ID Q9BIB7_CAEEL Unreviewed; 549 AA.
AC Q9BIB7;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 150.
DE SubName: Full=RRM domain-containing protein {ECO:0000313|EMBL:CCD68995.1};
GN Name=hrpf-1 {ECO:0000313|EMBL:CCD68995.1,
GN ECO:0000313|WormBase:W02D3.11a};
GN ORFNames=CELE_W02D3.11 {ECO:0000313|EMBL:CCD68995.1}, W02D3.11
GN {ECO:0000313|WormBase:W02D3.11a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD68995.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD68995.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68995.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284601; CCD68995.1; -; Genomic_DNA.
DR RefSeq; NP_740877.1; NM_170888.4.
DR AlphaFoldDB; Q9BIB7; -.
DR SMR; Q9BIB7; -.
DR DIP; DIP-24897N; -.
DR IntAct; Q9BIB7; 3.
DR STRING; 6239.W02D3.11a.1; -.
DR EPD; Q9BIB7; -.
DR PaxDb; 6239-W02D3-11a; -.
DR PeptideAtlas; Q9BIB7; -.
DR EnsemblMetazoa; W02D3.11a.1; W02D3.11a.1; WBGene00020936.
DR GeneID; 172395; -.
DR KEGG; cel:CELE_W02D3.11; -.
DR UCSC; W02D3.11b; c. elegans.
DR AGR; WB:WBGene00020936; -.
DR WormBase; W02D3.11a; CE26020; WBGene00020936; hrpf-1.
DR eggNOG; KOG4211; Eukaryota.
DR HOGENOM; CLU_479166_0_0_1; -.
DR InParanoid; Q9BIB7; -.
DR OMA; QCRGLPW; -.
DR OrthoDB; 2967733at2759; -.
DR PhylomeDB; Q9BIB7; -.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72203; Processing of Capped Intron-Containing Pre-mRNA.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00020936; Expressed in embryo and 4 other cell types or tissues.
DR ExpressionAtlas; Q9BIB7; baseline and differential.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
DR CDD; cd12254; RRM_hnRNPH_ESRPs_RBM12_like; 3.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR13976; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED; 1.
DR PANTHER; PTHR13976:SF84; HNRNP F HOMOLOG; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q9BIB7,
KW ECO:0007829|PeptideAtlas:Q9BIB7};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 5..79
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 123..200
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 74..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 61774 MW; F8C3202C339CB7F2 CRC64;
MSTAYEVQCR GLPWEATEQE LRDFFGNNGI ESLEIPRRNG RTSGDAKVVF TNEEDYNNAL
KKDREHLGSR YIEVFPAGGA PTRRGDRGER GDRGDRDHYR SRGAPPRDRY SDRGGPRSSG
PDSIVRLRGL PFSVTSRDIS DFLAPLPIVR DGILLPDQQR ARPGGEAYVC FETMESVQIA
KQRHMKNIGH RYIEVFEATH RDLSRFAEEN DLRVPRFGPP PFASAPQTAP RGAYDPYSQP
TDPYRNATDY RRAAEPEDPY ARSRAPSVQD YGVRASYDPY TQPAAPVSSY PSQQQPSAGY
YDNYAPKTAY ESYGRERGPD PRDVRDPRDS RMPDPRDSRA LSDPYAAESR YSEYGYESRE
PYWRGGSGGP PSIGGGVGGG GAPLAPTGRD PYSVGESWAN GAGGPGGPPP VSSDRDRYGS
GGYASEPYAQ REAGGAMRRS EYGRPDDRYS KPEPYGYSRD RDYGAPQNQH FVLRMRGVPF
RASEADVYDF FHPIRPNQVE LLRDHQFQRP SGDARVIFYN RKDYDDALMK DKQYMGERYI
EMIPDNGRY
//
