ID Q9C2K9_NEUCS Unreviewed; 548 AA.
AC Q9C2K9;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=3H10.030 {ECO:0000313|EMBL:CAC28642.1};
GN ORFNames=GE21DRAFT_7666 {ECO:0000313|EMBL:KHE87811.1};
OS Neurospora crassa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=5141 {ECO:0000313|EMBL:CAC28642.1};
RN [1] {ECO:0000313|EMBL:CAC28642.1}
RP NUCLEOTIDE SEQUENCE.
RA Schulte U., Aign V., Hoheisel J., Brandt P., Fartmann B., Holland R.,
RA Nyakatura G., Mewes H.W., Mannhaupt G.;
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAC28642.1}
RP NUCLEOTIDE SEQUENCE.
RA German Neurospora genome project;
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KHE87811.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=73 {ECO:0000313|EMBL:KHE87811.1};
RG DOE Joint Genome Institute;
RA Baker S.E., Grigoriev I., Haridas S., LaButti K., McCluskey K.;
RT "Draft genome sequence of Neurospora crassa strain FGSC 73.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0007829|PDB:4RXH}
RP X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 75-548.
RX PubMed=26091498; DOI=10.1371/journal.pone.0128687;
RA Bernardes N.E., Takeda A.A., Dreyer T.R., Freitas F.Z., Bertolini M.C.,
RA Fontes M.R.;
RT "Structure of Importin-alpha from a Filamentous Fungus in Complex with a
RT Classical Nuclear Localization Signal.";
RL PLoS ONE 10:e0128687-e0128687(2015).
RN [5] {ECO:0007829|PDB:5VQI}
RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 75-548.
RX PubMed=29054975; DOI=10.1042/BCJ20170654;
RA Bernardes N.E., Takeda A.A.S., Dreyer T.R., Cupertino F.B., Virgilio S.,
RA Pante N., Bertolini M.C., Fontes M.R.M.;
RT "Nuclear transport of the <i>Neurospora crassa</i> NIT-2 transcription
RT factor is mediated by importin-alpha.";
RL Biochem. J. 474:4091-4104(2017).
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL513442; CAC28642.1; -; Genomic_DNA.
DR EMBL; KN389640; KHE87811.1; -; Genomic_DNA.
DR PDB; 4RXH; X-ray; 1.76 A; B=75-548.
DR PDB; 5VQI; X-ray; 2.50 A; B=75-548.
DR PDBsum; 4RXH; -.
DR PDBsum; 5VQI; -.
DR SMR; Q9C2K9; -.
DR VEuPathDB; FungiDB:NCU01249; -.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_018084_6_0_1; -.
DR OMA; EMIQMLY; -.
DR OrthoDB; 916229at2759; -.
DR Proteomes; UP000053122; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4RXH, ECO:0007829|PDB:5VQI};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..58
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 124..166
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 166..208
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 335..367
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 59697 MW; 77EB61AA5273D504 CRC64;
MADRYIPEHR RTQFKAKSAF KPDELRRRRE EQQVEIRKAK REENLAKRRG IGAGDSRPGA
SLGAAPDSDD ENPPTESQLS EDLPKMVEGV FSSEIDKQIQ ATTKFRKLLS KERNPPIEEV
IKTGVVGRFV EFLRSPHTLV QFEAAWALTN IASGSATQTQ VVIEAGAVPI FVELLGSPEP
DVREQAVWAL GNIAGDSPQC RDYVLSCGAL RPLLTLLGDS RKLSMLRNAT WTLSNFCRGK
TPQPDWNTIA PALPVLAKLV YSLDDEVLID ACWAISYLSD GSNDKIQAVI EAGIPRRLVE
LLMHASTSVQ TPALRSVGNI VTGDDVQTQV IINCGALPCL LSLLSSNKDG IRKEACWTIS
NITAGNSAQI QSVIDANIIP PLIHLLSHAD LKTRKEACWA ISNATSGGLQ KPDQIRYLVA
QGCIKPLCDL LACPDNKIIQ VALDGLENIL KVGELDKNAA GDGPDSINRY ALFIEECGGM
EKIHDCQTNA NEEIYMKAYN IIEKYFSDED EAGDEAMGAQ QQFGFGASGG AQQGGFNFGA
NGTESMDM
//
