000256|ARBA:ARBA00025882}.
CC -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
CC {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; AY011492; AAG47525.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9BFH9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 125..189
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAG47525.1"
FT NON_TER 189
FT /evidence="ECO:0000313|EMBL:AAG47525.1"
SQ SEQUENCE 189 AA; 21026 MW; 6FBE047DC8B24F8C CRC64;
YFGCMKVAPM KEANLRAQGS LAYPGVRTHG TLESMNGPKV GSRGLTSSSS LADTFEHVIE
ELLDEDQKVR PSEENNKDAD MYTSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR
HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP
MGYTKEGCR
//
