ID   Q9BFJ1_NOMCO            Unreviewed;       186 AA.
AC   Q9BFJ1;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:AAG47512.1};
OS   Nomascus concolor (Black crested gibbon) (Hylobates concolor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=29089 {ECO:0000313|EMBL:AAG47512.1};
RN   [1] {ECO:0000313|EMBL:AAG47512.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11214319; DOI=10.1038/35054550;
RA   Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.P., Ryder O.A.,
RA   O'Brien S.J.;
RT   "Molecular phylogenetics and the origins of placental mammals.";
RL   Nature 409:614-618(2001).
CC   -!- FUNCTION: During development, promotes the survival and differentiation
CC       of selected neuronal populations of the peripheral and central nervous
CC       systems. Participates in axonal growth, pathfinding and in the
CC       modulation of dendritic growth and morphology. Major regulator of
CC       synaptic transmission and plasticity at adult synapses in many regions
CC       of the CNS. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
CC       {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; AY011479; AAG47512.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9BFJ1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU364086};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          122..186
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAG47512.1"
FT   NON_TER         186
FT                   /evidence="ECO:0000313|EMBL:AAG47512.1"
SQ   SEQUENCE   186 AA;  20627 MW;  C3D8E1CE3CCF3051 CRC64;
     YFGCMKAAPM KEANVRGQGG LAYPGVRTHG TLESVNGPKA GSRGLTSLAD TFEHVIEELL
     DEDQKVRPNE ENNKDADLYT SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN MSMRVRRHSD
     PARRGELSVC DSISEWVTAA DKKTAVDMSG GTVTVLEKVP VSKGQLKQYF YETKCNPMGY
     TKEGCR
//